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Q1RHI4

- ODO1_RICBR

UniProt

Q1RHI4 - ODO1_RICBR

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
sucA, RBE_1099
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RBE_1099
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9279272-oxoglutarate dehydrogenase E1 component
PRO_0000288749Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi336407.RBE_1099.

Structurei

3D structure databases

ProteinModelPortaliQ1RHI4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RHI4-1 [UniParc]FASTAAdd to Basket

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MEENLKKTGF LFGGNAVFIE ELYKQYLENP ASVDQTWQEF FSSVKDSNQL    50
LNKSTAKIIL KAAATEESKT SENPVSTTNN FNVGAMIKNY RKYAHYLAKL 100
DPLGLEVTKT KEDLKLSIEN FGFTNDQLSK VIEHKFLEKT YNLGELVNFL 150
DKTYAGSIGV EFEQVENEEE KNWLYSKLES GVISFSSEEK KNILNDLVEV 200
EGFEQYLHTK FPGAKRFSVE GGDASIVAMN KAIDLSLHQG VEEIVIGMAH 250
RGRLNTLTKV VGKPYRAVIA GFISGSVFPD ELNVSGDVKY HLGYSSDRVV 300
GDKKIHLSLA DNPSHLEAVN PIFAGKVRAK QDMLKDNKRS KVKAILVHGD 350
AAFCGQGVVA ESLSMSPLAA YNIGGVLHFV INNQLGFTAN AADTRASRYS 400
TEFAKIIAVP ILHVNGDDIE AVLKATNIAV EYRQKFGKDV IVEIICYRKY 450
GHNEGDEPMY TQGKMYNIIK SKLTPGNIYA NELVKSGVID NNYFAKLKEQ 500
FKAKLDKEYE QAKNYKQEAH FLGGLWQGIT RTRTQVAVTG VDKKTLQSLG 550
TKLCEMPKDF AVNPKLVKLF DARKAALTAD QPIDWATAEQ LAFASLLTSG 600
TNIRLTGQDC GRGTFSHRHS VLHNQVDDTT YIPLNNLSKE QATYEVADSN 650
LSEYAVLGFE YGYSLANPKN LVLWEAQFGD FANGAQIIFD QFISSSETKW 700
LRMSGLVVLL PHGFEGQGPE HSSARLERFL QLAAEDNMYV TYPTTPASIF 750
HLLRRQIIDN VRKPLIVMSP KSLLRHKNVV SKLDELGSNT TFLPVLDEVN 800
KLEASNITKV ILCSGKVYYD LFEMRGSNSS IAIIRLEQLY PFEKKVVVEL 850
LKKYNKASEF IWCQEEPMNM GAWRYITSHL NNALKEAGIN NEFKYIGREE 900
SASPAVGSLQ AHNKQQEKLL KEALGVK 927
Length:927
Mass (Da):103,677
Last modified:May 16, 2006 - v1
Checksum:iAAD6B2E0CEF8304E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05180.1.
RefSeqiYP_538269.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05180; ABE05180; RBE_1099.
GeneIDi3995010.
KEGGirbe:RBE_1099.
PATRICi17883775. VBIRicBel102610_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05180.1 .
RefSeqi YP_538269.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RHI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05180 ; ABE05180 ; RBE_1099 .
GeneIDi 3995010.
KEGGi rbe:RBE_1099.
PATRICi 17883775. VBIRicBel102610_1240.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-1132-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiODO1_RICBR
AccessioniPrimary (citable) accession number: Q1RHI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 16, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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