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Q1RIB3 (DHAS_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate-semialdehyde dehydrogenase
Short name=ASA dehydrogenase
Short name=ASADH
EC=1.2.1.11
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenase
Gene names
Name:asd
Ordered Locus Names:RBE_0820
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate By similarity. HAMAP MF_02121

Catalytic activity

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH. HAMAP MF_02121

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. HAMAP MF_02121

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. HAMAP MF_02121

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5. HAMAP MF_02121

Subunit structure

Homodimer By similarity. HAMAP MF_02121

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Aspartate-semialdehyde dehydrogenase HAMAP MF_02121
PRO_0000280937

Regions

Nucleotide binding13 – 164NADP By similarity
Nucleotide binding41 – 422NADP By similarity
Nucleotide binding162 – 1632NADP By similarity

Sites

Active site1321Acyl-thioester intermediate By similarity
Active site2441Proton acceptor By similarity
Binding site1011Phosphate By similarity
Binding site1591Substrate By similarity
Binding site2161Phosphate By similarity
Binding site2371Substrate By similarity
Binding site3171NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RIB3 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 9177EB9C54C1B233

FASTA33837,273
        10         20         30         40         50         60 
MTKKYNIAVI GATGNVGRET LNILAERNFP INKIYAVASN NSIGKKVSFG EQVLQISSLD 

        70         80         90        100        110        120 
DLDFEEIDIA FFSAGSEVSK KFIPIAIVKN CMVIDKSSFF RLSEDIPLIV PEANLSTLKD 

       130        140        150        160        170        180 
FAIKNIISNP NCIAIPLAVV LKPLDNEISI KRVVISTYQS VSGAGKAGMD ELYDQTKSKY 

       190        200        210        220        230        240 
IFEEKSPNIF PKQIAFNLFP HIGDLNKDGY TSEESKIALE LQKIIGDHLK VSVTSVRVPV 

       250        260        270        280        290        300 
FVGHSISVNI EFSSKVDAKE VEEILEDADG VVMISQTKDL AYISPTEVVG EDAVYVSRIR 

       310        320        330 
DDESKENAIN LWITCDNLRK GAALNSVQIA EELIKTYL

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000087 Genomic DNA. Translation: ABE04901.1.
RefSeqYP_537990.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RIB3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1RIB3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3996283.
GenomeReviewsGene locus RBE_0820 in contig CP000087_GR.
KEGGrbe:RBE_0820.
PATRIC17883141. VBIRicBel102610_0934.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0136.
HOGENOMHBG518238.
OMAYQSTSGA.
ProtClustDBPRK14874.

Enzyme and pathway databases

BioCycRBEL336407:RBE_0820-MONOMER.

Family and domain databases

HAMAPMF_02121. ASADH.
[Tree]
InterProIPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_beta.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00133.
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFPIRSF000148. ASA_dh. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01296. Asd_B. 1 hit.
PROSITEPS01103. ASD. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHAS_RICBR
AccessionPrimary (citable) accession number: Q1RIB3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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