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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei263ATPUniRule annotation1
Binding sitei330ATPUniRule annotation1
Binding sitei402ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 78ATPUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:G1G4P-1165-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:RBE_0816
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002779801 – 452ATP-dependent protease ATPase subunit HslUAdd BLAST452

Proteomic databases

PRIDEiQ1RIB7

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RIB7
SMRiQ1RIB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000010036
KOiK03667
OMAiKYGMIKT
OrthoDBiPOG091H01U4

Family and domain databases

HAMAPiMF_00249 HslU, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004491 HslU
IPR027417 P-loop_NTPase
PANTHERiPTHR43815 PTHR43815, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00390 hslU, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RIB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTKTTNTN KKDPMGLTPS QIVNELNRFI VGQEKAKKAV AIALRNRGRR
60 70 80 90 100
KRVEGNLRNE IVPKNILMIG STGVGKTEIA RRLAKLTNSP FYKIEATKFT
110 120 130 140 150
EVGYVGRDVE SIIRDLVEIA VNTQKTIAKT EVDINAREKA IERVLESLVG
160 170 180 190 200
KTSSSKTREK FQEKILSGEL DDTEIEISVA DTAPVGGGSF EIPGMPGASM
210 220 230 240 250
GVLNLGDMIG RAFGTTKTKT KKMLVKEAMS IILSEESEKL IDQEKIIQQA
260 270 280 290 300
INLVENDGIV FIDEIDKIAS VANSGAKNSE ISREGVQKDL LPLIEGTTVN
310 320 330 340 350
TKYGPVKTDH ILFIASGAFH IAKPSDLLPE LQGRLPIRVE LNSLTKEDMI
360 370 380 390 400
KILLEPETSL IKQYSALIGT EKVELEFTNS AIEKIADYAT TVNLEIEDIG
410 420 430 440 450
ARRLHTILEN LLEDISFRAS EMQGEKISID DKFVENQLSK ILTNLDLAKF

VL
Length:452
Mass (Da):49,865
Last modified:May 16, 2006 - v1
Checksum:i59DE8AA2EDCA649D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA Translation: ABE04897.1
RefSeqiWP_011477484.1, NC_007940.1

Genome annotation databases

EnsemblBacteriaiABE04897; ABE04897; RBE_0816
KEGGirbe:RBE_0816

Similar proteinsi

Entry informationi

Entry nameiHSLU_RICBR
AccessioniPrimary (citable) accession number: Q1RIB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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