Reviewed, UniProtKB/Swiss-Prot Q1RK25 (EX7L_RICBR)

Names and origin

Protein names

Recommended name:
    Exodeoxyribonuclease 7 large subunit
    EC=3.1.11.6
Alternative name(s):
    Exodeoxyribonuclease VII large subunit
      Short name=Exonuclease VII large subunit

Gene names

Name:	xseA
Ordered Locus Names:	RBE_0208

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity.
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP MF_00378
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xseA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Exodeoxyribonuclease 7 large subunit HAMAP MF_00378		PRO_0000273121

Sequences

	Sequence		Length	Mass (Da)
	Q1RK25-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 0B31507C46A20525	FASTA	442	49,474
	10 20 30 40 50 60 MLDNFTSSQT TKEFSVSEIS NKIKELLENN FGYIKVKGEI SGLKIASSGH AYFNLKENTA 70 80 90 100 110 120 ILACTCWRPI LAKIKFPLND GMEVVISGKL SSYAGNSRYQ LSVENLQPAG LGAMVQILNE 130 140 150 160 170 180 RKARLEKEGL FNKIRKPIPF LPNKIGVITS ITGAVIQDII HRIRERFPTH VIIWPVSVQG 190 200 210 220 230 240 ENSGNEIAEA IDGFNKLEEA NKPDVIIVAR GGGSIEDLWS FNDEVLVRAT YNSKIPIISA 250 260 270 280 290 300 VGHEVDYTLI DLAADKRAPT PTAAAEFAVP VRSILNSTLQ SYEKVLVTNT KQLVKNHEQA 310 320 330 340 350 360 ITNYDKINRY LAHYINHKQQ LLDETGFNLL DSLPCLISLK ETKLKSFSKE RIHPHKIITY 370 380 390 400 410 420 KTLELTHKAA YIIKSANNTL KNFEYKLELN SLLLLSLDYH NVLKRGFAIV KGESGNFVSS 430 440 KTTTEKVLNI QFFDGNIKAV RD

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04289.1.
RefSeq	YP_537378.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK25.
Genome annotation databases
GeneID	3995972.
GenomeReviews	Gene locus RBE_0208 in contig CP000087_GR.
KEGG	rbe:RBE_0208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RK25.
OMA	FNDEILV
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0208-MON.
Family and domain databases
HAMAP	MF_00378. [Tree]
InterPro	IPR003753. Exonuc_VII_L. IPR020579. Exonuc_VII_lsu_C. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7L_RICBR

Accession

Primary (citable) accession number: Q1RK25

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)