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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi894 – 8941ZincUniRule annotation
Metal bindingi896 – 8961ZincUniRule annotation
Metal bindingi905 – 9051ZincUniRule annotation
Metal bindingi906 – 9061ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-919-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:RBE_0897
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Protein translocase subunit SecAPRO_0000277299Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RI36.
SMRiQ1RI36. Positions 13-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RI36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSILKKIFG TANDRTIKKL FSDIAKINSL EPAIQKLSDE ELKNKTVEFK
60 70 80 90 100
KKLKNGATLD DIAYEAFAVV REASRRVYGM RHFDVQLIGG LVLHRGMITE
110 120 130 140 150
MRTGEGKTLV ATLPAYLNAL AEKGVHVVTV NDYLVSRDSA SMGKIYNFLG
160 170 180 190 200
LSVGCIVAGM TDEAKREAYN SDITYATNNE LGFDYLRDNM KYSLQERVLR
210 220 230 240 250
PFNFAIIDEV DSILIDEART PLVISGPVND NSELYGKVDK LVRMLNVSDF
260 270 280 290 300
EKDEKLKTIN LTESGISHVE SLLSQADIIK PNSGLYDFEN LSLVHYVNQA
310 320 330 340 350
LRAHNMFMID VDYLVRDGKV MIIDEFTGRV MEGRRYSEGL HQALEAKENV
360 370 380 390 400
KIQNENQTLA SITFQNYFRN YPKLSGMTGT AMTEAPELKD IYNLDVVAVP
410 420 430 440 450
THNKVTRRDL DDEIYGSKKE KYDAILKLIK DCYDRGQPVL VGTVSIEKSE
460 470 480 490 500
EISNVLNKNK IPHKVLNAKF HEQEAFIIAQ AGRFKAVTIA TNMAGRGTDI
510 520 530 540 550
MLGGNPEMLI EQIDRKSLTN AAYKEKVNEI KAQTAEEKKQ VIAAGGLFVI
560 570 580 590 600
GTERHESRRI DNQLRGRSGR QGDPGNTKFF LSLDDDLMRI FASERISGVL
610 620 630 640 650
RTLGLKDGEA IHHPMISRSL EKAQQKVEGH NYEIRKNLLR FDDVMNDQRK
660 670 680 690 700
IIYEQRTEII KSKDSYDFLS STTEELAKKI VLTFMPAGSY REDWDIENLS
710 720 730 740 750
VELHRTFAIK LDQNLISKND VTEEEVTKIV IQTADSIYKS KEEAYSPDLM
760 770 780 790 800
HNAVKYILLT TLDQVWKDHL HSLDHLRQGI SLRAYAQKDP LSEYKREAFN
810 820 830 840 850
LFEHMLNNLK ELFIQTVYHF HIDLKHIQKE DISLENKKLQ NNMHESREDP
860 870 880 890 900
AFSKYNAGSN LETDLRPVIS RINPEDRDPK NPTSWGKVSR NELCPCGSGK
910
KYKYCHGLNE
Length:910
Mass (Da):103,716
Last modified:May 16, 2006 - v1
Checksum:iC4FD4D044614D91F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04978.1.
RefSeqiWP_011477563.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04978; ABE04978; RBE_0897.
KEGGirbe:RBE_0897.
PATRICi17883315. VBIRicBel102610_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04978.1.
RefSeqiWP_011477563.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RI36.
SMRiQ1RI36. Positions 13-231.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE04978; ABE04978; RBE_0897.
KEGGirbe:RBE_0897.
PATRICi17883315. VBIRicBel102610_1021.

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-919-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiSECA_RICBR
AccessioniPrimary (citable) accession number: Q1RI36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 16, 2006
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.