Reviewed, UniProtKB/Swiss-Prot Q1RHJ0 (GLRX1_RICBR)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1

Gene names

Name:	grxC1
Synonyms:	grx
Ordered Locus Names:	RBE_1093

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	Glutaredoxin-1		PRO_0000288734
Regions
	Domain	1 – 98	98	Glutaredoxin
Amino acid modifications
	Disulfide bond	17 ↔ 20		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RHJ0-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: C8CD5CF1004CA730	FASTA	98	11,161
	10 20 30 40 50 60 MNKAILHAII IYTLAGCPYC MKAKALLDKK EVAYEEIEVQ NSQDPNVAVL RKKLNNPDRL 70 80 90 TFPQIFIDNM HIGGCDDLYD LDKEGRLDKL LEGQPKKD

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE05174.1.
RefSeq	YP_538263.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3995004.
GenomeReviews	Gene locus RBE_1093 in contig CP000087_GR.
KEGG	rbe:RBE_1093.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RHJ0.
OMA	Q1RHJ0. CDELHAL.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_1093-MON.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011900. GRX_bact. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02181. GRX_bact. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_RICBR

Accession

Primary (citable) accession number: Q1RHJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)