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Q1RIB7 (HSLU_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent protease ATPase subunit HslU
Alternative name(s):
Unfoldase HslU
Gene names
Name:hslU
Ordered Locus Names:RBE_0816
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis By similarity. HAMAP-Rule MF_00249

Subunit structure

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00249.

Sequence similarities

Belongs to the ClpX chaperone family. HslU subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein unfolding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentHslUV protease complex

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

peptidase activity, acting on L-amino acid peptides

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452ATP-dependent protease ATPase subunit HslU HAMAP-Rule MF_00249
PRO_0000277980

Regions

Nucleotide binding73 – 786ATP By similarity

Sites

Binding site311ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2631ATP By similarity
Binding site3301ATP By similarity
Binding site4021ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RIB7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 59DE8AA2EDCA649D

FASTA45249,865
        10         20         30         40         50         60 
MKSTKTTNTN KKDPMGLTPS QIVNELNRFI VGQEKAKKAV AIALRNRGRR KRVEGNLRNE 

        70         80         90        100        110        120 
IVPKNILMIG STGVGKTEIA RRLAKLTNSP FYKIEATKFT EVGYVGRDVE SIIRDLVEIA 

       130        140        150        160        170        180 
VNTQKTIAKT EVDINAREKA IERVLESLVG KTSSSKTREK FQEKILSGEL DDTEIEISVA 

       190        200        210        220        230        240 
DTAPVGGGSF EIPGMPGASM GVLNLGDMIG RAFGTTKTKT KKMLVKEAMS IILSEESEKL 

       250        260        270        280        290        300 
IDQEKIIQQA INLVENDGIV FIDEIDKIAS VANSGAKNSE ISREGVQKDL LPLIEGTTVN 

       310        320        330        340        350        360 
TKYGPVKTDH ILFIASGAFH IAKPSDLLPE LQGRLPIRVE LNSLTKEDMI KILLEPETSL 

       370        380        390        400        410        420 
IKQYSALIGT EKVELEFTNS AIEKIADYAT TVNLEIEDIG ARRLHTILEN LLEDISFRAS 

       430        440        450 
EMQGEKISID DKFVENQLSK ILTNLDLAKF VL 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04897.1.
RefSeqYP_537986.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RIB7.
SMRQ1RIB7. Positions 17-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0816.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04897; ABE04897; RBE_0816.
GeneID3996279.
KEGGrbe:RBE_0816.
PATRIC17883133. VBIRicBel102610_0930.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1220.
HOGENOMHOG000010036.
KOK03667.
OMAPVGVEIM.
OrthoDBEOG6NPM7G.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-838-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00249. HslU.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11262:SF3. PTHR11262:SF3. 1 hit.
PfamPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00390. hslU. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHSLU_RICBR
AccessionPrimary (citable) accession number: Q1RIB7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names