Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-carboxy-5,6,7,8-tetrahydropterin synthase

Gene

queD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.By similarity

Catalytic activityi

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141ZincBy similarity
Active sitei23 – 231Proton acceptorBy similarity
Metal bindingi27 – 271ZincBy similarity
Metal bindingi29 – 291ZincBy similarity
Active sitei68 – 681Charge relay systemBy similarity
Active sitei130 – 1301Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1130-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase (EC:4.1.2.50)
Short name:
CPH4 synthase
Alternative name(s):
Queuosine biosynthesis protein QueD
Gene namesi
Name:queD
Ordered Locus Names:RBE_1097
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1381386-carboxy-5,6,7,8-tetrahydropterin synthasePRO_0000272629Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1RHI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPS family. QueD subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000225068.
KOiK01737.
OMAiTPNCWAE.
OrthoDBiPOG091H01RY.

Family and domain databases

InterProiIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERiPTHR12589. PTHR12589. 1 hit.
PfamiPF01242. PTPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RHI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKCTRRIEF DAGHRIIGHQ NKCQYLHGHR YVLEITIAAK NTDELGMVVD
60 70 80 90 100
FGLIKDLAKG WVDENFDHSL ILHQGDKEIG QKIESHTGQK VYYLKNNPTA
110 120 130
ENIALHLKNE IFPKLFESQK FFVTNIKLFE TPNCFVEV
Length:138
Mass (Da):15,985
Last modified:May 16, 2006 - v1
Checksum:i4E19F7E941A9FB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05178.1.
RefSeqiWP_011477756.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05178; ABE05178; RBE_1097.
KEGGirbe:RBE_1097.
PATRICi17883771. VBIRicBel102610_1238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05178.1.
RefSeqiWP_011477756.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RHI6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE05178; ABE05178; RBE_1097.
KEGGirbe:RBE_1097.
PATRICi17883771. VBIRicBel102610_1238.

Phylogenomic databases

HOGENOMiHOG000225068.
KOiK01737.
OMAiTPNCWAE.
OrthoDBiPOG091H01RY.

Enzyme and pathway databases

UniPathwayiUPA00391.
BioCyciRBEL336407:GJCY-1130-MONOMER.

Family and domain databases

InterProiIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERiPTHR12589. PTHR12589. 1 hit.
PfamiPF01242. PTPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQUED_RICBR
AccessioniPrimary (citable) accession number: Q1RHI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).By similarity

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.