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Q1RHX0

- MURC_RICBR

UniProt

Q1RHX0 - MURC_RICBR

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Protein
UDP-N-acetylmuramate--L-alanine ligase
Gene
murC, RBE_0963
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi120 – 1267ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-988-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene namesi
Name:murC
Ordered Locus Names:RBE_0963
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478UDP-N-acetylmuramate--L-alanine ligaseUniRule annotation
PRO_0000242589Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0963.

Structurei

3D structure databases

ProteinModelPortaliQ1RHX0.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.

Phylogenomic databases

eggNOGiCOG0773.
HOGENOMiHOG000256031.
KOiK01924.
OMAiVMVFQPH.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RHX0-1 [UniParc]FASTAAdd to Basket

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MLLLELKKTN QTLETIHFIG IGGVGMSGIA EILHNLGYKV QGSDLSENYN    50
TKRLEAYGIK IFVGHTPQNI TNVSYVVVSS AINRNNPEVK EALERKIPII 100
RRAEMLAELM RLKCSVAVSG SHGKTTTTSL VACLFEAAGL HPTVINGGII 150
NNRSTNAYLG SSNYLIAEAD ESDATFISIP STIAIITNID PEHLDYYKDF 200
DTLINAFRSF ITNLPFYGFA VCCIDHKIVR ELVNNITERK VITYGIDSDD 250
AHITAFNIST DITSSTFDVK ISLPNVSGVT IIEKITIPTP GRHNILNSLA 300
AISVGVELDF GIKAIKNGFN SFKGVKRRFT KVAEYNQASV IDDYAHHPEE 350
IKATLSTAKN IANKQHGKVI AIFQPHRYSR MQHLFDDFMR CFDDADLLYI 400
TDVYAAGESP IEGISGQSLI DNIIKLKYHN QANFLAKLDD SLEVIMNKAS 450
PGDMIIMMGA GNISNFANEL PQKFGNLS 478
Length:478
Mass (Da):52,672
Last modified:May 16, 2006 - v1
Checksum:i676C617047ED8D14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05044.1.
RefSeqiYP_538133.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05044; ABE05044; RBE_0963.
GeneIDi3995058.
KEGGirbe:RBE_0963.
PATRICi17883465. VBIRicBel102610_1093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05044.1 .
RefSeqi YP_538133.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RHX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0963.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05044 ; ABE05044 ; RBE_0963 .
GeneIDi 3995058.
KEGGi rbe:RBE_0963.
PATRICi 17883465. VBIRicBel102610_1093.

Phylogenomic databases

eggNOGi COG0773.
HOGENOMi HOG000256031.
KOi K01924.
OMAi VMVFQPH.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci RBEL336407:GJCY-988-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01082. murC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiMURC_RICBR
AccessioniPrimary (citable) accession number: Q1RHX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 16, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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