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Q1RIB7

- HSLU_RICBR

UniProt

Q1RIB7 - HSLU_RICBR

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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei263 – 2631ATPUniRule annotation
Binding sitei330 – 3301ATPUniRule annotation
Binding sitei402 – 4021ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 786ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. peptidase activity, acting on L-amino acid peptides Source: InterPro

GO - Biological processi

  1. protein unfolding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-838-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:RBE_0816
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. HslUV protease complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452ATP-dependent protease ATPase subunit HslUPRO_0000277980Add
BLAST

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi336407.RBE_0816.

Structurei

3D structure databases

ProteinModelPortaliQ1RIB7.
SMRiQ1RIB7. Positions 17-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1220.
HOGENOMiHOG000010036.
KOiK03667.
OMAiPVGVEIM.
OrthoDBiEOG6NPM7G.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00249. HslU.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11262:SF3. PTHR11262:SF3. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RIB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSTKTTNTN KKDPMGLTPS QIVNELNRFI VGQEKAKKAV AIALRNRGRR
60 70 80 90 100
KRVEGNLRNE IVPKNILMIG STGVGKTEIA RRLAKLTNSP FYKIEATKFT
110 120 130 140 150
EVGYVGRDVE SIIRDLVEIA VNTQKTIAKT EVDINAREKA IERVLESLVG
160 170 180 190 200
KTSSSKTREK FQEKILSGEL DDTEIEISVA DTAPVGGGSF EIPGMPGASM
210 220 230 240 250
GVLNLGDMIG RAFGTTKTKT KKMLVKEAMS IILSEESEKL IDQEKIIQQA
260 270 280 290 300
INLVENDGIV FIDEIDKIAS VANSGAKNSE ISREGVQKDL LPLIEGTTVN
310 320 330 340 350
TKYGPVKTDH ILFIASGAFH IAKPSDLLPE LQGRLPIRVE LNSLTKEDMI
360 370 380 390 400
KILLEPETSL IKQYSALIGT EKVELEFTNS AIEKIADYAT TVNLEIEDIG
410 420 430 440 450
ARRLHTILEN LLEDISFRAS EMQGEKISID DKFVENQLSK ILTNLDLAKF

VL
Length:452
Mass (Da):49,865
Last modified:May 16, 2006 - v1
Checksum:i59DE8AA2EDCA649D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04897.1.
RefSeqiWP_011477484.1. NC_007940.1.
YP_537986.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04897; ABE04897; RBE_0816.
GeneIDi3996279.
KEGGirbe:RBE_0816.
PATRICi17883133. VBIRicBel102610_0930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04897.1 .
RefSeqi WP_011477484.1. NC_007940.1.
YP_537986.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RIB7.
SMRi Q1RIB7. Positions 17-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04897 ; ABE04897 ; RBE_0816 .
GeneIDi 3996279.
KEGGi rbe:RBE_0816.
PATRICi 17883133. VBIRicBel102610_0930.

Phylogenomic databases

eggNOGi COG1220.
HOGENOMi HOG000010036.
KOi K03667.
OMAi PVGVEIM.
OrthoDBi EOG6NPM7G.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-838-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00249. HslU.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11262:SF3. PTHR11262:SF3. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00390. hslU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiHSLU_RICBR
AccessioniPrimary (citable) accession number: Q1RIB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3