Q1RJI7 (NUOC_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit C
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit C
NDH-1 subunit C

Gene names

Name:	nuoC
Ordered Locus Names:	RBE_0396

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01357
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01357
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01357.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	NADH-quinone oxidoreductase subunit C HAMAP MF_01357		PRO_0000287857

Sequences

	Sequence		Length	Mass (Da)
	Q1RJI7 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: BB366B45441FD148	FASTA	196	22,945
	10 20 30 40 50 60 MTLEKIIEKL AAKSSILISP ITVKENLAYK VEPNFLLPFL KALKESEELR FTVLTDLFGS 70 80 90 100 110 120 DFPEKAKRFE VVYNLLSLKL NKRLIIKTYV SEHESIPSAM SIFNATCWYE REVYDMFGIN 130 140 150 160 170 180 FDGNDDKRRI LTDYEFEGHP LRKDFPLTGY TQVKYDEQTK KVAYEPVNLD IEYREFDFSS 190 PWHSPTYTLP GDEKAK

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04477.1.
RefSeq	YP_537566.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RJI7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RJI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3996174.
GenomeReviews	Gene locus RBE_0396 in contig CP000087_GR.
KEGG	rbe:RBE_0396.
PATRIC	17882143. VBIRicBel102610_0448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0852.
HOGENOM	HBG727675.
OMA	LTGYTQV.
ProtClustDB	PRK06074.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0396-MONOMER.
Family and domain databases
HAMAP	MF_01357. NDH1_NuoC. [Tree]
InterPro	IPR010218. NADH_DH_suC. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. [Graphical view]
KO	K00332.
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOC_RICBR

Accession

Primary (citable) accession number: Q1RJI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program