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Q1RHB9

- SDHA_RICBR

UniProt

Q1RHB9 - SDHA_RICBR

Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei225 – 2251FADBy similarity
    Binding sitei246 – 2461SubstrateBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei290 – 2901Proton acceptorBy similarity
    Binding sitei357 – 3571SubstrateBy similarity
    Binding sitei391 – 3911FADBy similarity
    Binding sitei402 – 4021SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 236FADBy similarity
    Nucleotide bindingi41 – 5616FADBy similarityAdd
    BLAST
    Nucleotide bindingi407 – 4082FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1199-MONOMER.
    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhA
    Ordered Locus Names:RBE_1164
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596Succinate dehydrogenase flavoprotein subunitPRO_0000280976Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491Tele-8alpha-FAD histidineBy similarity

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Protein-protein interaction databases

    STRINGi336407.RBE_1164.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RHB9.
    SMRiQ1RHB9. Positions 5-596.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1053.
    HOGENOMiHOG000160475.
    KOiK00239.
    OMAiSYRPVHV.
    OrthoDBiEOG6M3PC4.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RHB9-1 [UniParc]FASTAAdd to Basket

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    MTKSYNIIHH KFDVIVVGAG GAGLRAAFGM AEEGLNTACI SKLFPTRSHT    50
    VAAQGGISAA LGNMGADDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI 100
    LELEHYGVPF SRTEEGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI 150
    LHTLYQQSLK HKVQFFIEYF AIDLLMENGE CRGVVAWNLD DGSLHCFRAH 200
    NVVLATGGYG RAYFSATSAH TCTGDGGGMA IRAGLPLQDM EFVQFHPTGI 250
    YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 300
    IREGRGVGEH KDHVFLHLNH LSPEIVHSRL PGISETAKIF AGVDVTKEPI 350
    PVLPTVHYNM GGIPTNYHGQ VIIKDGKNHN SVVKGLMSIG EAACVSVHGA 400
    NRLGSNSLLD LVVFGRSAAL KAAELIKPAS PHKPVSEEAL EKIISRFDKI 450
    RHSSGNISVA DLRLKMQRTM QSHASVFRTQ EVLDEGAEMI SEIRSGYKDI 500
    KVNDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR GAHAREDYPD 550
    RNDKEWMQHT LSGVDEAGKV VLDYKPVTLT TLSDEVKAIP PAKRVY 596
    Length:596
    Mass (Da):65,106
    Last modified:May 16, 2006 - v1
    Checksum:iF3A2C76895400AF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05245.1.
    RefSeqiYP_538334.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05245; ABE05245; RBE_1164.
    GeneIDi3995942.
    KEGGirbe:RBE_1164.
    PATRICi17883927. VBIRicBel102610_1314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05245.1 .
    RefSeqi YP_538334.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RHB9.
    SMRi Q1RHB9. Positions 5-596.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05245 ; ABE05245 ; RBE_1164 .
    GeneIDi 3995942.
    KEGGi rbe:RBE_1164.
    PATRICi 17883927. VBIRicBel102610_1314.

    Phylogenomic databases

    eggNOGi COG1053.
    HOGENOMi HOG000160475.
    KOi K00239.
    OMAi SYRPVHV.
    OrthoDBi EOG6M3PC4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .
    BioCyci RBEL336407:GJCY-1199-MONOMER.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiSDHA_RICBR
    AccessioniPrimary (citable) accession number: Q1RHB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3