Reviewed, UniProtKB/Swiss-Prot Q1RK03 (PARE_RICBR)

Names and origin

Protein names

Recommended name:
    DNA topoisomerase 4 subunit B
    EC=5.99.1.-
Alternative name(s):
    Topoisomerase IV subunit B

Gene names

Name:	parE
Ordered Locus Names:	RBE_0230

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Topoisomerase IV is essential for chromosome segregation. It has relaxation of supercoiled DNA activity. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.
Subunit structure	Composed of two subunits: parC and parE By similarity.
Sequence similarities	Belongs to the type II topoisomerase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Isomerase Topoisomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 662	662	DNA topoisomerase 4 subunit B		PRO_0000273116

Sequences

	Sequence		Length	Mass (Da)
	Q1RK03-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: E9AEDFDFC7D328CF	FASTA	662	73,986
	10 20 30 40 50 60 MSDLFSFNKE KKTKIINNTY SAKDIEVLEG LEPVRKRPGM YIGGTDLNAM HHLVSEVLDN 70 80 90 100 110 120 SMDEAVAGFA SIITIKMHQD HSITISDNGR GIPIDNHPKF PNKSALEVIL TTLHSGGKFS 130 140 150 160 170 180 SNVYQTAGGL HGVGVSVVNA LAEHLEIKVY KQGKLYKQSY AKGEKLTELI CEEAPKRLKG 190 200 210 220 230 240 TSINFIPDPE IFGDKIHFNP KKVYELARSK AYLYRGVTIE WECEIEASSD VPKKALINFP 250 260 270 280 290 300 NGLKDYLSSK ITPDDLITTE IFSGNVESEQ DGIKLEWAIC WQNNDSSAFI QSYCNTVPTP 310 320 330 340 350 360 LGGTHEQGLK SALLRGLKAY GEMVGNKKTA NLAIEDILET ASVVLSIFIA EPTFQGQTKE 370 380 390 400 410 420 KLVSQGVSKP AENIIKDHFD HFLSSNKTIA NNLLEHFIAI AEFRLNKKNE KTISRKNATQ 430 440 450 460 470 480 KLRLPGKLAD CTRTSPEGTE LFIVEGDSAG GSAKQARNRE TQAVLPLWGK VLNVASSTLE 490 500 510 520 530 540 KIVNNQAIQD LEIALACGSM KNYKKENLRY EKIIIMTDAD VDGAHIASLL MTFFFLRMPK 550 560 570 580 590 600 LVEDGHLYLA KPPLYRLTQS NKTYYANDEE EKAKLTDKLS KSSKAKIEVG RFKGLGEMMP 610 620 630 640 650 660 MQLKETTMHP EKRSLLKVTL EDFQNVDKIV DDLMGKKPEK RFQFIYEQAL VKMDKIINEL DI

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04311.1.
RefSeq	YP_537400.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK03.
Genome annotation databases
GeneID	3995292.
GenomeReviews	Gene locus RBE_0230 in contig CP000087_GR.
KEGG	rbe:RBE_0230.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RK03.
OMA	KLADCAG
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0230-MON.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR001241. Topo_IIA_B/N. IPR013759. Topo_IIA_B/N_ab. IPR013506. Topo_IIA_B_2. IPR002288. Topo_IIA_B_C. IPR013760. Topo_IIA_cen. IPR018522. TopoIIA_CS. IPR005737. TopoIV_B_Gneg. IPR006171. Toprim_domain. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 1 hit.
Pfam	PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit. [Graphical view]
PRINTS	PR00418. TPI2FAMILY.
SMART	SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit. [Graphical view]
TIGRFAMs	TIGR01055. parE_Gneg. 1 hit.
PROSITE	PS00177. TOPOISOMERASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PARE_RICBR

Accession

Primary (citable) accession number: Q1RK03

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	November 24, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)