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Q1RI47

- LSPA_RICBR

UniProt

Q1RI47 - LSPA_RICBR

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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171UniRule annotation
Active sitei144 – 1441UniRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-908-MONOMER.
UniPathwayiUPA00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:RBE_0886
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei75 – 9521HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11721HelicalUniRule annotationAdd
BLAST
Transmembranei135 – 15521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Lipoprotein signal peptidasePRO_0000278077Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0886.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096992.
KOiK03101.
OMAiDCAITVG.
OrthoDBiEOG6PGKBM.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RI47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILSFKKLYL TFARSSRIII TLVIIDQLTK WWFINNLRWK PGLTLKVTSF
60 70 80 90 100
LNMVYTWNYG ISFGLMRDYY QYSNIVFLIT NTIIVCYLYY LMMSSKTIGG
110 120 130 140 150
FAGYSFVIGG AIGNLIDRSF RGAVFDFIHF YYQDYSFPVF NLADCFITLG
160 170 180 190
VIILVEDYYS AKKNIEEKAK ENYDKAQIEA MAEKIRNAPQ GDNDKI
Length:196
Mass (Da):22,852
Last modified:May 16, 2006 - v1
Checksum:iDBA4772E501F0568
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04967.1.
RefSeqiYP_538056.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04967; ABE04967; RBE_0886.
GeneIDi3995759.
KEGGirbe:RBE_0886.
PATRICi17883289. VBIRicBel102610_1008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04967.1 .
RefSeqi YP_538056.1. NC_007940.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04967 ; ABE04967 ; RBE_0886 .
GeneIDi 3995759.
KEGGi rbe:RBE_0886.
PATRICi 17883289. VBIRicBel102610_1008.

Phylogenomic databases

eggNOGi COG0597.
HOGENOMi HOG000096992.
KOi K03101.
OMAi DCAITVG.
OrthoDBi EOG6PGKBM.

Enzyme and pathway databases

UniPathwayi UPA00665 .
BioCyci RBEL336407:GJCY-908-MONOMER.

Family and domain databases

HAMAPi MF_00161. LspA.
InterProi IPR001872. Peptidase_A8.
[Graphical view ]
Pfami PF01252. Peptidase_A8. 1 hit.
[Graphical view ]
PRINTSi PR00781. LIPOSIGPTASE.
TIGRFAMsi TIGR00077. lspA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiLSPA_RICBR
AccessioniPrimary (citable) accession number: Q1RI47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3