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Q1RHB9

- SDHA_RICBR

UniProt

Q1RHB9 - SDHA_RICBR

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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251FADBy similarity
Binding sitei246 – 2461SubstrateBy similarity
Binding sitei258 – 2581SubstrateBy similarity
Active sitei290 – 2901Proton acceptorBy similarity
Binding sitei357 – 3571SubstrateBy similarity
Binding sitei391 – 3911FADBy similarity
Binding sitei402 – 4021SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 236FADBy similarity
Nucleotide bindingi41 – 5616FADBy similarityAdd
BLAST
Nucleotide bindingi407 – 4082FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1199-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
Ordered Locus Names:RBE_1164
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Succinate dehydrogenase flavoprotein subunitPRO_0000280976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Tele-8alpha-FAD histidineBy similarity

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi336407.RBE_1164.

Structurei

3D structure databases

ProteinModelPortaliQ1RHB9.
SMRiQ1RHB9. Positions 5-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiSYRPVHV.
OrthoDBiEOG6M3PC4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RHB9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKSYNIIHH KFDVIVVGAG GAGLRAAFGM AEEGLNTACI SKLFPTRSHT
60 70 80 90 100
VAAQGGISAA LGNMGADDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI
110 120 130 140 150
LELEHYGVPF SRTEEGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI
160 170 180 190 200
LHTLYQQSLK HKVQFFIEYF AIDLLMENGE CRGVVAWNLD DGSLHCFRAH
210 220 230 240 250
NVVLATGGYG RAYFSATSAH TCTGDGGGMA IRAGLPLQDM EFVQFHPTGI
260 270 280 290 300
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE
310 320 330 340 350
IREGRGVGEH KDHVFLHLNH LSPEIVHSRL PGISETAKIF AGVDVTKEPI
360 370 380 390 400
PVLPTVHYNM GGIPTNYHGQ VIIKDGKNHN SVVKGLMSIG EAACVSVHGA
410 420 430 440 450
NRLGSNSLLD LVVFGRSAAL KAAELIKPAS PHKPVSEEAL EKIISRFDKI
460 470 480 490 500
RHSSGNISVA DLRLKMQRTM QSHASVFRTQ EVLDEGAEMI SEIRSGYKDI
510 520 530 540 550
KVNDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR GAHAREDYPD
560 570 580 590
RNDKEWMQHT LSGVDEAGKV VLDYKPVTLT TLSDEVKAIP PAKRVY
Length:596
Mass (Da):65,106
Last modified:May 16, 2006 - v1
Checksum:iF3A2C76895400AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05245.1.
RefSeqiWP_011477823.1. NC_007940.1.
YP_538334.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05245; ABE05245; RBE_1164.
GeneIDi3995942.
KEGGirbe:RBE_1164.
PATRICi17883927. VBIRicBel102610_1314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05245.1 .
RefSeqi WP_011477823.1. NC_007940.1.
YP_538334.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RHB9.
SMRi Q1RHB9. Positions 5-596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05245 ; ABE05245 ; RBE_1164 .
GeneIDi 3995942.
KEGGi rbe:RBE_1164.
PATRICi 17883927. VBIRicBel102610_1314.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
KOi K00239.
OMAi SYRPVHV.
OrthoDBi EOG6M3PC4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .
BioCyci RBEL336407:GJCY-1199-MONOMER.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiSDHA_RICBR
AccessioniPrimary (citable) accession number: Q1RHB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3