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Q1RIX7

- GRPE_RICBR

UniProt

Q1RIX7 - GRPE_RICBR

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Protein
Protein GrpE
Gene
grpE, RBE_0606
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding By similarity.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE
Alternative name(s):
HSP-70 cofactor
Gene namesi
Name:grpE
Ordered Locus Names:RBE_0606
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Protein GrpEUniRule annotation
PRO_0000277921Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi336407.RBE_0606.

Structurei

3D structure databases

ProteinModelPortaliQ1RIX7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252083.
KOiK03687.
OMAiHENWEKS.
OrthoDBiEOG6FJNJ9.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RIX7-1 [UniParc]FASTAAdd to Basket

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MTDNNIENKE EEIINDIAEE VENTEIADLK AQIEELKDKL IRASAEIDNT    50
RKRLEKARDE ARDYAITTFA KELLNVSDNL SRALEHKPLD ASVEVTNIIA 100
GVQMTKDELD KVFHKHHIEE IKPEIGSTFD YNLHNAISQI EHPDHEPNSV 150
INIMQVGYRI KDRLLRPATV QVTKKT 176
Length:176
Mass (Da):20,193
Last modified:May 16, 2006 - v1
Checksum:iF42C3C17B3ACBD1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04687.1.
RefSeqiWP_011477275.1. NC_007940.1.
YP_537776.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04687; ABE04687; RBE_0606.
GeneIDi3995951.
KEGGirbe:RBE_0606.
PATRICi17882650. VBIRicBel102610_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04687.1 .
RefSeqi WP_011477275.1. NC_007940.1.
YP_537776.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RIX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0606.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04687 ; ABE04687 ; RBE_0606 .
GeneIDi 3995951.
KEGGi rbe:RBE_0606.
PATRICi 17882650. VBIRicBel102610_0694.

Phylogenomic databases

eggNOGi COG0576.
HOGENOMi HOG000252083.
KOi K03687.
OMAi HENWEKS.
OrthoDBi EOG6FJNJ9.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-623-MONOMER.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
PRINTSi PR00773. GRPEPROTEIN.
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiGRPE_RICBR
AccessioniPrimary (citable) accession number: Q1RIX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi