Q1RHT1 (XERD_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine recombinase XerD

Gene names

Name:	xerD
Ordered Locus Names:	RBE_1002

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity. HAMAP-Rule MF_01807
Subunit structure	Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 'phage' integrase family. XerD subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Tyrosine recombinase XerD HAMAP-Rule MF_01807		PRO_0000272368
Sites
	Active site	145	1	By similarity
	Active site	175	1	By similarity
	Active site	250	1	By similarity
	Active site	253	1	By similarity
	Active site	276	1	By similarity
	Active site	285	1	O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RHT1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: B98383395AFBC544	FASTA	305	34,689
	10 20 30 40 50 60 MEFISQFLEM LLAERALSKN SILSYKRDLL DFHNYLAKQK LSELNITTDN IRNWVEYLAE 70 80 90 100 110 120 NSLQARSINR KISTIKSYYE FLISENHTNL NPLLNIDLPK YQNKLPEILS IDDIKSLLEY 130 140 150 160 170 180 CSQDISPEGA RLNAMIHLLY ASGLRVSELV SLKLSDILSN KVSREVKKIF SVLGKGNKER 190 200 210 220 230 240 IIVINEPAIN SLVKYLVVRD NFVNKTKPKN LIYLFPSSAA AGYMTRQNFA ILLKSAALYA 250 260 270 280 290 300 GLNPEHISPH VLRHSFASHL LEGGADLRVI QELLGHADIS TTQIYTHLQT NHLKKALLHH PLSKN

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05083.1.
RefSeq	YP_538172.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RHT1.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_1002.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE05083; ABE05083; RBE_1002.
GeneID	3995364.
KEGG	rbe:RBE_1002.
PATRIC	17883555. VBIRicBel102610_1135.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4974.
HOGENOM	HOG000045296.
KO	K04763.
OMA	PEHISPH.
ProtClustDB	PRK00283.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-1030-MONOMER.
Family and domain databases
Gene3D	1.10.150.130. 1 hit. 1.10.443.10. 1 hit.
HAMAP	MF_01807. Recomb_XerD.
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core. IPR002104. Integrase_catalytic. IPR010998. Integrase_Lambda-type_N. IPR023109. Integrase_recombinase_N. IPR004107. Integrase_SAM-like_N. IPR011932. Recomb_XerD. IPR023009. Tyrosine_recombinase_XerC/XerD. [Graphical view]
Pfam	PF02899. Phage_integr_N. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
SUPFAM	SSF56349. DNA_brk_join_enz. 1 hit. SSF47823. L_intgrse_like_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

XERD_RICBR

Accession

Primary (citable) accession number: Q1RHT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program