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Q1RHI6

- QUED_RICBR

UniProt

Q1RHI6 - QUED_RICBR

Protein

6-carboxy-5,6,7,8-tetrahydropterin synthase

Gene

queD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.By similarity

    Catalytic activityi

    7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi14 – 141ZincBy similarity
    Active sitei23 – 231Proton acceptorBy similarity
    Metal bindingi27 – 271ZincBy similarity
    Metal bindingi29 – 291ZincBy similarity
    Active sitei68 – 681Charge relay systemBy similarity
    Active sitei130 – 1301Charge relay systemBy similarity

    GO - Molecular functioni

    1. lyase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1130-MONOMER.
    UniPathwayiUPA00391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-carboxy-5,6,7,8-tetrahydropterin synthase (EC:4.1.2.50)
    Short name:
    CPH4 synthase
    Alternative name(s):
    Queuosine biosynthesis protein QueD
    Gene namesi
    Name:queD
    Ordered Locus Names:RBE_1097
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1381386-carboxy-5,6,7,8-tetrahydropterin synthasePRO_0000272629Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_1097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RHI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PTPS family. QueD subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0720.
    HOGENOMiHOG000225068.
    KOiK01737.
    OMAiWASEIAR.
    OrthoDBiEOG6FFSCJ.

    Family and domain databases

    InterProiIPR007115. 6-PTP_synth/QueD.
    [Graphical view]
    PANTHERiPTHR12589. PTHR12589. 1 hit.
    PfamiPF01242. PTPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RHI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKCTRRIEF DAGHRIIGHQ NKCQYLHGHR YVLEITIAAK NTDELGMVVD    50
    FGLIKDLAKG WVDENFDHSL ILHQGDKEIG QKIESHTGQK VYYLKNNPTA 100
    ENIALHLKNE IFPKLFESQK FFVTNIKLFE TPNCFVEV 138
    Length:138
    Mass (Da):15,985
    Last modified:May 16, 2006 - v1
    Checksum:i4E19F7E941A9FB50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05178.1.
    RefSeqiYP_538267.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05178; ABE05178; RBE_1097.
    GeneIDi3995008.
    KEGGirbe:RBE_1097.
    PATRICi17883771. VBIRicBel102610_1238.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05178.1 .
    RefSeqi YP_538267.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RHI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05178 ; ABE05178 ; RBE_1097 .
    GeneIDi 3995008.
    KEGGi rbe:RBE_1097.
    PATRICi 17883771. VBIRicBel102610_1238.

    Phylogenomic databases

    eggNOGi COG0720.
    HOGENOMi HOG000225068.
    KOi K01737.
    OMAi WASEIAR.
    OrthoDBi EOG6FFSCJ.

    Enzyme and pathway databases

    UniPathwayi UPA00391 .
    BioCyci RBEL336407:GJCY-1130-MONOMER.

    Family and domain databases

    InterProi IPR007115. 6-PTP_synth/QueD.
    [Graphical view ]
    PANTHERi PTHR12589. PTHR12589. 1 hit.
    Pfami PF01242. PTPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiQUED_RICBR
    AccessioniPrimary (citable) accession number: Q1RHI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit By similarity.By similarity

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3