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Q1RJU4

- IDH_RICBR

UniProt

Q1RJU4 - IDH_RICBR

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Sitei128 – 1281Critical for catalysisBy similarity
    Sitei175 – 1751Critical for catalysisBy similarity
    Metal bindingi208 – 2081Magnesium or manganeseBy similarity
    Binding sitei208 – 2081SubstrateBy similarity
    Metal bindingi232 – 2321Magnesium or manganeseBy similarity
    Metal bindingi236 – 2361Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-295-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:RBE_0289
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000292202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei83 – 831PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0289.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RJU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0473.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiVDSTAMN.
    OrthoDBiEOG65XN31.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RJU4-1 [UniParc]FASTAAdd to Basket

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    MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYVKHY    50
    SSGISEQSWE SIERTGVILK APITTPQGGG YKSLNVTIRK TLQLFANIRP 100
    SVSFYPFTKT LHPNLNLTII RENEEDLYAG IEYRQTHNMY ESVKLISRTG 150
    CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK FSDGIFHKVF NEIAKEYPQI 200
    NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS 250
    ANIGEHYAMF EAVHGSAPDI AGQDIANPSG LLNAAIMMLV HIGQGDIATL 300
    IENAWKKTIE DGMHTADIYN KDHSTKKVGT KEFAEEVVKR LGQKPEKLAK 350
    ADYPLVTKKQ ESNTTYKINT KEVKKLVGTD IFVGMNVASA HDIADKVNKL 400
    DIGNFELKTI SSKGLKLWPR DTRFETISDH WCCRFMAKDG VELKHLDITK 450
    LLETLSKANI DFIKVENLFE FDGAAGYSLA QGE 483
    Length:483
    Mass (Da):53,959
    Last modified:May 16, 2006 - v1
    Checksum:iD02F3B5F38A5FF9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04370.1.
    RefSeqiWP_011476981.1. NC_007940.1.
    YP_537459.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04370; ABE04370; RBE_0289.
    GeneIDi3995512.
    KEGGirbe:RBE_0289.
    PATRICi17881891. VBIRicBel102610_0325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04370.1 .
    RefSeqi WP_011476981.1. NC_007940.1.
    YP_537459.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RJU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04370 ; ABE04370 ; RBE_0289 .
    GeneIDi 3995512.
    KEGGi rbe:RBE_0289.
    PATRICi 17881891. VBIRicBel102610_0325.

    Phylogenomic databases

    eggNOGi COG0473.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi VDSTAMN.
    OrthoDBi EOG65XN31.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-295-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiIDH_RICBR
    AccessioniPrimary (citable) accession number: Q1RJU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3