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Q1RI42

- COX1_RICBR

UniProt

Q1RI42 - COX1_RICBR

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Protein

Probable cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Iron (heme A axial ligand)By similarity
Metal bindingi258 – 2581Copper BBy similarity
Metal bindingi262 – 2621Copper BBy similarity
Metal bindingi307 – 3071Copper BBy similarity
Metal bindingi308 – 3081Copper BBy similarity
Metal bindingi393 – 3931Iron (heme A3 axial ligand)By similarity
Metal bindingi395 – 3951Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-913-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RBE_0891
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Probable cytochrome c oxidase subunit 1PRO_0000280884Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0891.

Structurei

3D structure databases

ProteinModelPortaliQ1RI42.
SMRiQ1RI42. Positions 19-532.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence AnalysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
KOiK02274.
OMAiHTFEKPP.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RI42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDITTNDLNH DDHHTPHGWK RWLFSTNHKD IGIMYIIFAI FAGIVGGLFS
60 70 80 90 100
LLFRLELAMP GGTFLNHDFQ LYNVLITAHA VIMVFFMIMP ALFGGFGNYF
110 120 130 140 150
VPLLIGAPDM AFPRLNNISF WLLVPAFILL MGSAFVDGGP GTGWTLYPPL
160 170 180 190 200
SSISGHPGAA VDMAIFSLHL TGLSSILGSI NLIVTIFNMR APGMGLFKMP
210 220 230 240 250
LFVWSILVTA FLIILAMPVL GGAITMLLTD RNFGTTFFKT DGGGDPVLFQ
260 270 280 290 300
HLFWFFGHPE VYIVILPGFG IVSQVISTFS RKPIFGYQGM VGAMVIIGFV
310 320 330 340 350
GFIVWAHHMF TVGLSYNALI YFTAGTMIIA IPTGIKIFSW IATMWGGSIT
360 370 380 390 400
FPTPMLFSIG FIILFTIGGV TGIILSNSAL DRVLHDTYYV VAHFHYTMSL
410 420 430 440 450
GALFTAFAGF YYWFGKISGK QYPEILGKIH FWITFVGVNL TFFPQHFLGL
460 470 480 490 500
AGMPRRIPDY PEAFAGWNMV SSIGAGISMA AALYFVFIVF YTLKYGKDCP
510 520 530
NNPWGDGADT LEWTLTSPPP FHTFETPPHI EE
Length:532
Mass (Da):58,830
Last modified:May 16, 2006 - v1
Checksum:iA2C688048190E5DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04972.1.
RefSeqiYP_538061.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04972; ABE04972; RBE_0891.
GeneIDi3995258.
KEGGirbe:RBE_0891.
PATRICi17883301. VBIRicBel102610_1014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE04972.1 .
RefSeqi YP_538061.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RI42.
SMRi Q1RI42. Positions 19-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE04972 ; ABE04972 ; RBE_0891 .
GeneIDi 3995258.
KEGGi rbe:RBE_0891.
PATRICi 17883301. VBIRicBel102610_1014.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
KOi K02274.
OMAi HTFEKPP.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci RBEL336407:GJCY-913-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiCOX1_RICBR
AccessioniPrimary (citable) accession number: Q1RI42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3