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Q1RJX7

- RLUC_RICBR

UniProt

Q1RJX7 - RLUC_RICBR

Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-262-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
    Alternative name(s):
    23S rRNA pseudouridine(955/2504/2580) synthase
    rRNA pseudouridylate synthase C
    rRNA-uridine isomerase C
    Gene namesi
    Name:rluC
    Ordered Locus Names:RBE_0256
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Ribosomal large subunit pseudouridine synthase CPRO_0000286664Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RJX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 7060S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    HOGENOMiHOG000275914.
    KOiK06179.
    OMAiLNYKGAD.
    OrthoDBiEOG6P070X.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RJX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIITVNSPIA SRLDKYLRRL YPLLTQGVIE KALRQKQIIV NSKKAEASLR    50
    VVEGDEIFIH DKFNLPIAQP TKLVFTDAEI TLAKKITTEY LIYEDDNIIA 100
    INKPAGLATQ GGSKINLSVD SALKYLNSQG ADFKLVHRLD KETSGLLLIA 150
    KNYVSSVKLH DAFKEKLVEK TYLAVTYGKP IKDQGEVKTN IEKSKGSIPK 200
    ITDINDNNGK LAITYYKLLK SLTNNLFLVE FIPITGRMHQ LRLHAKLLGC 250
    PIFGDNKYGN DKLMPYSKYM FLHANNIVLS KKVFGKEVNL EAKLPSYFNR 300
    V 301
    Length:301
    Mass (Da):33,932
    Last modified:May 16, 2006 - v1
    Checksum:i8B2751DF8A02902A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04337.1.
    RefSeqiWP_011476949.1. NC_007940.1.
    YP_537426.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04337; ABE04337; RBE_0256.
    GeneIDi3995880.
    KEGGirbe:RBE_0256.
    PATRICi17881825. VBIRicBel102610_0292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04337.1 .
    RefSeqi WP_011476949.1. NC_007940.1.
    YP_537426.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RJX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04337 ; ABE04337 ; RBE_0256 .
    GeneIDi 3995880.
    KEGGi rbe:RBE_0256.
    PATRICi 17881825. VBIRicBel102610_0292.

    Phylogenomic databases

    eggNOGi COG0564.
    HOGENOMi HOG000275914.
    KOi K06179.
    OMAi LNYKGAD.
    OrthoDBi EOG6P070X.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-262-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiRLUC_RICBR
    AccessioniPrimary (citable) accession number: Q1RJX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3