Reviewed,
UniProtKB/Swiss-Prot Q1RIM1 (TOP1_RICBR)
Last modified
June 16, 2009.
Version 22.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA topoisomerase 1 EC=5.99.1.2 Alternative name(s): DNA topoisomerase I Omega-protein Relaxing enzyme Untwisting enzyme Swivelase | ||||
| Gene names |
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| Organism | Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 336407 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia |
Protein attributes
| Sequence length | 800 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. |
| Catalytic activity | ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. |
| Subunit structure | Monomer By similarity. |
| Miscellaneous | When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand. |
| Sequence similarities | Belongs to the prokaryotic type I/III topoisomerase family. |
Ontologies
| Keywords | |
|---|---|
| Domain | Zinc-finger |
| Ligand | ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc |
| Molecular function | Isomerase Topoisomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA topological change Inferred from electronic annotation. Source: InterPro DNA unwinding during replicationInferred from electronic annotation. Source: InterPro |
| Cellular component | chromosome Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase type I activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000087 Genomic DNA. Translation: ABE04793.1. | |
| RefSeq | YP_537882.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3995312. |
| GenomeReviews | Gene locus RBE_0712 in contig CP000087_GR. |
| KEGG | rbe:RBE_0712. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q1RIM1. |
| OMA | Q1RIM1. TGQVVKF. |
Enzyme and pathway databases | |
| BioCyc | RBEL336407:RBE_0712-MON. |
Family and domain databases | |
| InterPro | IPR003601. Topo_IA_2. IPR013497. Topo_IA_cen. IPR013824. Topo_IA_cen_sub1. IPR013826. Topo_IA_cen_sub3. IPR000380. Topo_IA_core. IPR003602. Topo_IA_DNA_bd. IPR013498. Topo_IA_Znf. IPR005733. TopoI_bac. IPR006171. Toprim_domain. IPR006154. Toprim_sub. [Graphical view] |
| Gene3D | G3DSA:1.10.460.10. Topo_IA_cen_sub1. 1 hit. G3DSA:1.10.290.10. Topo_IA_cen_sub3. 1 hit. |
| PANTHER | PTHR11390. Topo_IA. 1 hit. |
| Pfam | PF01131. Topoisom_bac. 1 hit. PF01751. Toprim. 1 hit. PF01396. zf-C4_Topoisom. 1 hit. [Graphical view] |
| PRINTS | PR00417. PRTPISMRASEI. |
| SMART | SM00437. TOP1Ac. 1 hit. SM00436. TOP1Bc. 1 hit. SM00493. TOPRIM. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01051. topA_bact. 1 hit. |
| PROSITE | PS00396. TOPOISOMERASE_I_PROK. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TOP1_RICBR | ||||||||
| Accession | Primary (citable) accession number: Q1RIM1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Rickettsia bellii strain RML369-C Rickettsia bellii (strain RML369-C): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


