Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1RHU4 (PYRG_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTP synthase

EC=6.3.4.2
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene names
Name:pyrG
Ordered Locus Names:RBE_0989
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP-Rule MF_01227

Catalytic activity

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate. HAMAP-Rule MF_01227

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP-Rule MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP-Rule MF_01227

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01227

Sequence similarities

Belongs to the CTP synthase family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' CTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

CTP synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540CTP synthase HAMAP-Rule MF_01227
PRO_0000266203

Regions

Domain290 – 539250Glutamine amidotransferase type-1
Region1 – 252252Aminator domain HAMAP-Rule MF_01227

Sites

Active site3791Nucleophile By similarity
Active site5121 By similarity
Active site5141 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RHU4 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 882E1E98DB6442CD

FASTA54060,883
        10         20         30         40         50         60 
MVRFIFITGG VVSSLGKGLT AASLAMLLQA KGFKVCLRKL DPYLNVDPGT MNPHQHGEVY 

        70         80         90        100        110        120 
VTDDGAETDL DLGHYERFTG VPACKFDNIT TGAVYSKLLK EERLGNYTGL TVQVIPHVTN 

       130        140        150        160        170        180 
IIKDFILSNT KGFDFVLCEI GGTVGDIEGL PFFEAIRQIG NELKSKQCLF IHLTLLPYVK 

       190        200        210        220        230        240 
TARELKTKPT QHSVKELRTI GISPNILVCR AERKIAKSEI EKIALFCNID PEYVIPAIDQ 

       250        260        270        280        290        300 
KNIYLVPLAY HDYGLDNKVL KFFNLTIAPS KLNRWHDIIE RLKESHSKVR IAIIAKYHKL 

       310        320        330        340        350        360 
KDAYKSVIEA LDHAGIYHKY KVDLVWINAE NVTNENISKK LLGVDGILVP GGFGERATEG 

       370        380        390        400        410        420 
KILAVNYART NNIPFFGICL GMQLAAIEIA RNLVGLKDAV TEEFKTAGTK IIERISKHDE 

       430        440        450        460        470        480 
DFNPSDITIE NIKKTMRLGS YTCNLVSDSI TANAYGELKI SERHRHRYKF NNDFQDIFEK 

       490        500        510        520        530        540 
NGVKFSGFSE DKKIVEAIEL PKLLWFVGVQ FHPEFKSKPF EAHPLFIRFV EAAIKYNKNN 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05070.1.
RefSeqYP_538159.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RHU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0989.

Proteomic databases

PRIDEQ1RHU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05070; ABE05070; RBE_0989.
GeneID3994958.
KEGGrbe:RBE_0989.
PATRIC17883525. VBIRicBel102610_1121.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0504.
HOGENOMHOG000077515.
KOK01937.
OMAYEFNNAY.
OrthoDBEOG6RC3NR.
ProtClustDBPRK05380.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1016-MONOMER.
UniPathwayUPA00159; UER00277.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_01227. PyrG.
InterProIPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11550. PTHR11550. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRG_RICBR
AccessionPrimary (citable) accession number: Q1RHU4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways