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Q1RJS2

- SYL_RICBR

UniProt

Q1RJS2 - SYL_RICBR

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei603 – 6031ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-317-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RBE_0311
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Leucine--tRNA ligasePRO_0000277915Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0311.

Structurei

3D structure databases

ProteinModelPortaliQ1RJS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 4511"HIGH" regionAdd
BLAST
Motifi600 – 6045"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RJS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIEQKWQQI WQEEKAFEVP NESSKPKYYV LEMLPYPSGK IHVGHVRNYS
60 70 80 90 100
IGDVVARFMT MQGFNVLHPM GWDSFGLPAE NAAIKNNSHP KEWTYSNIEN
110 120 130 140 150
MKKQLKSMGF SYDWSREINS CDPDYYKHEQ KFFLELYERN LAYQKESLVN
160 170 180 190 200
WDPVDNTVLA NEQVVDGRGW RSGAIVEKRY LKQWFLKITN YAEELLNEIP
210 220 230 240 250
NLTEWPEAVR SMQEKWIGKS VGANFRFKIK DNEDVIEVFS TKPETIFGAS
260 270 280 290 300
FVGIAFNHPI IEKLVSKTPE IENFIAKCSN ITGSAEFDKA EKEGIFTGLY
310 320 330 340 350
VVHPFDSNIT LPVVITNFVL MDYGTGAVFG CPAHDQRDHE LAVKINLPIK
360 370 380 390 400
QVIEADTDVQ KAAYTEDGII INSGFLNGLS TNEAKQRVIE EFEKLGIGKR
410 420 430 440 450
TINYRLKDWG ISRQRFWGCP IPIIHCDSCG LVPVPDSDLP VTLPDDVKFD
460 470 480 490 500
GHGNPLDNHP TWKHVNCPKC SKPAIRETDT FDTFFESSWY FTRYCNSQAL
510 520 530 540 550
EMTDKKACDY WLPVDKYIGG IEHAVMHLLY ARFFTKVMNE QDYVSVREPF
560 570 580 590 600
KGLFTQGMVL HATYKDEHNN WLYPEEVIKK GNEFFHKENG GLVTQGRIEK
610 620 630 640 650
MSKSKKNLID LETMQQQYGA DAIRFFVLSD SPPEKDLEWS ASGIEGSARF
660 670 680 690 700
INKLEQMQET IIKLSDNKNT NKELKRLIHF TIKHVAEDIK HFALNRAIAR
710 720 730 740 750
MRELFNAISS EINKEEIDVQ NAKHGFNVLI QLLNPFIPHI TEEIWQKLGH
760 770 780 790 800
KTFLYNAAFP TFDESMLELD TYVIAVQVNG KLRDTYEFNT SASEDEIKQI
810 820 830
AINLPKVQKF LEGKEPKKII LVPKKIINII C
Length:831
Mass (Da):95,795
Last modified:May 16, 2006 - v1
Checksum:i017EDD2BC037ACA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04392.1.
RefSeqiYP_537481.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04392; ABE04392; RBE_0311.
GeneIDi3996285.
KEGGirbe:RBE_0311.
PATRICi17881943. VBIRicBel102610_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04392.1 .
RefSeqi YP_537481.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RJS2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04392 ; ABE04392 ; RBE_0311 .
GeneIDi 3996285.
KEGGi rbe:RBE_0311.
PATRICi 17881943. VBIRicBel102610_0351.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-317-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiSYL_RICBR
AccessioniPrimary (citable) accession number: Q1RJS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3