Q1RJX8 (CTAA_RICBR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Heme A synthase Short name=HAS EC=1.3.-.- Alternative name(s): Cytochrome aa3-controlling protein | ||||||
| Gene names |
| ||||||
| Organism | Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 336407 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia |
Protein attributes
| Sequence length | 336 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group By similarity. HAMAP MF_01665 |
| Pathway | Porphyrin metabolism; heme A biosynthesis; heme A from heme O: step 1/1. HAMAP MF_01665 |
| Subunit structure | Interacts with CtaB By similarity. HAMAP MF_01665 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01665. |
| Sequence similarities | Belongs to the COX15/CtaA family. Type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Heme biosynthesis |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | heme a biosynthetic process Inferred from electronic annotation. Source: InterPro protein complex assemblyInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | oxidoreductase activity, acting on the CH-CH group of donors Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 336 | 336 | Heme A synthase HAMAP MF_01665 | PRO_0000349073 | |||||
Regions | |||||||||
| Transmembrane | 5 – 25 | 21 | Helical; Potential | ||||||
| Transmembrane | 92 – 112 | 21 | Helical; Potential | ||||||
| Transmembrane | 117 – 137 | 21 | Helical; Potential | ||||||
| Transmembrane | 153 – 173 | 21 | Helical; Potential | ||||||
| Transmembrane | 191 – 211 | 21 | Helical; Potential | ||||||
| Transmembrane | 253 – 273 | 21 | Helical; Potential | ||||||
| Transmembrane | 284 – 304 | 21 | Helical; Potential | ||||||
| Transmembrane | 307 – 327 | 21 | Helical; Potential | ||||||
Sites | |||||||||
| Binding site | 315 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000087 Genomic DNA. Translation: ABE04336.1. |
| RefSeq | YP_537425.1. NC_007940.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q1RJX8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3995879. |
| GenomeReviews | Gene locus RBE_0255 in contig CP000087_GR. |
| KEGG | rbe:RBE_0255. |
| PATRIC | 17881823. VBIRicBel102610_0291. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1612. |
| HOGENOM | HBG628966. |
| OMA | KTIFWWE. |
| ProtClustDB | CLSK864993. |
Enzyme and pathway databases | |
| BioCyc | RBEL336407:RBE_0255-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01665. HemeA_synth_type2. [Tree] |
| InterPro | IPR003780. HemeA_syn. IPR023754. HemeA_Synthase_type2. [Graphical view] |
| KO | K02259. |
| Pfam | PF02628. COX15-CtaA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CTAA_RICBR | ||||||||
| Accession | Primary (citable) accession number: Q1RJX8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Rickettsia bellii strain RML369-C Rickettsia bellii (strain RML369-C): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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