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Q1RHV0 (FOLD_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional protein FolD

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD
Ordered Locus Names:RBE_0983
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP-Rule MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP-Rule MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP-Rule MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01576

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Bifunctional protein FolD HAMAP-Rule MF_01576
PRO_0000268479

Regions

Nucleotide binding166 – 1683NADP By similarity

Sites

Binding site1911NADP By similarity
Binding site2321NADP; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RHV0 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 87E98A365290B10F

FASTA28330,267
        10         20         30         40         50         60 
MNNVIDGKAL ANEILSELKH EVQRLKDKTG ESPKLAIVLV GDNPASIIYV KNKIKHANKI 

        70         80         90        100        110        120 
GIDTLLLNLP ITIKTEDLIA KISELNLDQN VSGIIVQLPL PNSIDKNKIL SAISPSKDVD 

       130        140        150        160        170        180 
GFHPLNVGYL HSGIDNGFVP CTALGCLEVI KKHEPNLSGK NAIIVGRSNI VGKPLSALLL 

       190        200        210        220        230        240 
KENCSVTICH SKSQNLSSIT SKADIVVAAI GSPLKLTSGY FKPDAIVIDV GINRIGGNKI 

       250        260        270        280 
VGDVDFENVK SKVKYITPVP GGIGPMTIAF LLKNTVQAFK IYS 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05064.1.
RefSeqYP_538153.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RHV0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0983.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05064; ABE05064; RBE_0983.
GeneID3995125.
KEGGrbe:RBE_0983.
PATRIC17883509. VBIRicBel102610_1115.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHOG000218242.
KOK01491.
OMACTPYGIL.
OrthoDBEOG6K6VBB.
ProtClustDBPRK14171.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1008-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01576. THF_DHG_CYH.
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD_RICBR
AccessionPrimary (citable) accession number: Q1RHV0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways