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Q1RHI9

- UVRB_RICBR

UniProt

Q1RHI9 - UVRB_RICBR

Protein

UvrABC system protein B

Gene

uvrB

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. excinuclease ABC activity Source: UniProtKB-HAMAP
    4. helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease, Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1127-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein BUniRule annotation
    Short name:
    Protein UvrBUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit BUniRule annotation
    Gene namesi
    Name:uvrBUniRule annotation
    Ordered Locus Names:RBE_1094
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 661661UvrABC system protein BPRO_0000277986Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_1094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RHI9.
    SMRiQ1RHI9. Positions 4-592.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 182158Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini430 – 592163Helicase C-terminalUniRule annotationAdd
    BLAST
    Domaini621 – 65636UVRUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi91 – 11424Beta-hairpinAdd
    BLAST

    Domaini

    The beta-hairpin motif is involved in DNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the UvrB family.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation
    Contains 1 UVR domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0556.
    HOGENOMiHOG000073580.
    KOiK03702.
    OMAiLEKQMHE.
    OrthoDBiEOG6B360R.

    Family and domain databases

    Gene3Di3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPiMF_00204. UvrB.
    InterProiIPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view]
    PANTHERiPTHR24029. PTHR24029. 1 hit.
    PfamiPF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00631. uvrb. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RHI9-1 [UniParc]FASTAAdd to Basket

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    MSNFSIISDY KPAGDQPKAI DEIIKGLNNK KRSQMLLGIT GSGKTFTMAN    50
    IIERTNRPTL IMAHNKTLAA QIYSEMKSIF PKNAVEYFVS YYDYYQPEAY 100
    IPKTDVFIEK DSSINEQIDL MRHSATRSLL ERRDVIVVSS VSCIYGLGSP 150
    DLYYQMTVNL EPGKSYPRDK LLNDLVNLQY ERNDIGFERG CFRVKGDNVD 200
    VFPSHYSDKA WRLSFFGNEL EYIHEFDPLT GEKLVKLDKA IIYGNSHFVM 250
    PKETVNKAIS EIEEELQKRI AFLKSQDKLL ETQRINQRTQ YDLEMLTETG 300
    SCKGVENYSR FFTGRKAGEP PPTLFEYLPK DALLFVDESH VSVPQIRAMY 350
    NGDRARKEVL VEHGFRLPSA LDNRPLKFEE WDNFRPQTVF VSATPSLFEL 400
    NETGGEVVEL IIRPTGLLDP ECIIKPATNQ VEDLVGEIQS TIAKGFCVLV 450
    TTLTKKMAED LTNYLQELKY KTSYLHSNIH TLERIEILRD LRQGTIDILV 500
    GINLLREGLD IPECGLVAIL DADKEGFLRS EVSLIQTIGR AARNSEGRVI 550
    LYADKMTKSI DKAISETMRR RTIQQEHNEK YGIIPKTINR TIHALAELEK 600
    VDSKLDKKQT HNLFENPAKL KAHIDKLRKE MLKAASNLEF EQAAKLRDQL 650
    KTLEEAALEL S 661
    Length:661
    Mass (Da):75,518
    Last modified:May 16, 2006 - v1
    Checksum:iD4446CCF7424E0AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05175.1.
    RefSeqiYP_538264.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05175; ABE05175; RBE_1094.
    GeneIDi3995005.
    KEGGirbe:RBE_1094.
    PATRICi17883765. VBIRicBel102610_1235.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05175.1 .
    RefSeqi YP_538264.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RHI9.
    SMRi Q1RHI9. Positions 4-592.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1094.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05175 ; ABE05175 ; RBE_1094 .
    GeneIDi 3995005.
    KEGGi rbe:RBE_1094.
    PATRICi 17883765. VBIRicBel102610_1235.

    Phylogenomic databases

    eggNOGi COG0556.
    HOGENOMi HOG000073580.
    KOi K03702.
    OMAi LEKQMHE.
    OrthoDBi EOG6B360R.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-1127-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPi MF_00204. UvrB.
    InterProi IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view ]
    PANTHERi PTHR24029. PTHR24029. 1 hit.
    Pfami PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00631. uvrb. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiUVRB_RICBR
    AccessioniPrimary (citable) accession number: Q1RHI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3