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Q1RJZ5

- SYM_RICBR

UniProt

Q1RJZ5 - SYM_RICBR

Protein

Methionine--tRNA ligase

Gene

metG

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotation

    Catalytic activityi

    ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei298 – 2981ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-244-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
    Alternative name(s):
    Methionyl-tRNA synthetaseUniRule annotation
    Short name:
    MetRSUniRule annotation
    Gene namesi
    Name:metGUniRule annotation
    Ordered Locus Names:RBE_0238
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Methionine--tRNA ligasePRO_0000272401Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0238.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RJZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2211"HIGH" regionAdd
    BLAST
    Motifi295 – 2995"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0143.
    HOGENOMiHOG000200401.
    KOiK01874.
    OMAiDGKCPDH.
    OrthoDBiEOG6CVV9B.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_01228. Met_tRNA_synth_type2.
    InterProiIPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RJZ5-1 [UniParc]FASTAAdd to Basket

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    MNNTYYITTP IYYVNDVPHI GHAYTSVASD VIARFMRLSG HEVMFLTGTD    50
    EHGQKVEKAA IDKNIDPQKF TDQTSQSFRH LMTAMHISND DFIRTTEERH 100
    KKAVAIFWQK LLDNGSIYEG FYEGWYAVRD EAFYDESELT ADKLAPTGAA 150
    VEWVKEPSYF FNLSKWQDKL LEFYEANPDF IRPISRRNEV ISFVKSGLKD 200
    LSVSRTTFNW GIKVPNDNKH VIYVWLDALA NYISALGYPD QNSNYGKFWP 250
    ANLQVVGKDI LRFHAVYWPA FLMAAEIPLP KTIMAHGWWT NEGQKISKSL 300
    GNTIDPIKLI EEFGVDQVRY FLMREITFGA DGNFARSNLI TRINSELSNK 350
    IGNLLQRTTS FVYKNNDGKV PAITQDAINK IYELPLLKTA INSAKQNILL 400
    MEKTEINKIL DNIINLAEEA NIYIDSEAPW NLKKTDPEKM LEVLYALLET 450
    LRYIAVMLQA FMPSSAGKML DQLGVNTEER LFKHLSLEFA LTSASDILEP 500
    VIVFPRFEE 509
    Length:509
    Mass (Da):58,359
    Last modified:May 16, 2006 - v1
    Checksum:iFFA102B509977D69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04319.1.
    RefSeqiYP_537408.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04319; ABE04319; RBE_0238.
    GeneIDi3995386.
    KEGGirbe:RBE_0238.
    PATRICi17881785. VBIRicBel102610_0272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04319.1 .
    RefSeqi YP_537408.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RJZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0238.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04319 ; ABE04319 ; RBE_0238 .
    GeneIDi 3995386.
    KEGGi rbe:RBE_0238.
    PATRICi 17881785. VBIRicBel102610_0272.

    Phylogenomic databases

    eggNOGi COG0143.
    HOGENOMi HOG000200401.
    KOi K01874.
    OMAi DGKCPDH.
    OrthoDBi EOG6CVV9B.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-244-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_01228. Met_tRNA_synth_type2.
    InterProi IPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiSYM_RICBR
    AccessioniPrimary (citable) accession number: Q1RJZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3