ID   NUOA_RICBR              Reviewed;         124 AA.
AC   Q1RJI5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=NADH-quinone oxidoreductase subunit A;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit A;
DE   AltName: Full=NDH-1 subunit A;
DE   AltName: Full=NUO1;
GN   Name=nuoA; OrderedLocusNames=RBE_0398;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be ubiquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits
CC       nuoA, H, J, K, L, M, N constitute the membrane sector of the
CC       complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family.
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DR   EMBL; CP000087; ABE04479.1; -; Genomic_DNA.
DR   RefSeq; YP_537568.1; -.
DR   GeneID; 3996176; -.
DR   GenomeReviews; CP000087_GR; RBE_0398.
DR   KEGG; rbe:RBE_0398; -.
DR   HOGENOM; Q1RJI5; -.
DR   OMA; Q1RJI5; IGFAYEW.
DR   BioCyc; RBEL336407:RBE_0398-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:HAMAP.
DR   GO; GO:0019684; P:photosynthesis, light reaction; IEA:HAMAP.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01394; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   PANTHER; PTHR11058; Oxidored_q4; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD;
KW   Oxidoreductase; Quinone; Transmembrane; Transport; Ubiquinone.
FT   CHAIN         1    124       NADH-quinone oxidoreductase subunit A.
FT                                /FTId=PRO_0000271220.
FT   TRANSMEM     11     31       Potential.
FT   TRANSMEM     68     88       Potential.
FT   TRANSMEM     93    113       Potential.
SQ   SEQUENCE   124 AA;  14415 MW;  F740E3B9971D10CB CRC64;
     MLQNSELLQE YLPIAIFFGI ATLVSSLIMI LPNLLATKKY NKDKLEPYEC GFEPFDDARS
     KFDIRFYLVA ILFIIFDLEI TFLVPWAISL GTIGKIGFFS MMFFLFVLTI GFVYEWKKGA
     LDWE
//