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Q1RI44 (COX2_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RBE_0889
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Probable cytochrome c oxidase subunit 2
PRO_0000280886

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane87 – 10721Helical; Potential

Sites

Metal binding1891Copper A Potential
Metal binding2241Copper A Potential
Metal binding2281Copper A Potential
Metal binding2321Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q1RI44 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 14E81BB6E77F7FA2

FASTA26930,483
        10         20         30         40         50         60 
MYFMKNVITL IGLVLFSSFC FASEPLPWQM GFQPPASPIM EELHKFHDFL LYISTAIVLF 

        70         80         90        100        110        120 
VAGLLVFVCI KFNARNNPVP AKFSHNILIE IIWTVIPIII LVIIAVPSFR ILRHAEKIPE 

       130        140        150        160        170        180 
ADLTIKVVGY QWYWHYIYPD HNDIEFDSVM ISDENLKPDQ KRLLDVDNRI VIPENATVRF 

       190        200        210        220        230        240 
LITASDVIHS FAVPSLGFKI DAVPGRVNET WTRVAKKGVY YGQCSELCGI NHGFMPIAIE 

       250        260 
VVSKEDFDNW VASKNKVAAN GENSKLAAN 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04970.1.
RefSeqYP_538059.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RI44.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0889.

Proteomic databases

PRIDEQ1RI44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04970; ABE04970; RBE_0889.
GeneID3995762.
KEGGrbe:RBE_0889.
PATRIC17883295. VBIRicBel102610_1011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02275.
OMASKNKTAM.
OrthoDBEOG68SVXT.
ProtClustDBCLSK870908.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-911-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_RICBR
AccessionPrimary (citable) accession number: Q1RI44
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names