Reviewed,
UniProtKB/Swiss-Prot Q1RHI6 (PTPS_RICBR)
Last modified
June 16, 2009.
Version 23.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative 6-pyruvoyl tetrahydrobiopterin synthase Short name=PTP synthase Short name=PTPS EC=4.2.3.12 | ||
| Gene names |
| ||
| Organism | Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP] | ||
| Taxonomic identifier | 336407 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia |
Protein attributes
| Sequence length | 138 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subunit structure | Homohexamer formed of two homotrimers in a head to head fashion By similarity. |
| Miscellaneous | The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit. |
| Sequence similarities | Belongs to the PTPS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tetrahydrobiopterin biosynthesis |
| Ligand | Metal-binding Zinc |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 6-pyruvoyltetrahydropterin synthase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 138 | 138 | Putative 6-pyruvoyl tetrahydrobiopterin synthase | PRO_0000272629 | |||||
Sites | |||||||||
| Active site | 23 | 1 | Proton acceptor By similarity | ||||||
| Active site | 68 | 1 | Charge relay system By similarity | ||||||
| Active site | 130 | 1 | Charge relay system By similarity | ||||||
| Metal binding | 14 | 1 | Zinc By similarity | ||||||
| Metal binding | 27 | 1 | Zinc By similarity | ||||||
| Metal binding | 29 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000087 Genomic DNA. Translation: ABE05178.1. | |
| RefSeq | YP_538267.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3995008. |
| GenomeReviews | Gene locus RBE_1097 in contig CP000087_GR. |
| KEGG | rbe:RBE_1097. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q1RHI6. |
| OMA | Q1RHI6. GHKTVVL. |
Enzyme and pathway databases | |
| BioCyc | RBEL336407:RBE_1097-MON. |
Family and domain databases | |
| InterPro | IPR007115. 6-PTP_synth-rel. [Graphical view] |
| PANTHER | PTHR12589. 6_PTP_synth. 1 hit. |
| ProDom | PD004049. PTPS_hypoth. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | PTPS_RICBR | ||||||||
| Accession | Primary (citable) accession number: Q1RHI6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Rickettsia bellii strain RML369-C Rickettsia bellii (strain RML369-C): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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