Q1RHI6 (QUED_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase
Short name=CPH4 synthase
EC=4.1.2.50

Alternative name(s):
Queuosine biosynthesis protein QueD

Gene names

Name:	queD
Ordered Locus Names:	RBE_1097

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde By similarity.
Catalytic activity	7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
Miscellaneous	The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit By similarity.
Sequence similarities	Belongs to the PTPS family. QueD subfamily.

Ontologies

Keywords
Biological process	Queuosine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	queuosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lyase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	6-carboxy-5,6,7,8-tetrahydropterin synthase		PRO_0000272629
Sites
	Active site	23	1	Proton acceptor By similarity
	Active site	68	1	Charge relay system By similarity
	Active site	130	1	Charge relay system By similarity
	Metal binding	14	1	Zinc By similarity
	Metal binding	27	1	Zinc By similarity
	Metal binding	29	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RHI6 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 4E19F7E941A9FB50	FASTA	138	15,985
	10 20 30 40 50 60 MIKCTRRIEF DAGHRIIGHQ NKCQYLHGHR YVLEITIAAK NTDELGMVVD FGLIKDLAKG 70 80 90 100 110 120 WVDENFDHSL ILHQGDKEIG QKIESHTGQK VYYLKNNPTA ENIALHLKNE IFPKLFESQK 130 FFVTNIKLFE TPNCFVEV

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05178.1.
RefSeq	YP_538267.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RHI6.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_1097.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE05178; ABE05178; RBE_1097.
GeneID	3995008.
KEGG	rbe:RBE_1097.
PATRIC	17883771. VBIRicBel102610_1238.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0720.
HOGENOM	HOG000225068.
KO	K01737.
OMA	GHKTVVL.
ProtClustDB	CLSK870781.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-1130-MONOMER.
UniPathway	UPA00391.
Family and domain databases
InterPro	IPR007115. 6-PTP_synth/QueD. [Graphical view]
PANTHER	PTHR12589. PTHR12589. 1 hit.
Pfam	PF01242. PTPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QUED_RICBR

Accession

Primary (citable) accession number: Q1RHI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program