Q1RJM0 (COAE_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	RBE_0363

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP-Rule MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP-Rule MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP-Rule MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Dephospho-CoA kinase HAMAP-Rule MF_00376		PRO_0000243332
Regions
	Domain	3 – 191	189	DPCK
	Nucleotide binding	8 – 15	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RJM0 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 0B1FF4C886738782	FASTA	191	22,020
	10 20 30 40 50 60 MLAIGITGSY ASGKTFILDY LAEKGYKTFC ADRCIKELYQ DLKIQTGILK LLPELETFNI 70 80 90 100 110 120 GKISNLIYNN DLAREKLQNF IYPLLIEKLI QFKQENVNSK FGFAEIPLLY EAKFDKYFDF 130 140 150 160 170 180 VVTVHCSEEI RMQRATTRSS FDVEIYNKIK EIQLSQESKI AKADFAINSG VDMLDLEKQI 190 NNLIANLECR V

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04444.1.
RefSeq	YP_537533.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RJM0.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04444; ABE04444; RBE_0363.
GeneID	3995034.
KEGG	rbe:RBE_0363.
PATRIC	17882061. VBIRicBel102610_0410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0237.
HOGENOM	HOG000010652.
KO	K00859.
OMA	CSEEIRM.
ProtClustDB	PRK00081.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-369-MONOMER.
UniPathway	UPA00241; UER00356.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase.
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_RICBR

Accession

Primary (citable) accession number: Q1RJM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program