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Q1RIV2

- HEM1_RICBR

UniProt

Q1RIV2 - HEM1_RICBR

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Protein

5-aminolevulinate synthase

Gene
hemA, RBE_0631
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221Substrate By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Binding sitei185 – 1851Pyridoxal phosphate By similarity
Binding sitei213 – 2131Pyridoxal phosphate By similarity
Binding sitei241 – 2411Pyridoxal phosphate By similarity
Active sitei244 – 2441 By similarity
Binding sitei273 – 2731Pyridoxal phosphate By similarity
Binding sitei274 – 2741Pyridoxal phosphate By similarity
Binding sitei359 – 3591Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-650-MONOMER.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:RBE_0631
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4144145-aminolevulinate synthasePRO_0000280896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441N6-(pyridoxal phosphate)lysine Inferred

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0631.

Structurei

3D structure databases

ProteinModelPortaliQ1RIV2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
KOiK00643.
OMAiHYLQSIN.
OrthoDBiEOG6Q8HZD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RIV2-1 [UniParc]FASTAAdd to Basket

« Hide

MSYYDTIFSD HIDKIKSEGR YREFKALKRQ ADNFPFAMCD DKQIVMWCIN    50
DYLGMSKHPK VVQASIDAVL KYGVGSGGTR NIGGNNVAIL ELEQELASLH 100
NKEASLVFTS GFVANDTTLA TLAKIMPNIV FFSDELNHAS IIAGITGSKA 150
EKHIYRHLDV KHLEELLQSV DINRPKIIVF ESAYSMDGFF SPVKDIINLA 200
KKYNALTFID EVHTVGLYGK TGAGIAELLD CSDEIDIIQG TLAKAYGTIG 250
GYITANHSLI DAIRLSASGF IFTTSLPPVI STAATHSIRH LKESNQERKT 300
HQQVVSKLKS SFDRFNIPYL KNESHIVPII IGDPIKASKA SNMLLNEYSI 350
YVQHINFPTV PRGTERLRII PTPAHTDEMI NDLSIALVQI FAALNIELSS 400
TKELNDEIYL NLIA 414
Length:414
Mass (Da):45,964
Last modified:May 16, 2006 - v1
Checksum:i7D110EE50478F213
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04712.1.
RefSeqiWP_011477300.1. NC_007940.1.
YP_537801.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04712; ABE04712; RBE_0631.
GeneIDi3995921.
KEGGirbe:RBE_0631.
PATRICi17882712. VBIRicBel102610_0723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04712.1 .
RefSeqi WP_011477300.1. NC_007940.1.
YP_537801.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RIV2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04712 ; ABE04712 ; RBE_0631 .
GeneIDi 3995921.
KEGGi rbe:RBE_0631.
PATRICi 17882712. VBIRicBel102610_0723.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
KOi K00643.
OMAi HYLQSIN.
OrthoDBi EOG6Q8HZD.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
BioCyci RBEL336407:GJCY-650-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiHEM1_RICBR
AccessioniPrimary (citable) accession number: Q1RIV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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