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Q1RHT9 (MURA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:RBE_0994
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_0000277899

Sites

Active site1191Proton donor By similarity

Amino acid modifications

Modified residue11912-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RHT9 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: D974E919BADC8256

FASTA41945,269
        10         20         30         40         50         60 
MQKLIIHGGK PLKGIINISG AKNAVLPIMA ASILTDKLHI TNVPKLTDVS TMKELLKSHG 

        70         80         90        100        110        120 
AGIEIIEHEN EFELVINAAN INNLTADYEI VRKMRASIWV LGPLLSRYGK AKVSLPGGCA 

       130        140        150        160        170        180 
IGARQVDLHI AVLKAMGAEI TIEDGYINAS TAGRLKGTHF IFDKISVGAT INAVLAAVLA 

       190        200        210        220        230        240 
DGETLLFNCA REPEIVDLCN CLNKMGADIS GIGTSEIRIN GKDSLSEASY RVLPDRIEAG 

       250        260        270        280        290        300 
TYMFAAAITK GDLKLYGIDY HIIENIALKL IETGIKVMPI DNGVQVTYAD KLNAVNLETN 

       310        320        330        340        350        360 
PYPGFATDLQ AQFMSLMTIS QGSSIITENI FENRFMHVPE LCRMGADITV RGNQAIVQGV 

       370        380        390        400        410 
KGLKGAEVMA SDLRASVSLI LAGLSTDSET VLHRIYHLDR GFQNLEKKLN NCGADIKRV 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05075.1.
RefSeqYP_538164.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RHT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0994.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05075; ABE05075; RBE_0994.
GeneID3994963.
KEGGrbe:RBE_0994.
PATRIC17883535. VBIRicBel102610_1126.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAHGLEQMG.
OrthoDBEOG68M4GK.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1021-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_RICBR
AccessionPrimary (citable) accession number: Q1RHT9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways