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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1UniRule annotation
Short name:
RF-1UniRule annotation
Gene namesi
Name:prfAUniRule annotation
Ordered Locus Names:RBE_0298
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002633391 – 357Peptide chain release factor 1Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N5-methylglutamineUniRule annotation1

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation

Keywords - PTMi

Methylation

Structurei

3D structure databases

ProteinModelPortaliQ1RJT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000074815.
KOiK02835.
OMAiGVWAHLK.
OrthoDBiPOG091H021P.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RJT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISSFSDNL TKILGKYEDL SEKLSSGIGG EEFVKASKEY ADLEDIVQKI
60 70 80 90 100
KEYNKAKAEL EEANNFKQEP SLDKATLEMI EEEIRNLEDS LPTLERSVKI
110 120 130 140 150
ALLPKDEADS KSAIIEIRAG TGGEEAALFA AKLFNMYQRY AELKGWRFEI
160 170 180 190 200
LSIDETGIGG YKEVSASIKG KDVFSKLKFE SGVHRVQRVP ETESQGRIHT
210 220 230 240 250
SAATVAVLPE VEDVDIKLEE KDLRIDTYRA SGAGGQHVNT TDSAVRITHI
260 270 280 290 300
PTGITVALQD EKSQHKNKAK ALKILRARIY EEERRKKDQE RANNRRKQIG
310 320 330 340 350
SGDRSERIRT YNFPQGRVSD HRINLTLYKI DEVINGQLDE FIEALIANDE

AKKLSDI
Length:357
Mass (Da):40,217
Last modified:May 16, 2006 - v1
Checksum:i530AAD165D1027C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04379.1.
RefSeqiWP_011476990.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04379; ABE04379; RBE_0298.
KEGGirbe:RBE_0298.
PATRICi17881911. VBIRicBel102610_0335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04379.1.
RefSeqiWP_011476990.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RJT5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE04379; ABE04379; RBE_0298.
KEGGirbe:RBE_0298.
PATRICi17881911. VBIRicBel102610_0335.

Phylogenomic databases

HOGENOMiHOG000074815.
KOiK02835.
OMAiGVWAHLK.
OrthoDBiPOG091H021P.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1_RICBR
AccessioniPrimary (citable) accession number: Q1RJT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.