Reviewed, UniProtKB/Swiss-Prot Q1RIV2 (HEM1_RICBR)

Names and origin

Protein names

Recommended name:
    5-aminolevulinate synthase
    EC=2.3.1.37
Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-aminolevulinate synthase
    Delta-ALA synthetase

Gene names

Name:	hemA
Ordered Locus Names:	RBE_0631

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Heme biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-aminolevulinate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	5-aminolevulinate synthase		PRO_0000280896
Amino acid modifications
	Modified residue	244	1	N6-(pyridoxal phosphate)lysine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q1RIV2-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 7D110EE50478F213	FASTA	414	45,964
	10 20 30 40 50 60 MSYYDTIFSD HIDKIKSEGR YREFKALKRQ ADNFPFAMCD DKQIVMWCIN DYLGMSKHPK 70 80 90 100 110 120 VVQASIDAVL KYGVGSGGTR NIGGNNVAIL ELEQELASLH NKEASLVFTS GFVANDTTLA 130 140 150 160 170 180 TLAKIMPNIV FFSDELNHAS IIAGITGSKA EKHIYRHLDV KHLEELLQSV DINRPKIIVF 190 200 210 220 230 240 ESAYSMDGFF SPVKDIINLA KKYNALTFID EVHTVGLYGK TGAGIAELLD CSDEIDIIQG 250 260 270 280 290 300 TLAKAYGTIG GYITANHSLI DAIRLSASGF IFTTSLPPVI STAATHSIRH LKESNQERKT 310 320 330 340 350 360 HQQVVSKLKS SFDRFNIPYL KNESHIVPII IGDPIKASKA SNMLLNEYSI YVQHINFPTV 370 380 390 400 410 PRGTERLRII PTPAHTDEMI NDLSIALVQI FAALNIELSS TKELNDEIYL NLIA

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04712.1.
RefSeq	YP_537801.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3995921.
GenomeReviews	Gene locus RBE_0631 in contig CP000087_GR.
KEGG	rbe:RBE_0631.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RIV2.
OMA	Q1RIV2. FSPIKDI.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0631-MON.
Family and domain databases
InterPro	IPR010961. 4pyrrol_synth_NH2levulA_synth. IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01821. 5aminolev_synth. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM1_RICBR

Accession

Primary (citable) accession number: Q1RIV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)