ID   CDSA_RICBR              Reviewed;         231 AA.
AC   Q1RII7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Phosphatidate cytidylyltransferase;
DE            EC=2.7.7.41;
DE   AltName: Full=CDP-diglyceride pyrophosphorylase;
DE   AltName: Full=CDP-diglyceride synthetase;
DE   AltName: Full=CDP-diacylglycerol synthase;
DE            Short=CDS;
DE   AltName: Full=CTP:phosphatidate cytidylyltransferase;
DE   AltName: Full=CDP-DG synthetase;
DE   AltName: Full=CDP-DAG synthase;
GN   Name=cdsA; OrderedLocusNames=RBE_0746;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- CATALYTIC ACTIVITY: CTP + phosphatidate = diphosphate + CDP-
CC       diacylglycerol.
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis;
CC       CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the CDS family.
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DR   EMBL; CP000087; ABE04827.1; -; Genomic_DNA.
DR   RefSeq; YP_537916.1; -.
DR   GeneID; 3995428; -.
DR   GenomeReviews; CP000087_GR; RBE_0746.
DR   KEGG; rbe:RBE_0746; -.
DR   HOGENOM; Q1RII7; -.
DR   OMA; Q1RII7; CTIFGSI.
DR   BioCyc; RBEL336407:RBE_0746-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; IEA:EC.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000374; PC_trans.
DR   Pfam; PF01148; CTP_transf_1; 1.
DR   PROSITE; PS01315; CDS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Membrane; Nucleotidyltransferase;
KW   Phospholipid biosynthesis; Transferase; Transmembrane.
FT   CHAIN         1    231       Phosphatidate cytidylyltransferase.
FT                                /FTId=PRO_0000281056.
FT   TRANSMEM     33     53       Potential.
FT   TRANSMEM     67     87       Potential.
FT   TRANSMEM     95    115       Potential.
FT   TRANSMEM    133    153       Potential.
FT   TRANSMEM    167    187       Potential.
FT   TRANSMEM    206    226       Potential.
SQ   SEQUENCE   231 AA;  25953 MW;  271C1A453FA649F2 CRC64;
     MIIQKGKEHL AKDKQKSNLY LRILSGIVLV PSFVVAILWL KPLFYVLMIL VAIGMLSEWY
     DMTHSSIMYL LIGLIIIPIP ISLLIFLSSN PINNWLIMLY FCIVWSVDIF AMIGGKTLGG
     AKLAPKISPK KTWSGLITGI LSAGLVATLI SFIPSFYIEN YYFSNRIYLF IISCTLALTA
     QLSDLFISYF KRKFNIKDSG NIIPGHGGVL DRFDSIILTA PILFFINGLY L
//