Reviewed, UniProtKB/Swiss-Prot Q1RJZ6 (KTHY_RICBR)

Names and origin

Protein names

Recommended name:
    Thymidylate kinase
    EC=2.7.4.9
Alternative name(s):
    dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	RBE_0237

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity.
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Thymidylate kinase HAMAP MF_00165		PRO_0000278012
Regions
	Nucleotide binding	14 – 21	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RJZ6-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 0111CAFFE22D1008	FASTA	206	23,458
	10 20 30 40 50 60 MSKLKQGTFI TFEGGEGIGK STQCQMLYEY LKSQNIPVIL TREVGGTNVA EKMREILVHT 70 80 90 100 110 120 DLLPMSELLQ AMAARYDHMV KKIIPALQAG NIVICDRFID STACYQGLEL ENGIELVYNL 130 140 150 160 170 180 HKDLMPPLMP DLTFFIDVES SIAIERVNSR NMSNKFDVRG LDFYNKIYDC FKGLSKKFPE 190 200 RIVTIKASDL NPEQVHELIK KHLNLI

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04318.1.
RefSeq	YP_537407.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RJZ6.
Genome annotation databases
GeneID	3995299.
GenomeReviews	Gene locus RBE_0237 in contig CP000087_GR.
KEGG	rbe:RBE_0237.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RJZ6.
OMA	VVTTREP
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0237-MON.
Family and domain databases
HAMAP	MF_00165. [Tree]
InterPro	IPR018094. Thymidylate_kin. IPR000062. Thymidylate_kin-like. IPR018095. Thymidylate_kin_CS. [Graphical view]
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_RICBR

Accession

Primary (citable) accession number: Q1RJZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)