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Q1RJU4

- IDH_RICBR

UniProt

Q1RJU4 - IDH_RICBR

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Sitei128 – 1281Critical for catalysisBy similarity
Sitei175 – 1751Critical for catalysisBy similarity
Metal bindingi208 – 2081Magnesium or manganeseBy similarity
Binding sitei208 – 2081SubstrateBy similarity
Metal bindingi232 – 2321Magnesium or manganeseBy similarity
Metal bindingi236 – 2361Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-295-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:RBE_0289
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000292202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0289.

Structurei

3D structure databases

ProteinModelPortaliQ1RJU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiVDSTAMN.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RJU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYVKHY
60 70 80 90 100
SSGISEQSWE SIERTGVILK APITTPQGGG YKSLNVTIRK TLQLFANIRP
110 120 130 140 150
SVSFYPFTKT LHPNLNLTII RENEEDLYAG IEYRQTHNMY ESVKLISRTG
160 170 180 190 200
CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK FSDGIFHKVF NEIAKEYPQI
210 220 230 240 250
NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS
260 270 280 290 300
ANIGEHYAMF EAVHGSAPDI AGQDIANPSG LLNAAIMMLV HIGQGDIATL
310 320 330 340 350
IENAWKKTIE DGMHTADIYN KDHSTKKVGT KEFAEEVVKR LGQKPEKLAK
360 370 380 390 400
ADYPLVTKKQ ESNTTYKINT KEVKKLVGTD IFVGMNVASA HDIADKVNKL
410 420 430 440 450
DIGNFELKTI SSKGLKLWPR DTRFETISDH WCCRFMAKDG VELKHLDITK
460 470 480
LLETLSKANI DFIKVENLFE FDGAAGYSLA QGE
Length:483
Mass (Da):53,959
Last modified:May 16, 2006 - v1
Checksum:iD02F3B5F38A5FF9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04370.1.
RefSeqiWP_011476981.1. NC_007940.1.
YP_537459.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04370; ABE04370; RBE_0289.
GeneIDi3995512.
KEGGirbe:RBE_0289.
PATRICi17881891. VBIRicBel102610_0325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04370.1 .
RefSeqi WP_011476981.1. NC_007940.1.
YP_537459.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RJU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04370 ; ABE04370 ; RBE_0289 .
GeneIDi 3995512.
KEGGi rbe:RBE_0289.
PATRICi 17881891. VBIRicBel102610_0325.

Phylogenomic databases

eggNOGi COG0473.
HOGENOMi HOG000021113.
KOi K00031.
OMAi VDSTAMN.
OrthoDBi EOG65XN31.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-295-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiIDH_RICBR
AccessioniPrimary (citable) accession number: Q1RJU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 16, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3