Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1RJX7 (RLUC_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal large subunit pseudouridine synthase C

EC=5.4.99.24
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene names
Name:rluC
Ordered Locus Names:RBE_0256
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA By similarity.

Catalytic activity

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Biological processrRNA processing
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Ribosomal large subunit pseudouridine synthase C
PRO_0000286664

Regions

Domain11 – 7060S4 RNA-binding

Sites

Active site1401 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RJX7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 8B2751DF8A02902A

FASTA30133,932
        10         20         30         40         50         60 
MIITVNSPIA SRLDKYLRRL YPLLTQGVIE KALRQKQIIV NSKKAEASLR VVEGDEIFIH 

        70         80         90        100        110        120 
DKFNLPIAQP TKLVFTDAEI TLAKKITTEY LIYEDDNIIA INKPAGLATQ GGSKINLSVD 

       130        140        150        160        170        180 
SALKYLNSQG ADFKLVHRLD KETSGLLLIA KNYVSSVKLH DAFKEKLVEK TYLAVTYGKP 

       190        200        210        220        230        240 
IKDQGEVKTN IEKSKGSIPK ITDINDNNGK LAITYYKLLK SLTNNLFLVE FIPITGRMHQ 

       250        260        270        280        290        300 
LRLHAKLLGC PIFGDNKYGN DKLMPYSKYM FLHANNIVLS KKVFGKEVNL EAKLPSYFNR 


V 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04337.1.
RefSeqYP_537426.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RJX7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04337; ABE04337; RBE_0256.
GeneID3995880.
KEGGrbe:RBE_0256.
PATRIC17881825. VBIRicBel102610_0292.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0564.
HOGENOMHOG000275914.
KOK06179.
OMALNYKGAD.
OrthoDBEOG6P070X.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-262-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLUC_RICBR
AccessionPrimary (citable) accession number: Q1RJX7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names