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Q1RJX3

- ODPB_RICBR

UniProt

Q1RJX3 - ODPB_RICBR

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Protein
Pyruvate dehydrogenase E1 component subunit beta
Gene
pdhB, RBE_0260
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Thiamine pyrophosphate By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process from pyruvate Source: InterPro
  2. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:RBE_0260
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Pyruvate dehydrogenase E1 component subunit beta
PRO_0000288760Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi336407.RBE_0260.

Structurei

3D structure databases

ProteinModelPortaliQ1RJX3.
SMRiQ1RJX3. Positions 1-322.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0022.
HOGENOMiHOG000281450.
KOiK00162.
OMAiYASWYAH.
OrthoDBiEOG6JQH4C.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PANTHERiPTHR11624:SF56. PTHR11624:SF56. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RJX3-1 [UniParc]FASTAAdd to Basket

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MQITVREALR DAMQEEMIRD DKVFVMGEEV AEYQGAYKVT QGLLEQFGPK    50
RVIDTPITEY GFAGLAVGAA FAGLRPIVEF MTFNFAMQAM DHIVNSAAKT 100
HYMSGGQVRC PIVFRGPNGA ASRVAAQHSQ NYAACYSYIP GLKVVAPYSA 150
EDHKGLMITA IRDDNPVIFL ENEILYGHSF DISENVEPIP FGKAKVLKEG 200
DSVTIVTFSI QVKLALDAAN ILQSDNINCE VIDLRTIKPL DIDTIIESVK 250
KTGRLVVIEE GWFFAGIGAT IAAIVMKEAF DYLDAPVEIV SGKDVPLPYA 300
VNLEKLALPS EYDVINAVKK VCYIK 325
Length:325
Mass (Da):35,708
Last modified:May 16, 2006 - v1
Checksum:i89AC46026246C64B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04341.1.
RefSeqiWP_011476953.1. NC_007940.1.
YP_537430.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04341; ABE04341; RBE_0260.
GeneIDi3995884.
KEGGirbe:RBE_0260.
PATRICi17881833. VBIRicBel102610_0296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04341.1 .
RefSeqi WP_011476953.1. NC_007940.1.
YP_537430.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RJX3.
SMRi Q1RJX3. Positions 1-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04341 ; ABE04341 ; RBE_0260 .
GeneIDi 3995884.
KEGGi rbe:RBE_0260.
PATRICi 17881833. VBIRicBel102610_0296.

Phylogenomic databases

eggNOGi COG0022.
HOGENOMi HOG000281450.
KOi K00162.
OMAi YASWYAH.
OrthoDBi EOG6JQH4C.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-266-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProi IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view ]
PANTHERi PTHR11624:SF56. PTHR11624:SF56. 1 hit.
Pfami PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiODPB_RICBR
AccessioniPrimary (citable) accession number: Q1RJX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names

External Data

Dasty 3

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