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Q1RHX0

- MURC_RICBR

UniProt

Q1RHX0 - MURC_RICBR

Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi120 – 1267ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-988-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramate--L-alanine ligaseUniRule annotation (EC:6.3.2.8UniRule annotation)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetaseUniRule annotation
    Gene namesi
    Name:murCUniRule annotation
    Ordered Locus Names:RBE_0963
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478UDP-N-acetylmuramate--L-alanine ligasePRO_0000242589Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RHX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0773.
    HOGENOMiHOG000256031.
    KOiK01924.
    OMAiVMVFQPH.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01082. murC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RHX0-1 [UniParc]FASTAAdd to Basket

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    MLLLELKKTN QTLETIHFIG IGGVGMSGIA EILHNLGYKV QGSDLSENYN    50
    TKRLEAYGIK IFVGHTPQNI TNVSYVVVSS AINRNNPEVK EALERKIPII 100
    RRAEMLAELM RLKCSVAVSG SHGKTTTTSL VACLFEAAGL HPTVINGGII 150
    NNRSTNAYLG SSNYLIAEAD ESDATFISIP STIAIITNID PEHLDYYKDF 200
    DTLINAFRSF ITNLPFYGFA VCCIDHKIVR ELVNNITERK VITYGIDSDD 250
    AHITAFNIST DITSSTFDVK ISLPNVSGVT IIEKITIPTP GRHNILNSLA 300
    AISVGVELDF GIKAIKNGFN SFKGVKRRFT KVAEYNQASV IDDYAHHPEE 350
    IKATLSTAKN IANKQHGKVI AIFQPHRYSR MQHLFDDFMR CFDDADLLYI 400
    TDVYAAGESP IEGISGQSLI DNIIKLKYHN QANFLAKLDD SLEVIMNKAS 450
    PGDMIIMMGA GNISNFANEL PQKFGNLS 478
    Length:478
    Mass (Da):52,672
    Last modified:May 16, 2006 - v1
    Checksum:i676C617047ED8D14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05044.1.
    RefSeqiYP_538133.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05044; ABE05044; RBE_0963.
    GeneIDi3995058.
    KEGGirbe:RBE_0963.
    PATRICi17883465. VBIRicBel102610_1093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05044.1 .
    RefSeqi YP_538133.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RHX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0963.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05044 ; ABE05044 ; RBE_0963 .
    GeneIDi 3995058.
    KEGGi rbe:RBE_0963.
    PATRICi 17883465. VBIRicBel102610_1093.

    Phylogenomic databases

    eggNOGi COG0773.
    HOGENOMi HOG000256031.
    KOi K01924.
    OMAi VMVFQPH.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci RBEL336407:GJCY-988-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01082. murC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiMURC_RICBR
    AccessioniPrimary (citable) accession number: Q1RHX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3