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Q1RIX7

- GRPE_RICBR

UniProt

Q1RIX7 - GRPE_RICBR

Protein

Protein GrpE

Gene

grpE

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-623-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GrpEUniRule annotation
    Alternative name(s):
    HSP-70 cofactorUniRule annotation
    Gene namesi
    Name:grpEUniRule annotation
    Ordered Locus Names:RBE_0606
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Protein GrpEPRO_0000277921Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RIX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0576.
    HOGENOMiHOG000252083.
    KOiK03687.
    OMAiHENWEKS.
    OrthoDBiEOG6FJNJ9.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    PRINTSiPR00773. GRPEPROTEIN.
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RIX7-1 [UniParc]FASTAAdd to Basket

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    MTDNNIENKE EEIINDIAEE VENTEIADLK AQIEELKDKL IRASAEIDNT    50
    RKRLEKARDE ARDYAITTFA KELLNVSDNL SRALEHKPLD ASVEVTNIIA 100
    GVQMTKDELD KVFHKHHIEE IKPEIGSTFD YNLHNAISQI EHPDHEPNSV 150
    INIMQVGYRI KDRLLRPATV QVTKKT 176
    Length:176
    Mass (Da):20,193
    Last modified:May 16, 2006 - v1
    Checksum:iF42C3C17B3ACBD1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04687.1.
    RefSeqiWP_011477275.1. NC_007940.1.
    YP_537776.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04687; ABE04687; RBE_0606.
    GeneIDi3995951.
    KEGGirbe:RBE_0606.
    PATRICi17882650. VBIRicBel102610_0694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04687.1 .
    RefSeqi WP_011477275.1. NC_007940.1.
    YP_537776.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RIX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04687 ; ABE04687 ; RBE_0606 .
    GeneIDi 3995951.
    KEGGi rbe:RBE_0606.
    PATRICi 17882650. VBIRicBel102610_0694.

    Phylogenomic databases

    eggNOGi COG0576.
    HOGENOMi HOG000252083.
    KOi K03687.
    OMAi HENWEKS.
    OrthoDBi EOG6FJNJ9.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-623-MONOMER.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    PRINTSi PR00773. GRPEPROTEIN.
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiGRPE_RICBR
    AccessioniPrimary (citable) accession number: Q1RIX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3