Q1RHA4 (ERA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Era

Gene names

Name:	era
Ordered Locus Names:	RBE_1179

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity. HAMAP-Rule MF_00367
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00367.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. Contains 1 G (guanine nucleotide-binding) domain. Contains 1 KH type-2 domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding RNA-binding rRNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC ribosomal small subunit biogenesis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: HAMAP SSU rRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	GTPase Era HAMAP-Rule MF_00367		PRO_0000277964
Regions
	Domain	20 – 125	106	G
	Domain	204 – 281	78	KH type-2
	Nucleotide binding	15 – 22	8	GTP Potential
	Nucleotide binding	62 – 66	5	GTP Potential
	Nucleotide binding	124 – 127	4	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RHA4 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 8301D70218D9859A	FASTA	295	33,700
	10 20 30 40 50 60 MTKQIQKTVS VCIIGRPNSG KSTLLNRIIG EKLSIVTPKV QTTRSIITGI ITLNDTQIIL 70 80 90 100 110 120 YDTPGIFEPK GTLEKAMVRC AWSSLHSADI VMLIIDSLKP LDSITHDILN KLRSLNVVPV 130 140 150 160 170 180 FLLNKIDVES KYIDDTKAFL AENYSDSLLF PISAISGENV DKLLEYITSK AKIAPWLYEE 190 200 210 220 230 240 DDITDLPMRF IAAEITREQL FLGLQQELPY KLTVQTEKWE ELKDKSVKIN QIIVVSRESY 250 260 270 280 290 KTIILGKNGS KIKELGAKSR MQMQQFFGFP VHLFLFVKVQ ELWEDNSDYY EYMKI

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05260.1.
RefSeq	YP_538349.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RHA4.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_1179.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE05260; ABE05260; RBE_1179.
GeneID	3996351.
KEGG	rbe:RBE_1179.
PATRIC	17883959. VBIRicBel102610_1330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1159.
HOGENOM	HOG000245597.
KO	K03595.
OMA	ITREQLF.
ProtClustDB	PRK00089.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-1214-MONOMER.
Family and domain databases
Gene3D	3.30.300.20. 1 hit.
HAMAP	MF_00367. GTPase_Era.
InterPro	IPR005662. GTP-bd_Era. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR004044. KH_dom_type_2. IPR009019. KH_prok-type. IPR005225. Small_GTP-bd_dom. [Graphical view]
Pfam	PF07650. KH_2. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
SUPFAM	SSF54814. KH_prok. 1 hit.
TIGRFAMs	TIGR00436. era. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERA_RICBR

Accession

Primary (citable) accession number: Q1RHA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program