SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1RHU4

- PYRG_RICBR

UniProt

Q1RHU4 - PYRG_RICBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
CTP synthase
Gene
pyrG, RBE_0989
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei379 – 3791Nucleophile By similarity
Active sitei512 – 5121 By similarity
Active sitei514 – 5141 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. CTP synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1016-MONOMER.
UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase (EC:6.3.4.2)
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene namesi
Name:pyrG
Ordered Locus Names:RBE_0989
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540CTP synthaseUniRule annotation
PRO_0000266203Add
BLAST

Proteomic databases

PRIDEiQ1RHU4.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi336407.RBE_0989.

Structurei

3D structure databases

ProteinModelPortaliQ1RHU4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 539250Glutamine amidotransferase type-1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 252252Aminator domainUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the CTP synthase family.

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0504.
HOGENOMiHOG000077515.
KOiK01937.
OMAiSVNIKYI.
OrthoDBiEOG6RC3NR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RHU4-1 [UniParc]FASTAAdd to Basket

« Hide

MVRFIFITGG VVSSLGKGLT AASLAMLLQA KGFKVCLRKL DPYLNVDPGT    50
MNPHQHGEVY VTDDGAETDL DLGHYERFTG VPACKFDNIT TGAVYSKLLK 100
EERLGNYTGL TVQVIPHVTN IIKDFILSNT KGFDFVLCEI GGTVGDIEGL 150
PFFEAIRQIG NELKSKQCLF IHLTLLPYVK TARELKTKPT QHSVKELRTI 200
GISPNILVCR AERKIAKSEI EKIALFCNID PEYVIPAIDQ KNIYLVPLAY 250
HDYGLDNKVL KFFNLTIAPS KLNRWHDIIE RLKESHSKVR IAIIAKYHKL 300
KDAYKSVIEA LDHAGIYHKY KVDLVWINAE NVTNENISKK LLGVDGILVP 350
GGFGERATEG KILAVNYART NNIPFFGICL GMQLAAIEIA RNLVGLKDAV 400
TEEFKTAGTK IIERISKHDE DFNPSDITIE NIKKTMRLGS YTCNLVSDSI 450
TANAYGELKI SERHRHRYKF NNDFQDIFEK NGVKFSGFSE DKKIVEAIEL 500
PKLLWFVGVQ FHPEFKSKPF EAHPLFIRFV EAAIKYNKNN 540
Length:540
Mass (Da):60,883
Last modified:May 16, 2006 - v1
Checksum:i882E1E98DB6442CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05070.1.
RefSeqiWP_011477650.1. NC_007940.1.
YP_538159.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05070; ABE05070; RBE_0989.
GeneIDi3994958.
KEGGirbe:RBE_0989.
PATRICi17883525. VBIRicBel102610_1121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05070.1 .
RefSeqi WP_011477650.1. NC_007940.1.
YP_538159.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RHU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_0989.

Proteomic databases

PRIDEi Q1RHU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05070 ; ABE05070 ; RBE_0989 .
GeneIDi 3994958.
KEGGi rbe:RBE_0989.
PATRICi 17883525. VBIRicBel102610_1121.

Phylogenomic databases

eggNOGi COG0504.
HOGENOMi HOG000077515.
KOi K01937.
OMAi SVNIKYI.
OrthoDBi EOG6RC3NR.

Enzyme and pathway databases

UniPathwayi UPA00159 ; UER00277 .
BioCyci RBEL336407:GJCY-1016-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_01227. PyrG.
InterProi IPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11550. PTHR11550. 1 hit.
Pfami PF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00337. PyrG. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiPYRG_RICBR
AccessioniPrimary (citable) accession number: Q1RHU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi