Q1RHI4 (ODO1_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	sucA
Ordered Locus Names:	RBE_1099

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	927 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 927	927	2-oxoglutarate dehydrogenase E1 component		PRO_0000288749

Sequences

	Sequence		Length	Mass (Da)
	Q1RHI4 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: AAD6B2E0CEF8304E	FASTA	927	103,677
	10 20 30 40 50 60 MEENLKKTGF LFGGNAVFIE ELYKQYLENP ASVDQTWQEF FSSVKDSNQL LNKSTAKIIL 70 80 90 100 110 120 KAAATEESKT SENPVSTTNN FNVGAMIKNY RKYAHYLAKL DPLGLEVTKT KEDLKLSIEN 130 140 150 160 170 180 FGFTNDQLSK VIEHKFLEKT YNLGELVNFL DKTYAGSIGV EFEQVENEEE KNWLYSKLES 190 200 210 220 230 240 GVISFSSEEK KNILNDLVEV EGFEQYLHTK FPGAKRFSVE GGDASIVAMN KAIDLSLHQG 250 260 270 280 290 300 VEEIVIGMAH RGRLNTLTKV VGKPYRAVIA GFISGSVFPD ELNVSGDVKY HLGYSSDRVV 310 320 330 340 350 360 GDKKIHLSLA DNPSHLEAVN PIFAGKVRAK QDMLKDNKRS KVKAILVHGD AAFCGQGVVA 370 380 390 400 410 420 ESLSMSPLAA YNIGGVLHFV INNQLGFTAN AADTRASRYS TEFAKIIAVP ILHVNGDDIE 430 440 450 460 470 480 AVLKATNIAV EYRQKFGKDV IVEIICYRKY GHNEGDEPMY TQGKMYNIIK SKLTPGNIYA 490 500 510 520 530 540 NELVKSGVID NNYFAKLKEQ FKAKLDKEYE QAKNYKQEAH FLGGLWQGIT RTRTQVAVTG 550 560 570 580 590 600 VDKKTLQSLG TKLCEMPKDF AVNPKLVKLF DARKAALTAD QPIDWATAEQ LAFASLLTSG 610 620 630 640 650 660 TNIRLTGQDC GRGTFSHRHS VLHNQVDDTT YIPLNNLSKE QATYEVADSN LSEYAVLGFE 670 680 690 700 710 720 YGYSLANPKN LVLWEAQFGD FANGAQIIFD QFISSSETKW LRMSGLVVLL PHGFEGQGPE 730 740 750 760 770 780 HSSARLERFL QLAAEDNMYV TYPTTPASIF HLLRRQIIDN VRKPLIVMSP KSLLRHKNVV 790 800 810 820 830 840 SKLDELGSNT TFLPVLDEVN KLEASNITKV ILCSGKVYYD LFEMRGSNSS IAIIRLEQLY 850 860 870 880 890 900 PFEKKVVVEL LKKYNKASEF IWCQEEPMNM GAWRYITSHL NNALKEAGIN NEFKYIGREE 910 920 SASPAVGSLQ AHNKQQEKLL KEALGVK

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05180.1.
RefSeq	YP_538269.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RHI4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RHI4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995010.
GenomeReviews	Gene locus RBE_1099 in contig CP000087_GR.
KEGG	rbe:RBE_1099.
PATRIC	17883775. VBIRicBel102610_1240.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HBG289950.
OMA	EGDEPAF.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_1099-MONOMER.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
KO	K00164.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_RICBR

Accession

Primary (citable) accession number: Q1RHI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program