Q1RJY5 (UBIE_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquinone/menaquinone biosynthesis methyltransferase ubiE
EC=2.1.1.163
EC=2.1.1.201

Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase

Gene names

Name:	ubiE
Ordered Locus Names:	RBE_0248

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP MF_01813
Catalytic activity	A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. HAMAP MF_01813 S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP MF_01813
Pathway	Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. HAMAP MF_01813 Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01813
Sequence similarities	Belongs to the methyltransferase superfamily. UbiE family.

Ontologies

Keywords
Biological process	Menaquinone biosynthesis Ubiquinone biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	menaquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Ubiquinone/menaquinone biosynthesis methyltransferase ubiE HAMAP MF_01813		PRO_0000272373

Sequences

	Sequence		Length	Mass (Da)
	Q1RJY5 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 89B6E9EE4000D9B2	FASTA	248	28,337
	10 20 30 40 50 60 MNQTNFGFKK IKANEKQSLV NSVFSNVADK YDLMNDLMSF GMHRLWKDEF IRQIPNLNSN 70 80 90 100 110 120 ILDVASGSGD IALKLAKKAK DRGSNISLTL SDINEEMLRQ AKKKSIDLNL FQNLKFTVAS 130 140 150 160 170 180 AEELPFPDNS FDYYTIAFGI RNVPDINKAL KEAYRVLKPM GKFICLEFSK VKESLLQDFY 190 200 210 220 230 240 KFYSFNVIPK IGQIITGNKE AYDYLVESID LFPSQDEFRI MIKEAGFEEI NYKNLSGGIV AIHSAYKL

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04329.1.
RefSeq	YP_537418.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RJY5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RJY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995396.
GenomeReviews	Gene locus RBE_0248 in contig CP000087_GR.
KEGG	rbe:RBE_0248.
PATRIC	17881809. VBIRicBel102610_0284.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2226.
HOGENOM	HBG559580.
OMA	PYQYLVE.
ProtClustDB	PRK00216.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0248-MONOMER.
Family and domain databases
HAMAP	MF_01813. UbiE_methyltran. [Tree]
InterPro	IPR004033. UbiE/COQ5_MeTrFase. IPR023576. UbiE/COQ5_MeTrFase_CS. [Graphical view]
KO	K03183.
PANTHER	PTHR10108:SF24. UbiE/COQ5mtfrase. 1 hit.
Pfam	PF01209. Ubie_methyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITE	PS01183. UBIE_1. 1 hit. PS01184. UBIE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIE_RICBR

Accession

Primary (citable) accession number: Q1RJY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program