Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1RJU4 (IDH_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Ordered Locus Names:RBE_0289
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Isocitrate dehydrogenase [NADP]
PRO_0000292202

Sites

Metal binding2081Magnesium or manganese By similarity
Metal binding2321Magnesium or manganese By similarity
Metal binding2361Magnesium or manganese By similarity
Binding site891Substrate By similarity
Binding site991Substrate By similarity
Binding site1211Substrate By similarity
Binding site2081Substrate By similarity
Site1281Critical for catalysis By similarity
Site1751Critical for catalysis By similarity

Amino acid modifications

Modified residue831Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RJU4 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: D02F3B5F38A5FF9D

FASTA48353,959
        10         20         30         40         50         60 
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYVKHY SSGISEQSWE 

        70         80         90        100        110        120 
SIERTGVILK APITTPQGGG YKSLNVTIRK TLQLFANIRP SVSFYPFTKT LHPNLNLTII 

       130        140        150        160        170        180 
RENEEDLYAG IEYRQTHNMY ESVKLISRTG CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK 

       190        200        210        220        230        240 
FSDGIFHKVF NEIAKEYPQI NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGEHYAMF EAVHGSAPDI AGQDIANPSG LLNAAIMMLV HIGQGDIATL 

       310        320        330        340        350        360 
IENAWKKTIE DGMHTADIYN KDHSTKKVGT KEFAEEVVKR LGQKPEKLAK ADYPLVTKKQ 

       370        380        390        400        410        420 
ESNTTYKINT KEVKKLVGTD IFVGMNVASA HDIADKVNKL DIGNFELKTI SSKGLKLWPR 

       430        440        450        460        470        480 
DTRFETISDH WCCRFMAKDG VELKHLDITK LLETLSKANI DFIKVENLFE FDGAAGYSLA 


QGE 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04370.1.
RefSeqYP_537459.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RJU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04370; ABE04370; RBE_0289.
GeneID3995512.
KEGGrbe:RBE_0289.
PATRIC17881891. VBIRicBel102610_0325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0473.
HOGENOMHOG000021113.
KOK00031.
OMAVDSTAMN.
OrthoDBEOG65XN31.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-295-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR02924. ICDH_alpha. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_RICBR
AccessionPrimary (citable) accession number: Q1RJU4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names