Q1RJX7 (RLUC_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal large subunit pseudouridine synthase C
EC=5.4.99.24

Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C

Gene names

Name:	rluC
Ordered Locus Names:	RBE_0256

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA By similarity.
Catalytic activity	23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).
Sequence similarities	Belongs to the pseudouridine synthase RluA family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Biological process	rRNA processing
Ligand	RNA-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Ribosomal large subunit pseudouridine synthase C		PRO_0000286664
Regions
	Domain	11 – 70	60	S4 RNA-binding
Sites
	Active site	140	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RJX7 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 8B2751DF8A02902A	FASTA	301	33,932
	10 20 30 40 50 60 MIITVNSPIA SRLDKYLRRL YPLLTQGVIE KALRQKQIIV NSKKAEASLR VVEGDEIFIH 70 80 90 100 110 120 DKFNLPIAQP TKLVFTDAEI TLAKKITTEY LIYEDDNIIA INKPAGLATQ GGSKINLSVD 130 140 150 160 170 180 SALKYLNSQG ADFKLVHRLD KETSGLLLIA KNYVSSVKLH DAFKEKLVEK TYLAVTYGKP 190 200 210 220 230 240 IKDQGEVKTN IEKSKGSIPK ITDINDNNGK LAITYYKLLK SLTNNLFLVE FIPITGRMHQ 250 260 270 280 290 300 LRLHAKLLGC PIFGDNKYGN DKLMPYSKYM FLHANNIVLS KKVFGKEVNL EAKLPSYFNR V

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04337.1.
RefSeq	YP_537426.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RJX7.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0256.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04337; ABE04337; RBE_0256.
GeneID	3995880.
KEGG	rbe:RBE_0256.
PATRIC	17881825. VBIRicBel102610_0292.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0564.
HOGENOM	HOG000275914.
KO	K06179.
OMA	DINDNNG.
ProtClustDB	CLSK2517043.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-262-MONOMER.
Family and domain databases
Gene3D	3.10.290.10. 1 hit.
InterPro	IPR020103. PsdUridine_synth_cat_dom. IPR006224. PsdUridine_synth_RluC/D_CS. IPR006145. PsdUridine_synth_RsuA/RluD. IPR002942. S4_RNA-bd. [Graphical view]
Pfam	PF00849. PseudoU_synth_2. 1 hit. PF01479. S4. 1 hit. [Graphical view]
SMART	SM00363. S4. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit.
PROSITE	PS01129. PSI_RLU. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RLUC_RICBR

Accession

Primary (citable) accession number: Q1RJX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program