Q1RI36 (SECA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein translocase subunit SecA

Gene names

Name:	secA
Ordered Locus Names:	RBE_0897

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382
Cofactor	May bind 1 zinc ion per subunit Potential.
Subunit structure	Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382
Sequence similarities	Belongs to the SecA family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein import Inferred from electronic annotation. Source: InterPro protein targeting Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 910	910	Protein translocase subunit SecA HAMAP-Rule MF_01382		PRO_0000277299
Regions
	Nucleotide binding	101 – 108	8	ATP Potential
Sites
	Metal binding	894	1	Zinc Potential
	Metal binding	896	1	Zinc Potential
	Metal binding	905	1	Zinc Potential
	Metal binding	906	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RI36 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: C4FD4D044614D91F	FASTA	910	103,716
	10 20 30 40 50 60 MFSILKKIFG TANDRTIKKL FSDIAKINSL EPAIQKLSDE ELKNKTVEFK KKLKNGATLD 70 80 90 100 110 120 DIAYEAFAVV REASRRVYGM RHFDVQLIGG LVLHRGMITE MRTGEGKTLV ATLPAYLNAL 130 140 150 160 170 180 AEKGVHVVTV NDYLVSRDSA SMGKIYNFLG LSVGCIVAGM TDEAKREAYN SDITYATNNE 190 200 210 220 230 240 LGFDYLRDNM KYSLQERVLR PFNFAIIDEV DSILIDEART PLVISGPVND NSELYGKVDK 250 260 270 280 290 300 LVRMLNVSDF EKDEKLKTIN LTESGISHVE SLLSQADIIK PNSGLYDFEN LSLVHYVNQA 310 320 330 340 350 360 LRAHNMFMID VDYLVRDGKV MIIDEFTGRV MEGRRYSEGL HQALEAKENV KIQNENQTLA 370 380 390 400 410 420 SITFQNYFRN YPKLSGMTGT AMTEAPELKD IYNLDVVAVP THNKVTRRDL DDEIYGSKKE 430 440 450 460 470 480 KYDAILKLIK DCYDRGQPVL VGTVSIEKSE EISNVLNKNK IPHKVLNAKF HEQEAFIIAQ 490 500 510 520 530 540 AGRFKAVTIA TNMAGRGTDI MLGGNPEMLI EQIDRKSLTN AAYKEKVNEI KAQTAEEKKQ 550 560 570 580 590 600 VIAAGGLFVI GTERHESRRI DNQLRGRSGR QGDPGNTKFF LSLDDDLMRI FASERISGVL 610 620 630 640 650 660 RTLGLKDGEA IHHPMISRSL EKAQQKVEGH NYEIRKNLLR FDDVMNDQRK IIYEQRTEII 670 680 690 700 710 720 KSKDSYDFLS STTEELAKKI VLTFMPAGSY REDWDIENLS VELHRTFAIK LDQNLISKND 730 740 750 760 770 780 VTEEEVTKIV IQTADSIYKS KEEAYSPDLM HNAVKYILLT TLDQVWKDHL HSLDHLRQGI 790 800 810 820 830 840 SLRAYAQKDP LSEYKREAFN LFEHMLNNLK ELFIQTVYHF HIDLKHIQKE DISLENKKLQ 850 860 870 880 890 900 NNMHESREDP AFSKYNAGSN LETDLRPVIS RINPEDRDPK NPTSWGKVSR NELCPCGSGK 910 KYKYCHGLNE

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04978.1.
RefSeq	YP_538067.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RI36.
SMR	Q1RI36. Positions 13-231.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0897.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04978; ABE04978; RBE_0897.
GeneID	3995264.
KEGG	rbe:RBE_0897.
PATRIC	17883315. VBIRicBel102610_1021.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0653.
HOGENOM	HOG000218168.
KO	K03070.
OMA	ERFFILQ.
ProtClustDB	PRK12904.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-919-MONOMER.
Family and domain databases
Gene3D	1.10.3060.10. 1 hit. 3.90.1440.10. 1 hit.
HAMAP	MF_01382. SecA.
InterPro	IPR004027. SEC_C_motif. IPR000185. SecA. IPR020937. SecA_CS. IPR011115. SecA_DEAD. IPR014018. SecA_motor_DEAD. IPR011130. SecA_preprotein_X-link_dom. IPR011116. SecA_Wing/Scaffold. [Graphical view]
Pfam	PF02810. SEC-C. 1 hit. PF07517. SecA_DEAD. 1 hit. PF01043. SecA_PP_bind. 1 hit. PF07516. SecA_SW. 1 hit. [Graphical view]
PRINTS	PR00906. SECA.
SMART	SM00957. SecA_DEAD. 1 hit. SM00958. SecA_PP_bind. 1 hit. [Graphical view]
SUPFAM	SSF81767. SecA_PP_bd. 1 hit. SSF81886. SecA_SW. 1 hit.
TIGRFAMs	TIGR00963. secA. 1 hit.
PROSITE	PS01312. SECA. 1 hit. PS51196. SECA_MOTOR_DEAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SECA_RICBR

Accession

Primary (citable) accession number: Q1RI36

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program