Reviewed, UniProtKB/Swiss-Prot Q1RII7 (CDSA_RICBR)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	RBE_0746

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Phosphatidate cytidylyltransferase		PRO_0000281056
Regions
	Transmembrane	33 – 53	21	Potential
	Transmembrane	67 – 87	21	Potential
	Transmembrane	95 – 115	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	167 – 187	21	Potential
	Transmembrane	206 – 226	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RII7-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 271C1A453FA649F2	FASTA	231	25,953
	10 20 30 40 50 60 MIIQKGKEHL AKDKQKSNLY LRILSGIVLV PSFVVAILWL KPLFYVLMIL VAIGMLSEWY 70 80 90 100 110 120 DMTHSSIMYL LIGLIIIPIP ISLLIFLSSN PINNWLIMLY FCIVWSVDIF AMIGGKTLGG 130 140 150 160 170 180 AKLAPKISPK KTWSGLITGI LSAGLVATLI SFIPSFYIEN YYFSNRIYLF IISCTLALTA 190 200 210 220 230 QLSDLFISYF KRKFNIKDSG NIIPGHGGVL DRFDSIILTA PILFFINGLY L

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04827.1.
RefSeq	YP_537916.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RII7.
Genome annotation databases
GeneID	3995428.
GenomeReviews	Gene locus RBE_0746 in contig CP000087_GR.
KEGG	rbe:RBE_0746.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RII7.
OMA	CTIFGSI.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0746-MON.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_RICBR

Accession

Primary (citable) accession number: Q1RII7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)