Reviewed, UniProtKB/Swiss-Prot Q1RID6 (LON_RICBR)

Names and origin

Protein names

Recommended name:
    ATP-dependent protease La
    EC=3.4.21.53

Gene names

Name:	lon
Ordered Locus Names:	RBE_0797

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	775 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Degrades short-lived regulatory and abnormal proteins in presence of ATP. Hydrolyzes two ATPs for each peptide bond cleaved in the protein substrate By similarity.
Catalytic activity	Hydrolysis of proteins in presence of ATP.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S16 family. Contains 1 Lon domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 775	775	ATP-dependent protease La		PRO_0000280891
Regions
	Domain	5 – 205	201	Lon
	Nucleotide binding	356 – 363	8	ATP Potential
Sites
	Active site	679	1	By similarity
	Active site	722	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RID6-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 5F0AB73EE9EA39A8	FASTA	775	86,722
	10 20 30 40 50 60 MNKKSLPLMA LRDIVVFPGV IAPVFVGRQK SLHALSNTTL SEEDNSKYIL VTLQKKFDQE 70 80 90 100 110 120 NPNRNELYDV GILAKVIQIV KLPNTTAKIL VEAIARVKIS NIKGDEAFEA NYEIIPDEEI 130 140 150 160 170 180 FDANNMRSLV DNAVQLFAKY AGSDKKINAE IIETINKEIS ETSNFINIIN ILASHLITSL 190 200 210 220 230 240 EEKQRLLEET SPFKRISTII NILTSNIVNS ETEQALQQRV KKQIEKTQRD YYLHEQMKAI 250 260 270 280 290 300 QKELDEDKSD LAEFDKKIKA AKLSKEAREK AEAELKKLRT MNQMSAESGV TRNYLETLLS 310 320 330 340 350 360 LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSSKIRGP ILCLIGPPGV 370 380 390 400 410 420 GKTSLIKSIA EGMGRKYTKF ALGGVRDEAE IRGHRKTYLG SMPGKILTQL KKVKTSNPVM 430 440 450 460 470 480 LLDEIDKMGS DFRGDPASAL LEVLDPEQNS HFVDHYLEVE YDLSNVIFIA TANSYNLPRA 490 500 510 520 530 540 LIDRMEIIDI SGYMEEEKIQ IAKNYLVPKQ LKMHKIKKDE ITISDDAILD LIRYYTKESG 550 560 570 580 590 600 VRSLEREIGA LTRKALKQIL ADKKVKHISV DSNNLEEFLG ARKYNFGLAE KNDQIGSTTG 610 620 630 640 650 660 LAYTEVGGEL LTIEALSFPG KGEIKTTGKL GDVMKESAMA AYSCFRSRAA DFGLKYEDYK 670 680 690 700 710 720 DFDVHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVRRT VAMTGEVTLR GNVLPIGGLK 730 740 750 760 770 EKLLAASRGG IKTVLIPEEN VKDLKDIPPN IKSSLEIIPV SNIDQVLEHA LTKKT

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04878.1.
RefSeq	YP_537967.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S16.001.
Genome annotation databases
GeneID	3995620.
GenomeReviews	Gene locus RBE_0797 in contig CP000087_GR.
KEGG	rbe:RBE_0797.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RID6.
OMA	Q1RID6. VMKESIQ.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0797-MON.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR001984. Peptidase_S16_C. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view]
PRINTS	PR00830. ENDOLAPTASE.
SMART	SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view]
TIGRFAMs	TIGR00763. lon. 1 hit.
PROSITE	PS01046. LON_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LON_RICBR

Accession

Primary (citable) accession number: Q1RID6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)