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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120Heme (covalent; via pros nitrogen)UniRule annotation1
Metal bindingi124Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:RBE_0698
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicUniRule annotation8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd BLAST21
Topological domaini30 – 137PeriplasmicUniRule annotationAdd BLAST108

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002723641 – 137Cytochrome c-type biogenesis protein CcmEAdd BLAST137

Structurei

3D structure databases

ProteinModelPortaliQ1RIN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000009661.
KOiK02197.
OMAiGPDQNVE.
OrthoDBiPOG091H05S8.

Family and domain databases

HAMAPiMF_01959. CcmE. 1 hit.
InterProiIPR004329. CcmE.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RIN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKGAKNRLI TIIICFCSAV IGVSIILYNL EKSIVFFVPP SKINEVEQGK
60 70 80 90 100
ELRVGGLVKV DSINKIAADK ISFVITDNIK DLEIFYQGVL PALFRENQGI
110 120 130
IAIGRLSNGK FIARELLAKH DENYRPPNTV IPAKAGI
Length:137
Mass (Da):15,124
Last modified:May 16, 2006 - v1
Checksum:i5FC0FC3DF53E10AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04779.1.
RefSeqiWP_011477366.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04779; ABE04779; RBE_0698.
KEGGirbe:RBE_0698.
PATRICi17882872. VBIRicBel102610_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04779.1.
RefSeqiWP_011477366.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RIN5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE04779; ABE04779; RBE_0698.
KEGGirbe:RBE_0698.
PATRICi17882872. VBIRicBel102610_0801.

Phylogenomic databases

HOGENOMiHOG000009661.
KOiK02197.
OMAiGPDQNVE.
OrthoDBiPOG091H05S8.

Family and domain databases

HAMAPiMF_01959. CcmE. 1 hit.
InterProiIPR004329. CcmE.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCME_RICBR
AccessioniPrimary (citable) accession number: Q1RIN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.