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Q1RIS9

- SYFA_RICBR

UniProt

Q1RIS9 - SYFA_RICBR

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Protein
Phenylalanine--tRNA ligase alpha subunit
Gene
pheS, RBE_0654
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:pheS
Ordered Locus Names:RBE_0654
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phenylalanine--tRNA ligase alpha subunitUniRule annotation
PRO_0000278010Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi336407.RBE_0654.

Structurei

3D structure databases

ProteinModelPortaliQ1RIS9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0016.
HOGENOMiHOG000242675.
KOiK01889.
OMAiMGKELNS.
OrthoDBiEOG6WX4QN.

Family and domain databases

HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view]
PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SUPFAMiSSF46589. SSF46589. 1 hit.
TIGRFAMsiTIGR00468. pheS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RIS9-1 [UniParc]FASTAAdd to Basket

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MDNIETILRL AEEKILLVQS LKVLQEYKVE FLGKNGIVTN ELKKLGSLSE    50
QDRKEFGLKI NKLKEEIQNI IKAKEEILEE EELNLKLSSD KIDLSLPARR 100
YKQGSIHPIT QCMEELIQVF AKFGFSIEDG PNIENDFHNF TALNFEDDHP 150
ARQMHDTFYL KGQENDKPML LRTHTSTVQI RAMKNGKPPF RFIAPGRTYR 200
SDSDMTHTPM FHQIEGLVID KDINMGHLKY VITEFIRCFF ENSNIELRFR 250
PSFFPFTEPS AEVDIRMSKT DKWLEVLGCG MVHPNVLKNV GIDNSQYQGF 300
AFGLGVERFA MLKYNIKDLR QFFEGDMRWL KHYSFSSFDI PNLAGGLTK 349
Length:349
Mass (Da):40,516
Last modified:May 16, 2006 - v1
Checksum:iD473EEEE2C2EFFB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04735.1.
RefSeqiWP_011477323.1. NC_007940.1.
YP_537824.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04735; ABE04735; RBE_0654.
GeneIDi3996325.
KEGGirbe:RBE_0654.
PATRICi17882766. VBIRicBel102610_0750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04735.1 .
RefSeqi WP_011477323.1. NC_007940.1.
YP_537824.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RIS9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04735 ; ABE04735 ; RBE_0654 .
GeneIDi 3996325.
KEGGi rbe:RBE_0654.
PATRICi 17882766. VBIRicBel102610_0750.

Phylogenomic databases

eggNOGi COG0016.
HOGENOMi HOG000242675.
KOi K01889.
OMAi MGKELNS.
OrthoDBi EOG6WX4QN.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-673-MONOMER.

Family and domain databases

HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view ]
Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view ]
SUPFAMi SSF46589. SSF46589. 1 hit.
TIGRFAMsi TIGR00468. pheS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiSYFA_RICBR
AccessioniPrimary (citable) accession number: Q1RIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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