Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1RHX0 (MURC_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase

EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:RBE_0963
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478UDP-N-acetylmuramate--L-alanine ligase HAMAP-Rule MF_00046
PRO_0000242589

Regions

Nucleotide binding120 – 1267ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q1RHX0 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 676C617047ED8D14

FASTA47852,672
        10         20         30         40         50         60 
MLLLELKKTN QTLETIHFIG IGGVGMSGIA EILHNLGYKV QGSDLSENYN TKRLEAYGIK 

        70         80         90        100        110        120 
IFVGHTPQNI TNVSYVVVSS AINRNNPEVK EALERKIPII RRAEMLAELM RLKCSVAVSG 

       130        140        150        160        170        180 
SHGKTTTTSL VACLFEAAGL HPTVINGGII NNRSTNAYLG SSNYLIAEAD ESDATFISIP 

       190        200        210        220        230        240 
STIAIITNID PEHLDYYKDF DTLINAFRSF ITNLPFYGFA VCCIDHKIVR ELVNNITERK 

       250        260        270        280        290        300 
VITYGIDSDD AHITAFNIST DITSSTFDVK ISLPNVSGVT IIEKITIPTP GRHNILNSLA 

       310        320        330        340        350        360 
AISVGVELDF GIKAIKNGFN SFKGVKRRFT KVAEYNQASV IDDYAHHPEE IKATLSTAKN 

       370        380        390        400        410        420 
IANKQHGKVI AIFQPHRYSR MQHLFDDFMR CFDDADLLYI TDVYAAGESP IEGISGQSLI 

       430        440        450        460        470 
DNIIKLKYHN QANFLAKLDD SLEVIMNKAS PGDMIIMMGA GNISNFANEL PQKFGNLS 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05044.1.
RefSeqYP_538133.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RHX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0963.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05044; ABE05044; RBE_0963.
GeneID3995058.
KEGGrbe:RBE_0963.
PATRIC17883465. VBIRicBel102610_1093.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0773.
HOGENOMHOG000256031.
KOK01924.
OMAVVQPHRY.
OrthoDBEOG64BQ73.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-988-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00046. MurC.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsTIGR01082. murC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_RICBR
AccessionPrimary (citable) accession number: Q1RHX0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways