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Q1RIN5 (CCME_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene names
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:RBE_0698
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP-Rule MF_01959

Subcellular location

Cell inner membrane; Single-pass type II membrane protein; Periplasmic side Potential HAMAP-Rule MF_01959.

Sequence similarities

Belongs to the CcmE/CycJ family.

Ontologies

Keywords
   Biological processCytochrome c-type biogenesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   LigandHeme
Iron
Metal-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcytochrome complex assembly

Inferred from electronic annotation. Source: UniProtKB-KW

protein-heme linkage

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959
PRO_0000272364

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain30 – 137108Periplasmic Potential

Sites

Metal binding1241Iron (heme axial ligand) By similarity
Binding site1201Heme (covalent; via pros nitrogen) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RIN5 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 5FC0FC3DF53E10AD

FASTA13715,124
        10         20         30         40         50         60 
MQKGAKNRLI TIIICFCSAV IGVSIILYNL EKSIVFFVPP SKINEVEQGK ELRVGGLVKV 

        70         80         90        100        110        120 
DSINKIAADK ISFVITDNIK DLEIFYQGVL PALFRENQGI IAIGRLSNGK FIARELLAKH 

       130 
DENYRPPNTV IPAKAGI 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04779.1.
RefSeqYP_537868.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RIN5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0698.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04779; ABE04779; RBE_0698.
GeneID3995409.
KEGGrbe:RBE_0698.
PATRIC17882872. VBIRicBel102610_0801.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2332.
HOGENOMHOG000009661.
KOK02197.
OMAGPDQNVE.
OrthoDBEOG69D3JN.
ProtClustDBPRK13254.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-719-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_01959. CcmE.
InterProIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMSSF82093. SSF82093. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCCME_RICBR
AccessionPrimary (citable) accession number: Q1RIN5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names