Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:RBE_0259
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002887521 – 326Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST326

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliQ1RJX4
SMRiQ1RJX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000281336
KOiK00161
OMAiYRSHGFT
OrthoDBiPOG091H04RI

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RJX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKLGKYKP VKEEYIKSFK DMLLLRRFEE KCGQLYGMGE IGGFCHLYIG
60 70 80 90 100
QEAVISAVDM VKQKEDSMVT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS
110 120 130 140 150
KGKGGSMHLF DVPNKFYGGH GIVGAQVPIG TGLAFAEKYN GTNNICFTFL
160 170 180 190 200
GDGAVNQGQV YEAFNMAALW GLPVVYIIEN NEYSMGTSVA RSTFMRDLYK
210 220 230 240 250
KGESFGIKGF QLNGMDFEEM YDGVKQAAEY VRENSMPLIL EVKTYRYRGH
260 270 280 290 300
SMSDPAKYRS KEEVETYKER DPITEIRKII LENNYASEAD LKEIEQSVKE
310 320
IVKEAVEFSE NSPLPNEEEL YTQIYV
Length:326
Mass (Da):36,853
Last modified:May 16, 2006 - v1
Checksum:i36F16A727359D2E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA Translation: ABE04340.1
RefSeqiWP_011476952.1, NC_007940.1

Genome annotation databases

EnsemblBacteriaiABE04340; ABE04340; RBE_0259
KEGGirbe:RBE_0259

Similar proteinsi

Entry informationi

Entry nameiODPA_RICBR
AccessioniPrimary (citable) accession number: Q1RJX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health