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Q1RIN5

- CCME_RICBR

UniProt

Q1RIN5 - CCME_RICBR

Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201Heme (covalent; via pros nitrogen)UniRule annotation
    Metal bindingi124 – 1241Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW
    2. protein-heme linkage Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cytochrome c-type biogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-719-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c-type biogenesis protein CcmEUniRule annotation
    Alternative name(s):
    Cytochrome c maturation protein EUniRule annotation
    Heme chaperone CcmEUniRule annotation
    Gene namesi
    Name:ccmEUniRule annotation
    Synonyms:cycJUniRule annotation
    Ordered Locus Names:RBE_0698
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 137137Cytochrome c-type biogenesis protein CcmEPRO_0000272364Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0698.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RIN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicUniRule annotation
    Topological domaini30 – 137108PeriplasmicUniRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CcmE/CycJ family.UniRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2332.
    HOGENOMiHOG000009661.
    KOiK02197.
    OMAiENYMPRE.
    OrthoDBiEOG69D3JN.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01959. CcmE.
    InterProiIPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF03100. CcmE. 1 hit.
    [Graphical view]
    SUPFAMiSSF82093. SSF82093. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RIN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKGAKNRLI TIIICFCSAV IGVSIILYNL EKSIVFFVPP SKINEVEQGK    50
    ELRVGGLVKV DSINKIAADK ISFVITDNIK DLEIFYQGVL PALFRENQGI 100
    IAIGRLSNGK FIARELLAKH DENYRPPNTV IPAKAGI 137
    Length:137
    Mass (Da):15,124
    Last modified:May 16, 2006 - v1
    Checksum:i5FC0FC3DF53E10AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04779.1.
    RefSeqiYP_537868.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04779; ABE04779; RBE_0698.
    GeneIDi3995409.
    KEGGirbe:RBE_0698.
    PATRICi17882872. VBIRicBel102610_0801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04779.1 .
    RefSeqi YP_537868.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RIN5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04779 ; ABE04779 ; RBE_0698 .
    GeneIDi 3995409.
    KEGGi rbe:RBE_0698.
    PATRICi 17882872. VBIRicBel102610_0801.

    Phylogenomic databases

    eggNOGi COG2332.
    HOGENOMi HOG000009661.
    KOi K02197.
    OMAi ENYMPRE.
    OrthoDBi EOG69D3JN.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-719-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01959. CcmE.
    InterProi IPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF03100. CcmE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82093. SSF82093. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiCCME_RICBR
    AccessioniPrimary (citable) accession number: Q1RIN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3