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Q1RHU4

- PYRG_RICBR

UniProt

Q1RHU4 - PYRG_RICBR

Protein

CTP synthase

Gene

pyrG

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

    Catalytic activityi

    ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei379 – 3791NucleophileUniRule annotation
    Active sitei512 – 5121UniRule annotation
    Active sitei514 – 5141UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. CTP synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1016-MONOMER.
    UniPathwayiUPA00159; UER00277.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
    Alternative name(s):
    CTP synthetaseUniRule annotation
    UTP--ammonia ligaseUniRule annotation
    Gene namesi
    Name:pyrGUniRule annotation
    Ordered Locus Names:RBE_0989
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540CTP synthasePRO_0000266203Add
    BLAST

    Proteomic databases

    PRIDEiQ1RHU4.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RHU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 539250Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 252252Aminator domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CTP synthase family.UniRule annotation
    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0504.
    HOGENOMiHOG000077515.
    KOiK01937.
    OMAiSVNIKYI.
    OrthoDBiEOG6RC3NR.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_01227. PyrG.
    InterProiIPR029062. Class_I_gatase-like.
    IPR004468. CTP_synthase.
    IPR017456. CTP_synthase_N.
    IPR017926. GATASE.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11550. PTHR11550. 1 hit.
    PfamiPF06418. CTP_synth_N. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00337. PyrG. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RHU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRFIFITGG VVSSLGKGLT AASLAMLLQA KGFKVCLRKL DPYLNVDPGT    50
    MNPHQHGEVY VTDDGAETDL DLGHYERFTG VPACKFDNIT TGAVYSKLLK 100
    EERLGNYTGL TVQVIPHVTN IIKDFILSNT KGFDFVLCEI GGTVGDIEGL 150
    PFFEAIRQIG NELKSKQCLF IHLTLLPYVK TARELKTKPT QHSVKELRTI 200
    GISPNILVCR AERKIAKSEI EKIALFCNID PEYVIPAIDQ KNIYLVPLAY 250
    HDYGLDNKVL KFFNLTIAPS KLNRWHDIIE RLKESHSKVR IAIIAKYHKL 300
    KDAYKSVIEA LDHAGIYHKY KVDLVWINAE NVTNENISKK LLGVDGILVP 350
    GGFGERATEG KILAVNYART NNIPFFGICL GMQLAAIEIA RNLVGLKDAV 400
    TEEFKTAGTK IIERISKHDE DFNPSDITIE NIKKTMRLGS YTCNLVSDSI 450
    TANAYGELKI SERHRHRYKF NNDFQDIFEK NGVKFSGFSE DKKIVEAIEL 500
    PKLLWFVGVQ FHPEFKSKPF EAHPLFIRFV EAAIKYNKNN 540
    Length:540
    Mass (Da):60,883
    Last modified:May 16, 2006 - v1
    Checksum:i882E1E98DB6442CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05070.1.
    RefSeqiWP_011477650.1. NC_007940.1.
    YP_538159.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05070; ABE05070; RBE_0989.
    GeneIDi3994958.
    KEGGirbe:RBE_0989.
    PATRICi17883525. VBIRicBel102610_1121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05070.1 .
    RefSeqi WP_011477650.1. NC_007940.1.
    YP_538159.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RHU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0989.

    Proteomic databases

    PRIDEi Q1RHU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05070 ; ABE05070 ; RBE_0989 .
    GeneIDi 3994958.
    KEGGi rbe:RBE_0989.
    PATRICi 17883525. VBIRicBel102610_1121.

    Phylogenomic databases

    eggNOGi COG0504.
    HOGENOMi HOG000077515.
    KOi K01937.
    OMAi SVNIKYI.
    OrthoDBi EOG6RC3NR.

    Enzyme and pathway databases

    UniPathwayi UPA00159 ; UER00277 .
    BioCyci RBEL336407:GJCY-1016-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_01227. PyrG.
    InterProi IPR029062. Class_I_gatase-like.
    IPR004468. CTP_synthase.
    IPR017456. CTP_synthase_N.
    IPR017926. GATASE.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11550. PTHR11550. 1 hit.
    Pfami PF06418. CTP_synth_N. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00337. PyrG. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiPYRG_RICBR
    AccessioniPrimary (citable) accession number: Q1RHU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3