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Q1RIC9

- SYP_RICBR

UniProt

Q1RIC9 - SYP_RICBR

Protein

Proline--tRNA ligase

Gene

proS

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

    Catalytic activityi

    ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. proline-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prolyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-826-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
    Alternative name(s):
    Prolyl-tRNA synthetaseUniRule annotation
    Short name:
    ProRSUniRule annotation
    Gene namesi
    Name:proSUniRule annotation
    Ordered Locus Names:RBE_0804
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Proline--tRNA ligasePRO_0000248914Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RIC9.
    SMRiQ1RIC9. Positions 1-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0442.
    HOGENOMiHOG000076894.
    KOiK01881.
    OMAiCDTIEKL.
    OrthoDBiEOG6TTVMR.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_01570. Pro_tRNA_synth_type2.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004500. Pro-tRNA-synth_IIa_bac-type.
    IPR023716. Prolyl-tRNA_ligase_IIa_type2.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PRINTSiPR01046. TRNASYNTHPRO.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00409. proS_fam_II. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RIC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLSKYFLPV LKEDPSEAQI TSHKLMLRSG MIRQQAAGIY SWLPLGLKVL    50
    KNIENIVRSN MDKAGCLEVL MPCIQPAHLW VESGRFDNYG KEMLKFQDRH 100
    DNTLLFGPTN EDMVTDIFRN NIKSYKDLPK NLYHIQWKFR DEIRPRFGVM 150
    RGREFLMKDA YSFDIDEESA VKTYNQMYKA YINTFRDLGV FAVPVIADNG 200
    PIGGKLSHEF HIIAETGESN IYYDKRFKTL KDNPDIDIEE IKSWYAAAEE 250
    KHDASKLSSD KEITSSKGIE VGHIFYIGTK YSVNMNALIN DEHGKLTPIE 300
    MSSYGIGISR LVAAIIEANS DAKGIIWPIA VAPFKISLIN LNIHDSKCLE 350
    LAERVYNELL AQNIEVLYDD TDVRAGSKFA THDLIGSPYQ IIIGPKKAAN 400
    NIVELKNRKN GEIEDIDLNK RALNSYLTFF NS 432
    Length:432
    Mass (Da):49,206
    Last modified:May 16, 2006 - v1
    Checksum:iF86E21AA57A6B3FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04885.1.
    RefSeqiYP_537974.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04885; ABE04885; RBE_0804.
    GeneIDi3996267.
    KEGGirbe:RBE_0804.
    PATRICi17883107. VBIRicBel102610_0917.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04885.1 .
    RefSeqi YP_537974.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RIC9.
    SMRi Q1RIC9. Positions 1-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04885 ; ABE04885 ; RBE_0804 .
    GeneIDi 3996267.
    KEGGi rbe:RBE_0804.
    PATRICi 17883107. VBIRicBel102610_0917.

    Phylogenomic databases

    eggNOGi COG0442.
    HOGENOMi HOG000076894.
    KOi K01881.
    OMAi CDTIEKL.
    OrthoDBi EOG6TTVMR.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-826-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_01570. Pro_tRNA_synth_type2.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004500. Pro-tRNA-synth_IIa_bac-type.
    IPR023716. Prolyl-tRNA_ligase_IIa_type2.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PRINTSi PR01046. TRNASYNTHPRO.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00409. proS_fam_II. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiSYP_RICBR
    AccessioniPrimary (citable) accession number: Q1RIC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3