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Q1RJ84

- CLPX_RICBR

UniProt

Q1RJ84 - CLPX_RICBR

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi117 – 1248ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-514-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:RBE_0499
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000277978Add
    BLAST

    Proteomic databases

    PRIDEiQ1RJ84.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0499.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RJ84.
    SMRiQ1RJ84. Positions 8-48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiILLDIMY.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RJ84-1 [UniParc]FASTAAdd to Basket

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    MVVEANKKEL ICSFCSKKQH EVKKLIAGPA VFICDECINL CMDIMEEESK    50
    IALKQITYTI PTPQKICSVL NDYVVGQEQA KKVLAVAVYN HYKRLEYVQS 100
    GNNDVELNKS NILLIGPTGS GKTLLAQTLA KILDVPFTMA DATSLTEAGY 150
    VGEDVENILL RLLQAAEFNV AKAQKGIIYI DEVDKIARKS ENPSITRDVS 200
    GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI LFICGGAFMG 250
    IDSIITSRTN NSSIGFAANV NIDKEKINRE ILKSLEIEDL TKFGLIPEFI 300
    GRLPIVTTLD DLDKEALVTI LTKPKNAIVK QFKKQFELDE AELIVEDSAL 350
    EAIAEKALAK KTGARGLRSI IEHLLLDSMY KVAELKKQRV TITEDVVKGL 400
    IEPIITSIIT PTAKTSKKQA AVEDIPA 427
    Length:427
    Mass (Da):46,882
    Last modified:May 16, 2006 - v1
    Checksum:iD3A44173941705BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04580.1.
    RefSeqiYP_537669.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04580; ABE04580; RBE_0499.
    GeneIDi3994912.
    KEGGirbe:RBE_0499.
    PATRICi17882396. VBIRicBel102610_0569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04580.1 .
    RefSeqi YP_537669.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RJ84.
    SMRi Q1RJ84. Positions 8-48.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0499.

    Proteomic databases

    PRIDEi Q1RJ84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04580 ; ABE04580 ; RBE_0499 .
    GeneIDi 3994912.
    KEGGi rbe:RBE_0499.
    PATRICi 17882396. VBIRicBel102610_0569.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi ILLDIMY.
    OrthoDBi EOG625JZK.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-514-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiCLPX_RICBR
    AccessioniPrimary (citable) accession number: Q1RJ84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3