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Q1RIV2

- HEM1_RICBR

UniProt

Q1RIV2 - HEM1_RICBR

Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221SubstrateBy similarity
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei185 – 1851Pyridoxal phosphateBy similarity
    Binding sitei213 – 2131Pyridoxal phosphateBy similarity
    Binding sitei241 – 2411Pyridoxal phosphateBy similarity
    Active sitei244 – 2441By similarity
    Binding sitei273 – 2731Pyridoxal phosphateBy similarity
    Binding sitei274 – 2741Pyridoxal phosphateBy similarity
    Binding sitei359 – 3591SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-650-MONOMER.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hemA
    Ordered Locus Names:RBE_0631
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4144145-aminolevulinate synthasePRO_0000280896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei244 – 2441N6-(pyridoxal phosphate)lysineCurated

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RIV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiHYLQSIN.
    OrthoDBiEOG6Q8HZD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RIV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYYDTIFSD HIDKIKSEGR YREFKALKRQ ADNFPFAMCD DKQIVMWCIN    50
    DYLGMSKHPK VVQASIDAVL KYGVGSGGTR NIGGNNVAIL ELEQELASLH 100
    NKEASLVFTS GFVANDTTLA TLAKIMPNIV FFSDELNHAS IIAGITGSKA 150
    EKHIYRHLDV KHLEELLQSV DINRPKIIVF ESAYSMDGFF SPVKDIINLA 200
    KKYNALTFID EVHTVGLYGK TGAGIAELLD CSDEIDIIQG TLAKAYGTIG 250
    GYITANHSLI DAIRLSASGF IFTTSLPPVI STAATHSIRH LKESNQERKT 300
    HQQVVSKLKS SFDRFNIPYL KNESHIVPII IGDPIKASKA SNMLLNEYSI 350
    YVQHINFPTV PRGTERLRII PTPAHTDEMI NDLSIALVQI FAALNIELSS 400
    TKELNDEIYL NLIA 414
    Length:414
    Mass (Da):45,964
    Last modified:May 16, 2006 - v1
    Checksum:i7D110EE50478F213
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04712.1.
    RefSeqiWP_011477300.1. NC_007940.1.
    YP_537801.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04712; ABE04712; RBE_0631.
    GeneIDi3995921.
    KEGGirbe:RBE_0631.
    PATRICi17882712. VBIRicBel102610_0723.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04712.1 .
    RefSeqi WP_011477300.1. NC_007940.1.
    YP_537801.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RIV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04712 ; ABE04712 ; RBE_0631 .
    GeneIDi 3995921.
    KEGGi rbe:RBE_0631.
    PATRICi 17882712. VBIRicBel102610_0723.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi HYLQSIN.
    OrthoDBi EOG6Q8HZD.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    BioCyci RBEL336407:GJCY-650-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiHEM1_RICBR
    AccessioniPrimary (citable) accession number: Q1RIV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3