Q1RI44 (COX2_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II

Gene names

Name:	ctaC
Synonyms:	coxB
Ordered Locus Names:	RBE_0889

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A By similarity. Heme group By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Probable cytochrome c oxidase subunit 2		PRO_0000280886
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	50 – 70	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
Sites
	Metal binding	189	1	Copper A Potential
	Metal binding	224	1	Copper A Potential
	Metal binding	228	1	Copper A Potential
	Metal binding	232	1	Copper A Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RI44 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 14E81BB6E77F7FA2	FASTA	269	30,483
	10 20 30 40 50 60 MYFMKNVITL IGLVLFSSFC FASEPLPWQM GFQPPASPIM EELHKFHDFL LYISTAIVLF 70 80 90 100 110 120 VAGLLVFVCI KFNARNNPVP AKFSHNILIE IIWTVIPIII LVIIAVPSFR ILRHAEKIPE 130 140 150 160 170 180 ADLTIKVVGY QWYWHYIYPD HNDIEFDSVM ISDENLKPDQ KRLLDVDNRI VIPENATVRF 190 200 210 220 230 240 LITASDVIHS FAVPSLGFKI DAVPGRVNET WTRVAKKGVY YGQCSELCGI NHGFMPIAIE 250 260 VVSKEDFDNW VASKNKVAAN GENSKLAAN

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04970.1.
RefSeq	YP_538059.1. NC_007940.1.
3D structure databases
HSSP	HSSP built from PDB template 2FWL based on UniProtKB P98052.
ProteinModelPortal	Q1RI44.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0889.
Proteomic databases
PRIDE	Q1RI44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04970; ABE04970; RBE_0889.
GeneID	3995762.
KEGG	rbe:RBE_0889.
PATRIC	17883295. VBIRicBel102610_1011.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1622.
HOGENOM	HOG000264988.
KO	K02275.
OMA	LIEVAWT.
ProtClustDB	CLSK870908.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-911-MONOMER.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_RICBR

Accession

Primary (citable) accession number: Q1RI44

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program