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Q1RHD0 (RPOB_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta

Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:RBE_1153
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length1372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. HAMAP-Rule MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13721372DNA-directed RNA polymerase subunit beta HAMAP-Rule MF_01321
PRO_0000272393

Sequences

Sequence LengthMass (Da)Tools
Q1RHD0 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 72431578B8F20B58

FASTA1,372153,845
        10         20         30         40         50         60 
MVSLRDNIEV QPLSHNKRVR KNFGHINLVA DIPNLIEIQK NSYEKNFLQL DTKDSERKNK 

        70         80         90        100        110        120 
GLQSILNSIF PISDPSNIAN LEFVKYEFDT PKYDVEECTQ RSLSYDSALK VTLRLSIWDI 

       130        140        150        160        170        180 
DEDTGSREIK GIKEQQVYMG NIPLMTKNGT FIINGTERVV VSQMHRSPGV FFYHDEGKVH 

       190        200        210        220        230        240 
SSRKLLYSAR VIPYRGSWLD LEFDAKDIIY FRIDRKRKLY ATTLLKAIGM STEEIIKFYY 

       250        260        270        280        290        300 
DSVNYKVVKN KGWAVKFMPS HITAHRLTSD LIDADTGNVL LKAGQKITPR LAKKYAGEGL 

       310        320        330        340        350        360 
NNILVSHKAL IGKYLSEDLK DPESDEILAK IGEMITVELL SVISDLKIKN ISVLVINPQS 

       370        380        390        400        410        420 
GPYIRNTLFS DKNQDRESAL FDIFRVLRPG EPANIEAAES LFYNLFFDPE RYDLSEVGRI 

       430        440        450        460        470        480 
KMNSRLELNI SDETTVLTTD DIKNILRVLV ELKDRKGIID DIDHLGNRRV RSVGELIENQ 

       490        500        510        520        530        540 
FRIGLVRMEK SVVERMSAGD IDTVMPHDLV NSKILVSVVK EFFSTSQLSQ FMDQTNPLSE 

       550        560        570        580        590        600 
ITHKRRLSAL GPGGLSRDRA GFEVRDVHPT HYGRICPIET PEGQNIGLIN SMATYARINK 

       610        620        630        640        650        660 
HGFIESPYRK VKDGHVTDEV VYLSAIEEGK YKIGQANSKV DKDGILQGEF INCRVEGGNF 

       670        680        690        700        710        720 
VMVEPHEVDF IDVTPMQVVS VAASLIPFLE NDDANRALMG SNMQRQAVPL IKTDAPFVGT 

       730        740        750        760        770        780 
GVEGVVAKDS GASVLALNDG IVEQVDSNRI VIRAIAQKTE SAPSVDIYNL LKFQKSNHNT 

       790        800        810        820        830        840 
CINQKPLVKV GHYVKKNDII ADGPSTDNGE IALGRNVLVA FLPWNGYNFE DSILISERIV 

       850        860        870        880        890        900 
KEDVFTSVHI EEFEVIARDT RLGPEEITRD IPNVSEEALR HLDEVGIIYV GAEVKAGDIL 

       910        920        930        940        950        960 
VGKVTPKSES PITPEEKLLR AIFGEKAFDV KDSSLHVPSG VSGTVVEVRV FSRRGVEKDQ 

       970        980        990       1000       1010       1020 
RAIAIEKQQI EKLAKDRDDE LEIIEHFVFS WLEKLLVGQV SINGPKTVKT GQTITSEILK 

      1030       1040       1050       1060       1070       1080 
GLSKGQLWQF TVEDANVMNE IEQLKGHYDG KKEALNKRFA TKVEKLQSGD DLPQGALKVV 

      1090       1100       1110       1120       1130       1140 
KVFIATKHKL QPGDKMAGRH GNKGVISRIV PEEDMPFLED GTVVDIVLNP LGLPSRMNIG 

      1150       1160       1170       1180       1190       1200 
QVLETHLGWA SVNLAKKIAG LVEEHKTKHA SIEKIKKFLI ELYGENINHI LEKSDEEIIS 

      1210       1220       1230       1240       1250       1260 
FCNEAAKGVY FATPVFDGAK VEDVKDMLRL AGQDLSGQVK LIDGRTGEYF DRLVTVGQKY 

      1270       1280       1290       1300       1310       1320 
LLKLHHLVDN KIHSRSIGPY SLVTQQPLGG KSHFGGQRFG EMECWALQAY GAAYTLQEML 

      1330       1340       1350       1360       1370 
TVKSDDVNGR IKIYDSIVRG ENNFESGIPE SFNVMIKEFR SLCLNVKLEV TS 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05234.1.
RefSeqYP_538323.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RHD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_1153.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05234; ABE05234; RBE_1153.
GeneID3995110.
KEGGrbe:RBE_1153.
PATRIC17883903. VBIRicBel102610_1303.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0085.
HOGENOMHOG000218612.
KOK03043.
OMANPKRYDL.
OrthoDBEOG6M9DS6.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1187-MONOMER.

Family and domain databases

Gene3D2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPMF_01321. RNApol_bact_RpoB.
InterProIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERPTHR20856. PTHR20856. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. rpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_RICBR
AccessionPrimary (citable) accession number: Q1RHD0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names