Q1RIN5 (CCME_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c-type biogenesis protein CcmE

Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE

Gene names

Name:	ccmE
Synonyms:	cycJ
Ordered Locus Names:	RBE_0698

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP-Rule MF_01959
Subcellular location	Cell inner membrane; Single-pass type II membrane protein; Periplasmic side Potential HAMAP-Rule MF_01959.
Sequence similarities	Belongs to the CcmE/CycJ family.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW protein-heme linkage Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959		PRO_0000272364
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 29	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	30 – 137	108	Periplasmic Potential
Sites
	Metal binding	124	1	Iron (heme axial ligand) By similarity
	Binding site	120	1	Heme (covalent; via pros nitrogen) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RIN5 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 5FC0FC3DF53E10AD	FASTA	137	15,124
	10 20 30 40 50 60 MQKGAKNRLI TIIICFCSAV IGVSIILYNL EKSIVFFVPP SKINEVEQGK ELRVGGLVKV 70 80 90 100 110 120 DSINKIAADK ISFVITDNIK DLEIFYQGVL PALFRENQGI IAIGRLSNGK FIARELLAKH 130 DENYRPPNTV IPAKAGI

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04779.1.
RefSeq	YP_537868.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RIN5.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0698.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04779; ABE04779; RBE_0698.
GeneID	3995409.
KEGG	rbe:RBE_0698.
PATRIC	17882872. VBIRicBel102610_0801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2332.
HOGENOM	HOG000009661.
KO	K02197.
OMA	ICFCSAC.
ProtClustDB	PRK13254.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-719-MONOMER.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_01959. CcmE.
InterPro	IPR004329. CcmE. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF03100. CcmE. 1 hit. [Graphical view]
SUPFAM	SSF82093. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CCME_RICBR

Accession

Primary (citable) accession number: Q1RIN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program