Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1RHX0

- MURC_RICBR

UniProt

Q1RHX0 - MURC_RICBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi120 – 1267ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-988-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligaseUniRule annotation (EC:6.3.2.8UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetaseUniRule annotation
Gene namesi
Name:murCUniRule annotation
Ordered Locus Names:RBE_0963
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478UDP-N-acetylmuramate--L-alanine ligasePRO_0000242589Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0963.

Structurei

3D structure databases

ProteinModelPortaliQ1RHX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0773.
HOGENOMiHOG000256031.
KOiK01924.
OMAiVMVFQPH.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RHX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLELKKTN QTLETIHFIG IGGVGMSGIA EILHNLGYKV QGSDLSENYN
60 70 80 90 100
TKRLEAYGIK IFVGHTPQNI TNVSYVVVSS AINRNNPEVK EALERKIPII
110 120 130 140 150
RRAEMLAELM RLKCSVAVSG SHGKTTTTSL VACLFEAAGL HPTVINGGII
160 170 180 190 200
NNRSTNAYLG SSNYLIAEAD ESDATFISIP STIAIITNID PEHLDYYKDF
210 220 230 240 250
DTLINAFRSF ITNLPFYGFA VCCIDHKIVR ELVNNITERK VITYGIDSDD
260 270 280 290 300
AHITAFNIST DITSSTFDVK ISLPNVSGVT IIEKITIPTP GRHNILNSLA
310 320 330 340 350
AISVGVELDF GIKAIKNGFN SFKGVKRRFT KVAEYNQASV IDDYAHHPEE
360 370 380 390 400
IKATLSTAKN IANKQHGKVI AIFQPHRYSR MQHLFDDFMR CFDDADLLYI
410 420 430 440 450
TDVYAAGESP IEGISGQSLI DNIIKLKYHN QANFLAKLDD SLEVIMNKAS
460 470
PGDMIIMMGA GNISNFANEL PQKFGNLS
Length:478
Mass (Da):52,672
Last modified:May 16, 2006 - v1
Checksum:i676C617047ED8D14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05044.1.
RefSeqiWP_011477624.1. NC_007940.1.
YP_538133.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05044; ABE05044; RBE_0963.
GeneIDi3995058.
KEGGirbe:RBE_0963.
PATRICi17883465. VBIRicBel102610_1093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05044.1 .
RefSeqi WP_011477624.1. NC_007940.1.
YP_538133.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RHX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0963.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05044 ; ABE05044 ; RBE_0963 .
GeneIDi 3995058.
KEGGi rbe:RBE_0963.
PATRICi 17883465. VBIRicBel102610_1093.

Phylogenomic databases

eggNOGi COG0773.
HOGENOMi HOG000256031.
KOi K01924.
OMAi VMVFQPH.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci RBEL336407:GJCY-988-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01082. murC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiMURC_RICBR
AccessioniPrimary (citable) accession number: Q1RHX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3