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Q1RJS2

- SYL_RICBR

UniProt

Q1RJS2 - SYL_RICBR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei603 – 6031ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-317-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RBE_0311
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 831831Leucine--tRNA ligasePRO_0000277915Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RJS2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 4511"HIGH" regionAdd
    BLAST
    Motifi600 – 6045"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RJS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIEQKWQQI WQEEKAFEVP NESSKPKYYV LEMLPYPSGK IHVGHVRNYS    50
    IGDVVARFMT MQGFNVLHPM GWDSFGLPAE NAAIKNNSHP KEWTYSNIEN 100
    MKKQLKSMGF SYDWSREINS CDPDYYKHEQ KFFLELYERN LAYQKESLVN 150
    WDPVDNTVLA NEQVVDGRGW RSGAIVEKRY LKQWFLKITN YAEELLNEIP 200
    NLTEWPEAVR SMQEKWIGKS VGANFRFKIK DNEDVIEVFS TKPETIFGAS 250
    FVGIAFNHPI IEKLVSKTPE IENFIAKCSN ITGSAEFDKA EKEGIFTGLY 300
    VVHPFDSNIT LPVVITNFVL MDYGTGAVFG CPAHDQRDHE LAVKINLPIK 350
    QVIEADTDVQ KAAYTEDGII INSGFLNGLS TNEAKQRVIE EFEKLGIGKR 400
    TINYRLKDWG ISRQRFWGCP IPIIHCDSCG LVPVPDSDLP VTLPDDVKFD 450
    GHGNPLDNHP TWKHVNCPKC SKPAIRETDT FDTFFESSWY FTRYCNSQAL 500
    EMTDKKACDY WLPVDKYIGG IEHAVMHLLY ARFFTKVMNE QDYVSVREPF 550
    KGLFTQGMVL HATYKDEHNN WLYPEEVIKK GNEFFHKENG GLVTQGRIEK 600
    MSKSKKNLID LETMQQQYGA DAIRFFVLSD SPPEKDLEWS ASGIEGSARF 650
    INKLEQMQET IIKLSDNKNT NKELKRLIHF TIKHVAEDIK HFALNRAIAR 700
    MRELFNAISS EINKEEIDVQ NAKHGFNVLI QLLNPFIPHI TEEIWQKLGH 750
    KTFLYNAAFP TFDESMLELD TYVIAVQVNG KLRDTYEFNT SASEDEIKQI 800
    AINLPKVQKF LEGKEPKKII LVPKKIINII C 831
    Length:831
    Mass (Da):95,795
    Last modified:May 16, 2006 - v1
    Checksum:i017EDD2BC037ACA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04392.1.
    RefSeqiYP_537481.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04392; ABE04392; RBE_0311.
    GeneIDi3996285.
    KEGGirbe:RBE_0311.
    PATRICi17881943. VBIRicBel102610_0351.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04392.1 .
    RefSeqi YP_537481.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RJS2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04392 ; ABE04392 ; RBE_0311 .
    GeneIDi 3996285.
    KEGGi rbe:RBE_0311.
    PATRICi 17881943. VBIRicBel102610_0351.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-317-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiSYL_RICBR
    AccessioniPrimary (citable) accession number: Q1RJS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3