Q1RJX8 (CTAA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme A synthase
Short name=HAS
EC=1.3.-.-

Alternative name(s):
Cytochrome aa3-controlling protein

Gene names

Name:	ctaA
Synonyms:	coxW
Ordered Locus Names:	RBE_0255

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group By similarity. HAMAP MF_01665
Pathway	Porphyrin metabolism; heme A biosynthesis; heme A from heme O: step 1/1. HAMAP MF_01665
Subunit structure	Interacts with CtaB By similarity. HAMAP MF_01665
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01665.
Sequence similarities	Belongs to the COX15/CtaA family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Heme biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme a biosynthetic process Inferred from electronic annotation. Source: InterPro protein complex assembly Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Heme A synthase HAMAP MF_01665		PRO_0000349073
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Transmembrane	284 – 304	21	Helical; Potential
	Transmembrane	307 – 327	21	Helical; Potential
Sites
	Binding site	315	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RJX8 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: DC2F8EB4DFC36593	FASTA	336	38,231
	10 20 30 40 50 60 MQKNLTRWLL TCCIMVVAMI IVGGITRLTD SGLSIVEWRP VTGILPPFSY DTWQAEFAKY 70 80 90 100 110 120 KAFPEYNAVN YGMTLSEFKF IYLLEFVHRL LGRATGLIYI LPLIYFYFKG IIKNRDILSY 130 140 150 160 170 180 IIVLLLFCVQ GFMGWYMVKS GLVNHPSVSH FRLAFHLIIA VIIYHLLFYK LVKNCCDILL 190 200 210 220 230 240 IPSQINLKLP LIFSVAAIAM IYVQIFLGAL VAGLDAGLIY NSFPLMGGNF IPIEIKDNFI 250 260 270 280 290 300 SFKNWYDPVF VQFIHRLGAY SLSIIVIALI ISLLKVKNPK LNKVAFYLSI ALLIQLSTGV 310 320 330 ITLLYHVPII AASMHQFFAI VLLSVVIWCY SLIKNS

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04336.1.
RefSeq	YP_537425.1. NC_007940.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RJX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995879.
GenomeReviews	Gene locus RBE_0255 in contig CP000087_GR.
KEGG	rbe:RBE_0255.
PATRIC	17881823. VBIRicBel102610_0291.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1612.
HOGENOM	HBG628966.
OMA	KTIFWWE.
ProtClustDB	CLSK864993.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0255-MONOMER.
Family and domain databases
HAMAP	MF_01665. HemeA_synth_type2. [Tree]
InterPro	IPR003780. HemeA_syn. IPR023754. HemeA_Synthase_type2. [Graphical view]
KO	K02259.
Pfam	PF02628. COX15-CtaA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTAA_RICBR

Accession

Primary (citable) accession number: Q1RJX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program