Q1RIC1 (LPXB_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	RBE_0812

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255217

Sequences

	Sequence		Length	Mass (Da)
	Q1RIC1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: D0638A415D4C40DE	FASTA	381	43,782
	10 20 30 40 50 60 MKKIYFIAGE ASGDFAGGRI IRNLKADKEL KIIGIGGRNM EEAGNFESLF PISEINLMGF 70 80 90 100 110 120 FEVIPHIFRI KKLINKTVED IIDNKPDILI TIDSPGFTYR VAAKVRERLP ELKMIHIVAP 130 140 150 160 170 180 SVWAYKEGRA AKYAKIYNCL FALLPFEPPY FTKVGLDCRY IGHPIMEQEF YSDKVALRQE 190 200 210 220 230 240 LEIDEDTKVL CVTLGSRKGE ILRHLPIFIP AIEKVYDDHK KKLMVIFPLA NPDHERIIKP 250 260 270 280 290 300 FLEKVRFNYI FSYERLKSYA VSDLALAKSG TNTLEIAASG TPMIVAYKVN IFSFIIIRLL 310 320 330 340 350 360 IKIKYVTLIN IIGNREIIPE FIQFNCEANL ISDKLKELLL NPQEVDKQIT ESHKILQELG 370 380 FKSNIYPSYL ATKIIRQEFL K

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04893.1.
RefSeq	YP_537982.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RIC1.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0812.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04893; ABE04893; RBE_0812.
GeneID	3996275.
KEGG	rbe:RBE_0812.
PATRIC	17883125. VBIRicBel102610_0926.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	PRK00025.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-834-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_RICBR

Accession

Primary (citable) accession number: Q1RIC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program