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Q1RI93 (COXX_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoheme IX farnesyltransferase

EC=2.5.1.-
Alternative name(s):
Heme O synthase
Gene names
Name:ctaB
Ordered Locus Names:RBE_0840
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts protoheme IX and farnesyl diphosphate to heme O By similarity. HAMAP-Rule MF_00154

Pathway

Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. HAMAP-Rule MF_00154

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00154.

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme O biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotoheme IX farnesyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Protoheme IX farnesyltransferase HAMAP-Rule MF_00154
PRO_0000274892

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane123 – 14523Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane280 – 30021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1RI93 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: AB1F8546D86ECB68

FASTA30033,748
        10         20         30         40         50         60 
MNSLTKSINL DKVSYPQSTV KDYILLMKPR VMSLVVFTGF SGMWLAPNSL HPFISVIALI 

        70         80         90        100        110        120 
CIAIGAGSAG AINMWYDRDI DALMKRTQKR PIVRGAIEAD EALSFGLIMA FFSVFFMALC 

       130        140        150        160        170        180 
VNFLSALLLL FTIFYYICIY TMWLKRSSIQ NIVIGGAAGA LPPVIGYASV SGSVSLDSVI 

       190        200        210        220        230        240 
LFLIIFIWTP PHSWALALFC NDDYKNCKVP MMPVIKGALY TKKQILIYSV LLFLTSLKPF 

       250        260        270        280        290        300 
FVGMSNIIYL VIAAVLGLVF LYYSISLFYD NADNKQAKRF FAYSIFYLFF IFLLLDFCRV 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04921.1.
RefSeqYP_538010.1. NC_007940.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04921; ABE04921; RBE_0840.
GeneID3995135.
KEGGrbe:RBE_0840.
PATRIC17883185. VBIRicBel102610_0956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0109.
HOGENOMHOG000237291.
KOK02301.
OMAGMWTLYT.
OrthoDBEOG6DVJQB.
ProtClustDBPRK04375.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-862-MONOMER.
UniPathwayUPA00834; UER00712.

Family and domain databases

HAMAPMF_00154. CyoE_CtaB.
InterProIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01473. cyoE_ctaB. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOXX_RICBR
AccessionPrimary (citable) accession number: Q1RI93
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways