Q1RID9 (GYRA_RICBR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA gyrase subunit A EC=5.99.1.3 | ||||
| Gene names |
| ||||
| Organism | Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 336407 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia |
Protein attributes
| Sequence length | 905 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897 |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897 |
| Subunit structure | Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. |
| Subcellular location | Cytoplasm Potential HAMAP MF_01897. |
| Sequence similarities | Belongs to the topoisomerase GyrA/ParC subunit family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Isomerase Topoisomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA topological change Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependentInferred from electronic annotation. Source: InterPro |
| Cellular component | chromosome Inferred from electronic annotation. Source: InterPro cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 905 | 905 | DNA gyrase subunit A HAMAP MF_01897 | PRO_0000273107 | |||||
Sites | |||||||||
| Active site | 123 | 1 | O-(5'-phospho-DNA)-tyrosine intermediate By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000087 Genomic DNA. Translation: ABE04875.1. |
| RefSeq | YP_537964.1. NC_007940.1. |
3D structure databases | |
| ProteinModelPortal | Q1RID9. |
| SMR | Q1RID9. Positions 31-512. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q1RID9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3995617. |
| GenomeReviews | Gene locus RBE_0794 in contig CP000087_GR. |
| KEGG | rbe:RBE_0794. |
| PATRIC | 17883087. VBIRicBel102610_0907. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0188. |
| HOGENOM | HBG635183. |
| OMA | TGRGRIY. |
| ProtClustDB | PRK05560. |
Enzyme and pathway databases | |
| BioCyc | RBEL336407:RBE_0794-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01897. GyrA. [Tree] |
| InterPro | IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view] |
| Gene3D | G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit. |
| KO | K02469. |
| Pfam | PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view] |
| SMART | SM00434. TOP4c. 1 hit. [Graphical view] |
| SUPFAM | SSF56719. Topo_IIA_cen. 1 hit. |
| TIGRFAMs | TIGR01063. GyrA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GYRA_RICBR | ||||||||
| Accession | Primary (citable) accession number: Q1RID9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Rickettsia bellii strain RML369-C Rickettsia bellii (strain RML369-C): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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