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Q1RIN5

- CCME_RICBR

UniProt

Q1RIN5 - CCME_RICBR

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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Heme (covalent; via pros nitrogen)UniRule annotation
Metal bindingi124 – 1241Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
  2. protein-heme linkage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-719-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:RBE_0698
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Cytochrome c-type biogenesis protein CcmEPRO_0000272364Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0698.

Structurei

3D structure databases

ProteinModelPortaliQ1RIN5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicUniRule annotation
Topological domaini30 – 137108PeriplasmicUniRule annotationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2332.
HOGENOMiHOG000009661.
KOiK02197.
OMAiENYMPRE.
OrthoDBiEOG69D3JN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RIN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKGAKNRLI TIIICFCSAV IGVSIILYNL EKSIVFFVPP SKINEVEQGK
60 70 80 90 100
ELRVGGLVKV DSINKIAADK ISFVITDNIK DLEIFYQGVL PALFRENQGI
110 120 130
IAIGRLSNGK FIARELLAKH DENYRPPNTV IPAKAGI
Length:137
Mass (Da):15,124
Last modified:May 16, 2006 - v1
Checksum:i5FC0FC3DF53E10AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04779.1.
RefSeqiYP_537868.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04779; ABE04779; RBE_0698.
GeneIDi3995409.
KEGGirbe:RBE_0698.
PATRICi17882872. VBIRicBel102610_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04779.1 .
RefSeqi YP_537868.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RIN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04779 ; ABE04779 ; RBE_0698 .
GeneIDi 3995409.
KEGGi rbe:RBE_0698.
PATRICi 17882872. VBIRicBel102610_0801.

Phylogenomic databases

eggNOGi COG2332.
HOGENOMi HOG000009661.
KOi K02197.
OMAi ENYMPRE.
OrthoDBi EOG69D3JN.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-719-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_01959. CcmE.
InterProi IPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF03100. CcmE. 1 hit.
[Graphical view ]
SUPFAMi SSF82093. SSF82093. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiCCME_RICBR
AccessioniPrimary (citable) accession number: Q1RIN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3