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Q1RJS2

- SYL_RICBR

UniProt

Q1RJS2 - SYL_RICBR

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Protein
Leucine--tRNA ligase
Gene
leuS, RBE_0311
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei603 – 6031ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-317-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RBE_0311
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Leucine--tRNA ligaseUniRule annotation
PRO_0000277915Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0311.

Structurei

3D structure databases

ProteinModelPortaliQ1RJS2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 4511"HIGH" regionUniRule annotation
Add
BLAST
Motifi600 – 6045"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RJS2-1 [UniParc]FASTAAdd to Basket

« Hide

MNIEQKWQQI WQEEKAFEVP NESSKPKYYV LEMLPYPSGK IHVGHVRNYS    50
IGDVVARFMT MQGFNVLHPM GWDSFGLPAE NAAIKNNSHP KEWTYSNIEN 100
MKKQLKSMGF SYDWSREINS CDPDYYKHEQ KFFLELYERN LAYQKESLVN 150
WDPVDNTVLA NEQVVDGRGW RSGAIVEKRY LKQWFLKITN YAEELLNEIP 200
NLTEWPEAVR SMQEKWIGKS VGANFRFKIK DNEDVIEVFS TKPETIFGAS 250
FVGIAFNHPI IEKLVSKTPE IENFIAKCSN ITGSAEFDKA EKEGIFTGLY 300
VVHPFDSNIT LPVVITNFVL MDYGTGAVFG CPAHDQRDHE LAVKINLPIK 350
QVIEADTDVQ KAAYTEDGII INSGFLNGLS TNEAKQRVIE EFEKLGIGKR 400
TINYRLKDWG ISRQRFWGCP IPIIHCDSCG LVPVPDSDLP VTLPDDVKFD 450
GHGNPLDNHP TWKHVNCPKC SKPAIRETDT FDTFFESSWY FTRYCNSQAL 500
EMTDKKACDY WLPVDKYIGG IEHAVMHLLY ARFFTKVMNE QDYVSVREPF 550
KGLFTQGMVL HATYKDEHNN WLYPEEVIKK GNEFFHKENG GLVTQGRIEK 600
MSKSKKNLID LETMQQQYGA DAIRFFVLSD SPPEKDLEWS ASGIEGSARF 650
INKLEQMQET IIKLSDNKNT NKELKRLIHF TIKHVAEDIK HFALNRAIAR 700
MRELFNAISS EINKEEIDVQ NAKHGFNVLI QLLNPFIPHI TEEIWQKLGH 750
KTFLYNAAFP TFDESMLELD TYVIAVQVNG KLRDTYEFNT SASEDEIKQI 800
AINLPKVQKF LEGKEPKKII LVPKKIINII C 831
Length:831
Mass (Da):95,795
Last modified:May 16, 2006 - v1
Checksum:i017EDD2BC037ACA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04392.1.
RefSeqiYP_537481.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04392; ABE04392; RBE_0311.
GeneIDi3996285.
KEGGirbe:RBE_0311.
PATRICi17881943. VBIRicBel102610_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04392.1 .
RefSeqi YP_537481.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RJS2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04392 ; ABE04392 ; RBE_0311 .
GeneIDi 3996285.
KEGGi rbe:RBE_0311.
PATRICi 17881943. VBIRicBel102610_0351.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-317-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiSYL_RICBR
AccessioniPrimary (citable) accession number: Q1RJS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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