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Q1RID6

- LON_RICBR

UniProt

Q1RID6 - LON_RICBR

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Protein

Lon protease

Gene
lon, RBE_0797
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei679 – 6791 By similarity
Active sitei722 – 7221 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi356 – 3638ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATP-dependent peptidase activity Source: UniProtKB-HAMAP
  3. sequence-specific DNA binding Source: UniProtKB-HAMAP
  4. serine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular response to stress Source: UniProtKB-HAMAP
  2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-819-MONOMER.

Protein family/group databases

MEROPSiS16.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease (EC:3.4.21.53)
Alternative name(s):
ATP-dependent protease La
Gene namesi
Name:lon
Ordered Locus Names:RBE_0797
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Lon proteaseUniRule annotationPRO_0000280891Add
BLAST

Expressioni

Inductioni

By heat shock By similarity.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity By similarity.

Protein-protein interaction databases

STRINGi336407.RBE_0797.

Structurei

3D structure databases

ProteinModelPortaliQ1RID6.
SMRiQ1RID6. Positions 491-584, 594-774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 204199LonAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.
Contains 1 Lon domain.

Phylogenomic databases

eggNOGiCOG0466.
HOGENOMiHOG000261410.
KOiK01338.
OMAiNATGRKY.
OrthoDBiEOG6XHC23.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RID6-1 [UniParc]FASTAAdd to Basket

« Hide

MNKKSLPLMA LRDIVVFPGV IAPVFVGRQK SLHALSNTTL SEEDNSKYIL    50
VTLQKKFDQE NPNRNELYDV GILAKVIQIV KLPNTTAKIL VEAIARVKIS 100
NIKGDEAFEA NYEIIPDEEI FDANNMRSLV DNAVQLFAKY AGSDKKINAE 150
IIETINKEIS ETSNFINIIN ILASHLITSL EEKQRLLEET SPFKRISTII 200
NILTSNIVNS ETEQALQQRV KKQIEKTQRD YYLHEQMKAI QKELDEDKSD 250
LAEFDKKIKA AKLSKEAREK AEAELKKLRT MNQMSAESGV TRNYLETLLS 300
LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSSKIRGP 350
ILCLIGPPGV GKTSLIKSIA EGMGRKYTKF ALGGVRDEAE IRGHRKTYLG 400
SMPGKILTQL KKVKTSNPVM LLDEIDKMGS DFRGDPASAL LEVLDPEQNS 450
HFVDHYLEVE YDLSNVIFIA TANSYNLPRA LIDRMEIIDI SGYMEEEKIQ 500
IAKNYLVPKQ LKMHKIKKDE ITISDDAILD LIRYYTKESG VRSLEREIGA 550
LTRKALKQIL ADKKVKHISV DSNNLEEFLG ARKYNFGLAE KNDQIGSTTG 600
LAYTEVGGEL LTIEALSFPG KGEIKTTGKL GDVMKESAMA AYSCFRSRAA 650
DFGLKYEDYK DFDVHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVRRT 700
VAMTGEVTLR GNVLPIGGLK EKLLAASRGG IKTVLIPEEN VKDLKDIPPN 750
IKSSLEIIPV SNIDQVLEHA LTKKT 775
Length:775
Mass (Da):86,722
Last modified:May 16, 2006 - v1
Checksum:i5F0AB73EE9EA39A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04878.1.
RefSeqiYP_537967.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04878; ABE04878; RBE_0797.
GeneIDi3995620.
KEGGirbe:RBE_0797.
PATRICi17883093. VBIRicBel102610_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04878.1 .
RefSeqi YP_537967.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RID6.
SMRi Q1RID6. Positions 491-584, 594-774.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0797.

Protein family/group databases

MEROPSi S16.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04878 ; ABE04878 ; RBE_0797 .
GeneIDi 3995620.
KEGGi rbe:RBE_0797.
PATRICi 17883093. VBIRicBel102610_0910.

Phylogenomic databases

eggNOGi COG0466.
HOGENOMi HOG000261410.
KOi K01338.
OMAi NATGRKY.
OrthoDBi EOG6XHC23.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-819-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01973. lon_bact.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR10046. PTHR10046. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001174. Lon_proteas. 1 hit.
SMARTi SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR00763. lon. 1 hit.
PROSITEi PS01046. LON_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiLON_RICBR
AccessioniPrimary (citable) accession number: Q1RID6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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