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Protein

Lon protease

Gene

lon

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei679 – 6791UniRule annotation
Active sitei722 – 7221UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi356 – 3638ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-819-MONOMER.

Protein family/group databases

MEROPSiS16.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:RBE_0797
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Lon proteasePRO_0000280891Add
BLAST

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RID6.
SMRiQ1RID6. Positions 491-584, 594-774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 204199LonUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0466.
HOGENOMiHOG000261410.
KOiK01338.
OMAiVYIRIED.
OrthoDBiEOG6XHC23.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RID6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKSLPLMA LRDIVVFPGV IAPVFVGRQK SLHALSNTTL SEEDNSKYIL
60 70 80 90 100
VTLQKKFDQE NPNRNELYDV GILAKVIQIV KLPNTTAKIL VEAIARVKIS
110 120 130 140 150
NIKGDEAFEA NYEIIPDEEI FDANNMRSLV DNAVQLFAKY AGSDKKINAE
160 170 180 190 200
IIETINKEIS ETSNFINIIN ILASHLITSL EEKQRLLEET SPFKRISTII
210 220 230 240 250
NILTSNIVNS ETEQALQQRV KKQIEKTQRD YYLHEQMKAI QKELDEDKSD
260 270 280 290 300
LAEFDKKIKA AKLSKEAREK AEAELKKLRT MNQMSAESGV TRNYLETLLS
310 320 330 340 350
LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSSKIRGP
360 370 380 390 400
ILCLIGPPGV GKTSLIKSIA EGMGRKYTKF ALGGVRDEAE IRGHRKTYLG
410 420 430 440 450
SMPGKILTQL KKVKTSNPVM LLDEIDKMGS DFRGDPASAL LEVLDPEQNS
460 470 480 490 500
HFVDHYLEVE YDLSNVIFIA TANSYNLPRA LIDRMEIIDI SGYMEEEKIQ
510 520 530 540 550
IAKNYLVPKQ LKMHKIKKDE ITISDDAILD LIRYYTKESG VRSLEREIGA
560 570 580 590 600
LTRKALKQIL ADKKVKHISV DSNNLEEFLG ARKYNFGLAE KNDQIGSTTG
610 620 630 640 650
LAYTEVGGEL LTIEALSFPG KGEIKTTGKL GDVMKESAMA AYSCFRSRAA
660 670 680 690 700
DFGLKYEDYK DFDVHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVRRT
710 720 730 740 750
VAMTGEVTLR GNVLPIGGLK EKLLAASRGG IKTVLIPEEN VKDLKDIPPN
760 770
IKSSLEIIPV SNIDQVLEHA LTKKT
Length:775
Mass (Da):86,722
Last modified:May 16, 2006 - v1
Checksum:i5F0AB73EE9EA39A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04878.1.
RefSeqiWP_011477465.1. NC_007940.1.
YP_537967.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04878; ABE04878; RBE_0797.
KEGGirbe:RBE_0797.
PATRICi17883093. VBIRicBel102610_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04878.1.
RefSeqiWP_011477465.1. NC_007940.1.
YP_537967.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RID6.
SMRiQ1RID6. Positions 491-584, 594-774.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS16.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE04878; ABE04878; RBE_0797.
KEGGirbe:RBE_0797.
PATRICi17883093. VBIRicBel102610_0910.

Phylogenomic databases

eggNOGiCOG0466.
HOGENOMiHOG000261410.
KOiK01338.
OMAiVYIRIED.
OrthoDBiEOG6XHC23.

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-819-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiLON_RICBR
AccessioniPrimary (citable) accession number: Q1RID6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.