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Q1RJZ6

- KTHY_RICBR

UniProt

Q1RJZ6 - KTHY_RICBR

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Protein
Thymidylate kinase
Gene
tmk, RBE_0237
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:RBE_0237
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Thymidylate kinaseUniRule annotation
PRO_0000278012Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0237.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229078.
KOiK00943.
OMAiEPGGCPI.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RJZ6-1 [UniParc]FASTAAdd to Basket

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MSKLKQGTFI TFEGGEGIGK STQCQMLYEY LKSQNIPVIL TREVGGTNVA    50
EKMREILVHT DLLPMSELLQ AMAARYDHMV KKIIPALQAG NIVICDRFID 100
STACYQGLEL ENGIELVYNL HKDLMPPLMP DLTFFIDVES SIAIERVNSR 150
NMSNKFDVRG LDFYNKIYDC FKGLSKKFPE RIVTIKASDL NPEQVHELIK 200
KHLNLI 206
Length:206
Mass (Da):23,458
Last modified:May 16, 2006 - v1
Checksum:i0111CAFFE22D1008
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04318.1.
RefSeqiYP_537407.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04318; ABE04318; RBE_0237.
GeneIDi3995299.
KEGGirbe:RBE_0237.
PATRICi17881783. VBIRicBel102610_0271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04318.1 .
RefSeqi YP_537407.1. NC_007940.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04318 ; ABE04318 ; RBE_0237 .
GeneIDi 3995299.
KEGGi rbe:RBE_0237.
PATRICi 17881783. VBIRicBel102610_0271.

Phylogenomic databases

eggNOGi COG0125.
HOGENOMi HOG000229078.
KOi K00943.
OMAi EPGGCPI.
OrthoDBi EOG64JFSH.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-243-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiKTHY_RICBR
AccessioniPrimary (citable) accession number: Q1RJZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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