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Reviewed, UniProtKB/Swiss-Prot Q1RHI6 (PTPS_RICBR)

Last modified June 16, 2009. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative 6-pyruvoyl tetrahydrobiopterin synthase
      Short name=PTP synthase
      Short name=PTPS
    EC=4.2.3.12
Gene names
Ordered Locus Names: RBE_1097
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

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Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate: step 1/3.

Subunit structure

Homohexamer formed of two homotrimers in a head to head fashion By similarity.

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.

Sequence similarities

Belongs to the PTPS family.

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Ontologies

Keywords
   Biological processTetrahydrobiopterin biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtetrahydrobiopterin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function6-pyruvoyltetrahydropterin synthase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Putative 6-pyruvoyl tetrahydrobiopterin synthase
PRO_0000272629

Sites

Active site231Proton acceptor By similarity
Active site681Charge relay system By similarity
Active site1301Charge relay system By similarity
Metal binding141Zinc By similarity
Metal binding271Zinc By similarity
Metal binding291Zinc By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q1RHI6-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 4E19F7E941A9FB50

FASTA13815,985
        10         20         30         40         50         60 
MIKCTRRIEF DAGHRIIGHQ NKCQYLHGHR YVLEITIAAK NTDELGMVVD FGLIKDLAKG 

        70         80         90        100        110        120 
WVDENFDHSL ILHQGDKEIG QKIESHTGQK VYYLKNNPTA ENIALHLKNE IFPKLFESQK 

       130 
FFVTNIKLFE TPNCFVEV

« Hide

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References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000087 Genomic DNA. Translation: ABE05178.1.
RefSeqYP_538267.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3995008.
GenomeReviewsGene locus RBE_1097 in contig CP000087_GR.
KEGGrbe:RBE_1097.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1RHI6.
OMAQ1RHI6. GHKTVVL.

Enzyme and pathway databases

BioCycRBEL336407:RBE_1097-MON.

Family and domain databases

InterProIPR007115. 6-PTP_synth-rel.
[Graphical view]
PANTHERPTHR12589. 6_PTP_synth. 1 hit.
ProDomPD004049. PTPS_hypoth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

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Entry information

Entry namePTPS_RICBR
AccessionPrimary (citable) accession number: Q1RHI6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents