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Q1RHI6 (QUED_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase

Short name=CPH4 synthase
EC=4.1.2.50
Alternative name(s):
Queuosine biosynthesis protein QueD
Gene names
Name:queD
Ordered Locus Names:RBE_1097
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde By similarity.

Catalytic activity

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit By similarity.

Sequence similarities

Belongs to the PTPS family. QueD subfamily.

Ontologies

Keywords
   Biological processQueuosine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processqueuosine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlyase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1381386-carboxy-5,6,7,8-tetrahydropterin synthase
PRO_0000272629

Sites

Active site231Proton acceptor By similarity
Active site681Charge relay system By similarity
Active site1301Charge relay system By similarity
Metal binding141Zinc By similarity
Metal binding271Zinc By similarity
Metal binding291Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RHI6 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 4E19F7E941A9FB50

FASTA13815,985
        10         20         30         40         50         60 
MIKCTRRIEF DAGHRIIGHQ NKCQYLHGHR YVLEITIAAK NTDELGMVVD FGLIKDLAKG 

        70         80         90        100        110        120 
WVDENFDHSL ILHQGDKEIG QKIESHTGQK VYYLKNNPTA ENIALHLKNE IFPKLFESQK 

       130 
FFVTNIKLFE TPNCFVEV 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05178.1.
RefSeqYP_538267.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RHI6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_1097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05178; ABE05178; RBE_1097.
GeneID3995008.
KEGGrbe:RBE_1097.
PATRIC17883771. VBIRicBel102610_1238.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0720.
HOGENOMHOG000225068.
KOK01737.
OMAWASEIAR.
OrthoDBEOG6FFSCJ.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1130-MONOMER.
UniPathwayUPA00391.

Family and domain databases

InterProIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERPTHR12589. PTHR12589. 1 hit.
PfamPF01242. PTPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQUED_RICBR
AccessionPrimary (citable) accession number: Q1RHI6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways