ID   PTPS_RICBR              Reviewed;         138 AA.
AC   Q1RHI6;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Putative 6-pyruvoyl tetrahydrobiopterin synthase;
DE            Short=PTP synthase;
DE            Short=PTPS;
DE            EC=4.2.3.12;
GN   OrderedLocusNames=RBE_1097;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- CATALYTIC ACTIVITY: 7,8-dihydroneopterin 3'-triphosphate = 6-
CC       pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis;
CC       tetrahydrobiopterin from 2-amino-4-hydroxy-6-(erythro-1,2,3-
CC       trihydroxypropyl)-dihydropteridine triphosphate: step 1/3.
CC   -!- SUBUNIT: Homohexamer formed of two homotrimers in a head to head
CC       fashion (By similarity).
CC   -!- MISCELLANEOUS: The active site is at the interface between 2
CC       subunits. The proton acceptor Cys is on one subunit, and the
CC       charge relay system is on the other subunit.
CC   -!- SIMILARITY: Belongs to the PTPS family.
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DR   EMBL; CP000087; ABE05178.1; -; Genomic_DNA.
DR   RefSeq; YP_538267.1; -.
DR   GeneID; 3995008; -.
DR   GenomeReviews; CP000087_GR; RBE_1097.
DR   KEGG; rbe:RBE_1097; -.
DR   HOGENOM; Q1RHI6; -.
DR   OMA; Q1RHI6; GHKTVVL.
DR   BioCyc; RBEL336407:RBE_1097-MON; -.
DR   GO; GO:0003874; F:6-pyruvoyltetrahydropterin synthase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR007115; 6-PTP_synth-rel.
DR   PANTHER; PTHR12589; 6_PTP_synth; 1.
DR   ProDom; PD004049; PTPS_hypoth; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Lyase; Metal-binding;
KW   Tetrahydrobiopterin biosynthesis; Zinc.
FT   CHAIN         1    138       Putative 6-pyruvoyl tetrahydrobiopterin
FT                                synthase.
FT                                /FTId=PRO_0000272629.
FT   ACT_SITE     23     23       Proton acceptor (By similarity).
FT   ACT_SITE     68     68       Charge relay system (By similarity).
FT   ACT_SITE    130    130       Charge relay system (By similarity).
FT   METAL        14     14       Zinc (By similarity).
FT   METAL        27     27       Zinc (By similarity).
FT   METAL        29     29       Zinc (By similarity).
SQ   SEQUENCE   138 AA;  15985 MW;  4E19F7E941A9FB50 CRC64;
     MIKCTRRIEF DAGHRIIGHQ NKCQYLHGHR YVLEITIAAK NTDELGMVVD FGLIKDLAKG
     WVDENFDHSL ILHQGDKEIG QKIESHTGQK VYYLKNNPTA ENIALHLKNE IFPKLFESQK
     FFVTNIKLFE TPNCFVEV
//