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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RBE_1099
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9279272-oxoglutarate dehydrogenase E1 componentPRO_0000288749Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi336407.RBE_1099.

Structurei

3D structure databases

ProteinModelPortaliQ1RHI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RHI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEENLKKTGF LFGGNAVFIE ELYKQYLENP ASVDQTWQEF FSSVKDSNQL
60 70 80 90 100
LNKSTAKIIL KAAATEESKT SENPVSTTNN FNVGAMIKNY RKYAHYLAKL
110 120 130 140 150
DPLGLEVTKT KEDLKLSIEN FGFTNDQLSK VIEHKFLEKT YNLGELVNFL
160 170 180 190 200
DKTYAGSIGV EFEQVENEEE KNWLYSKLES GVISFSSEEK KNILNDLVEV
210 220 230 240 250
EGFEQYLHTK FPGAKRFSVE GGDASIVAMN KAIDLSLHQG VEEIVIGMAH
260 270 280 290 300
RGRLNTLTKV VGKPYRAVIA GFISGSVFPD ELNVSGDVKY HLGYSSDRVV
310 320 330 340 350
GDKKIHLSLA DNPSHLEAVN PIFAGKVRAK QDMLKDNKRS KVKAILVHGD
360 370 380 390 400
AAFCGQGVVA ESLSMSPLAA YNIGGVLHFV INNQLGFTAN AADTRASRYS
410 420 430 440 450
TEFAKIIAVP ILHVNGDDIE AVLKATNIAV EYRQKFGKDV IVEIICYRKY
460 470 480 490 500
GHNEGDEPMY TQGKMYNIIK SKLTPGNIYA NELVKSGVID NNYFAKLKEQ
510 520 530 540 550
FKAKLDKEYE QAKNYKQEAH FLGGLWQGIT RTRTQVAVTG VDKKTLQSLG
560 570 580 590 600
TKLCEMPKDF AVNPKLVKLF DARKAALTAD QPIDWATAEQ LAFASLLTSG
610 620 630 640 650
TNIRLTGQDC GRGTFSHRHS VLHNQVDDTT YIPLNNLSKE QATYEVADSN
660 670 680 690 700
LSEYAVLGFE YGYSLANPKN LVLWEAQFGD FANGAQIIFD QFISSSETKW
710 720 730 740 750
LRMSGLVVLL PHGFEGQGPE HSSARLERFL QLAAEDNMYV TYPTTPASIF
760 770 780 790 800
HLLRRQIIDN VRKPLIVMSP KSLLRHKNVV SKLDELGSNT TFLPVLDEVN
810 820 830 840 850
KLEASNITKV ILCSGKVYYD LFEMRGSNSS IAIIRLEQLY PFEKKVVVEL
860 870 880 890 900
LKKYNKASEF IWCQEEPMNM GAWRYITSHL NNALKEAGIN NEFKYIGREE
910 920
SASPAVGSLQ AHNKQQEKLL KEALGVK
Length:927
Mass (Da):103,677
Last modified:May 15, 2006 - v1
Checksum:iAAD6B2E0CEF8304E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05180.1.
RefSeqiYP_538269.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05180; ABE05180; RBE_1099.
KEGGirbe:RBE_1099.
PATRICi17883775. VBIRicBel102610_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05180.1.
RefSeqiYP_538269.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RHI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336407.RBE_1099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE05180; ABE05180; RBE_1099.
KEGGirbe:RBE_1099.
PATRICi17883775. VBIRicBel102610_1240.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1132-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiODO1_RICBR
AccessioniPrimary (citable) accession number: Q1RHI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 28, 2007
Last sequence update: May 15, 2006
Last modified: March 31, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.