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Q1RJX4

- ODPA_RICBR

UniProt

Q1RJX4 - ODPA_RICBR

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-265-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Ordered Locus Names:RBE_0259
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit alphaPRO_0000288752Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi336407.RBE_0259.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RJX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    HOGENOMiHOG000281336.
    KOiK00161.
    OMAiEYAMGTS.
    OrthoDBiEOG6JMMWC.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RJX4-1 [UniParc]FASTAAdd to Basket

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    MDIKLGKYKP VKEEYIKSFK DMLLLRRFEE KCGQLYGMGE IGGFCHLYIG    50
    QEAVISAVDM VKQKEDSMVT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS 100
    KGKGGSMHLF DVPNKFYGGH GIVGAQVPIG TGLAFAEKYN GTNNICFTFL 150
    GDGAVNQGQV YEAFNMAALW GLPVVYIIEN NEYSMGTSVA RSTFMRDLYK 200
    KGESFGIKGF QLNGMDFEEM YDGVKQAAEY VRENSMPLIL EVKTYRYRGH 250
    SMSDPAKYRS KEEVETYKER DPITEIRKII LENNYASEAD LKEIEQSVKE 300
    IVKEAVEFSE NSPLPNEEEL YTQIYV 326
    Length:326
    Mass (Da):36,853
    Last modified:May 16, 2006 - v1
    Checksum:i36F16A727359D2E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04340.1.
    RefSeqiYP_537429.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04340; ABE04340; RBE_0259.
    GeneIDi3995883.
    KEGGirbe:RBE_0259.
    PATRICi17881831. VBIRicBel102610_0295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04340.1 .
    RefSeqi YP_537429.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RJX4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04340 ; ABE04340 ; RBE_0259 .
    GeneIDi 3995883.
    KEGGi rbe:RBE_0259.
    PATRICi 17881831. VBIRicBel102610_0295.

    Phylogenomic databases

    eggNOGi COG1071.
    HOGENOMi HOG000281336.
    KOi K00161.
    OMAi EYAMGTS.
    OrthoDBi EOG6JMMWC.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-265-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiODPA_RICBR
    AccessioniPrimary (citable) accession number: Q1RJX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names

    External Data

    Dasty 3