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Q1RHV0

- FOLD_RICBR

UniProt

Q1RHV0 - FOLD_RICBR

Protein

Bifunctional protein FolD

Gene

folD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
    5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei191 – 1911NADPUniRule annotation
    Binding sitei232 – 2321NADP; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi166 – 1683NADPUniRule annotation

    GO - Molecular functioni

    1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-HAMAP
    2. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. histidine biosynthetic process Source: UniProtKB-KW
    3. methionine biosynthetic process Source: UniProtKB-KW
    4. purine nucleotide biosynthetic process Source: UniProtKB-KW
    5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1008-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein FolDUniRule annotation
    Including the following 2 domains:
    Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
    Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
    Gene namesi
    Name:folDUniRule annotation
    Ordered Locus Names:RBE_0983
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Bifunctional protein FolDPRO_0000268479Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0983.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RHV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0190.
    HOGENOMiHOG000218242.
    KOiK01491.
    OMAiCHSKSIY.
    OrthoDBiEOG6K6VBB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01576. THF_DHG_CYH.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view]
    PRINTSiPR00085. THFDHDRGNASE.
    PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RHV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNVIDGKAL ANEILSELKH EVQRLKDKTG ESPKLAIVLV GDNPASIIYV    50
    KNKIKHANKI GIDTLLLNLP ITIKTEDLIA KISELNLDQN VSGIIVQLPL 100
    PNSIDKNKIL SAISPSKDVD GFHPLNVGYL HSGIDNGFVP CTALGCLEVI 150
    KKHEPNLSGK NAIIVGRSNI VGKPLSALLL KENCSVTICH SKSQNLSSIT 200
    SKADIVVAAI GSPLKLTSGY FKPDAIVIDV GINRIGGNKI VGDVDFENVK 250
    SKVKYITPVP GGIGPMTIAF LLKNTVQAFK IYS 283
    Length:283
    Mass (Da):30,267
    Last modified:May 16, 2006 - v1
    Checksum:i87E98A365290B10F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05064.1.
    RefSeqiYP_538153.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05064; ABE05064; RBE_0983.
    GeneIDi3995125.
    KEGGirbe:RBE_0983.
    PATRICi17883509. VBIRicBel102610_1115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05064.1 .
    RefSeqi YP_538153.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RHV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05064 ; ABE05064 ; RBE_0983 .
    GeneIDi 3995125.
    KEGGi rbe:RBE_0983.
    PATRICi 17883509. VBIRicBel102610_1115.

    Phylogenomic databases

    eggNOGi COG0190.
    HOGENOMi HOG000218242.
    KOi K01491.
    OMAi CHSKSIY.
    OrthoDBi EOG6K6VBB.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RBEL336407:GJCY-1008-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01576. THF_DHG_CYH.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00085. THFDHDRGNASE.
    PROSITEi PS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiFOLD_RICBR
    AccessioniPrimary (citable) accession number: Q1RHV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3