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Q1RIB7

- HSLU_RICBR

UniProt

Q1RIB7 - HSLU_RICBR

Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei263 – 2631ATPUniRule annotation
    Binding sitei330 – 3301ATPUniRule annotation
    Binding sitei402 – 4021ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 786ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP
    3. peptidase activity, acting on L-amino acid peptides Source: InterPro

    GO - Biological processi

    1. protein unfolding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-838-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent protease ATPase subunit HslUUniRule annotation
    Alternative name(s):
    Unfoldase HslUUniRule annotation
    Gene namesi
    Name:hslUUniRule annotation
    Ordered Locus Names:RBE_0816
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. HslUV protease complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452ATP-dependent protease ATPase subunit HslUPRO_0000277980Add
    BLAST

    Interactioni

    Subunit structurei

    A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0816.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RIB7.
    SMRiQ1RIB7. Positions 17-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1220.
    HOGENOMiHOG000010036.
    KOiK03667.
    OMAiPVGVEIM.
    OrthoDBiEOG6NPM7G.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00249. HslU.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004491. HslU.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11262:SF3. PTHR11262:SF3. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00390. hslU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RIB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSTKTTNTN KKDPMGLTPS QIVNELNRFI VGQEKAKKAV AIALRNRGRR    50
    KRVEGNLRNE IVPKNILMIG STGVGKTEIA RRLAKLTNSP FYKIEATKFT 100
    EVGYVGRDVE SIIRDLVEIA VNTQKTIAKT EVDINAREKA IERVLESLVG 150
    KTSSSKTREK FQEKILSGEL DDTEIEISVA DTAPVGGGSF EIPGMPGASM 200
    GVLNLGDMIG RAFGTTKTKT KKMLVKEAMS IILSEESEKL IDQEKIIQQA 250
    INLVENDGIV FIDEIDKIAS VANSGAKNSE ISREGVQKDL LPLIEGTTVN 300
    TKYGPVKTDH ILFIASGAFH IAKPSDLLPE LQGRLPIRVE LNSLTKEDMI 350
    KILLEPETSL IKQYSALIGT EKVELEFTNS AIEKIADYAT TVNLEIEDIG 400
    ARRLHTILEN LLEDISFRAS EMQGEKISID DKFVENQLSK ILTNLDLAKF 450
    VL 452
    Length:452
    Mass (Da):49,865
    Last modified:May 16, 2006 - v1
    Checksum:i59DE8AA2EDCA649D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04897.1.
    RefSeqiYP_537986.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04897; ABE04897; RBE_0816.
    GeneIDi3996279.
    KEGGirbe:RBE_0816.
    PATRICi17883133. VBIRicBel102610_0930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04897.1 .
    RefSeqi YP_537986.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RIB7.
    SMRi Q1RIB7. Positions 17-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0816.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04897 ; ABE04897 ; RBE_0816 .
    GeneIDi 3996279.
    KEGGi rbe:RBE_0816.
    PATRICi 17883133. VBIRicBel102610_0930.

    Phylogenomic databases

    eggNOGi COG1220.
    HOGENOMi HOG000010036.
    KOi K03667.
    OMAi PVGVEIM.
    OrthoDBi EOG6NPM7G.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-838-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00249. HslU.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004491. HslU.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11262:SF3. PTHR11262:SF3. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00390. hslU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiHSLU_RICBR
    AccessioniPrimary (citable) accession number: Q1RIB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3