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Q1RI42 (COX1_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RBE_0891
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Probable cytochrome c oxidase subunit 1
PRO_0000280884

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane355 – 37521Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane431 – 45121Helical; Potential
Transmembrane473 – 49321Helical; Potential

Sites

Metal binding791Iron (heme A axial ligand) By similarity
Metal binding2581Copper B By similarity
Metal binding2621Copper B By similarity
Metal binding3071Copper B By similarity
Metal binding3081Copper B By similarity
Metal binding3931Iron (heme A3 axial ligand) By similarity
Metal binding3951Iron (heme A axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RI42 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: A2C688048190E5DD

FASTA53258,830
        10         20         30         40         50         60 
MDITTNDLNH DDHHTPHGWK RWLFSTNHKD IGIMYIIFAI FAGIVGGLFS LLFRLELAMP 

        70         80         90        100        110        120 
GGTFLNHDFQ LYNVLITAHA VIMVFFMIMP ALFGGFGNYF VPLLIGAPDM AFPRLNNISF 

       130        140        150        160        170        180 
WLLVPAFILL MGSAFVDGGP GTGWTLYPPL SSISGHPGAA VDMAIFSLHL TGLSSILGSI 

       190        200        210        220        230        240 
NLIVTIFNMR APGMGLFKMP LFVWSILVTA FLIILAMPVL GGAITMLLTD RNFGTTFFKT 

       250        260        270        280        290        300 
DGGGDPVLFQ HLFWFFGHPE VYIVILPGFG IVSQVISTFS RKPIFGYQGM VGAMVIIGFV 

       310        320        330        340        350        360 
GFIVWAHHMF TVGLSYNALI YFTAGTMIIA IPTGIKIFSW IATMWGGSIT FPTPMLFSIG 

       370        380        390        400        410        420 
FIILFTIGGV TGIILSNSAL DRVLHDTYYV VAHFHYTMSL GALFTAFAGF YYWFGKISGK 

       430        440        450        460        470        480 
QYPEILGKIH FWITFVGVNL TFFPQHFLGL AGMPRRIPDY PEAFAGWNMV SSIGAGISMA 

       490        500        510        520        530 
AALYFVFIVF YTLKYGKDCP NNPWGDGADT LEWTLTSPPP FHTFETPPHI EE 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04972.1.
RefSeqYP_538061.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RI42.
SMRQ1RI42. Positions 19-532.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0891.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04972; ABE04972; RBE_0891.
GeneID3995258.
KEGGrbe:RBE_0891.
PATRIC17883301. VBIRicBel102610_1014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085275.
KOK02274.
OMAHTFEKPP.
OrthoDBEOG6B35XR.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-913-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_RICBR
AccessionPrimary (citable) accession number: Q1RI42
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways