ID   LEP_RICBR               Reviewed;         291 AA.
AC   Q1RHA1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Signal peptidase I;
DE            Short=SPase I;
DE            EC=3.4.21.89;
DE   AltName: Full=Leader peptidase I;
GN   Name=lepB; OrderedLocusNames=RBE_1182;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II
CC       membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the peptidase S26 family.
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DR   EMBL; CP000087; ABE05263.1; -; Genomic_DNA.
DR   RefSeq; YP_538352.1; -.
DR   MEROPS; S26.001; -.
DR   GeneID; 3996354; -.
DR   GenomeReviews; CP000087_GR; RBE_1182.
DR   KEGG; rbe:RBE_1182; -.
DR   HOGENOM; Q1RHA1; -.
DR   OMA; Q1RHA1; KPWIESV.
DR   BioCyc; RBEL336407:RBE_1182-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR   InterPro; IPR019759; Peptidase_S24_S26_cons-reg.
DR   InterPro; IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
DR   Gene3D; G3DSA:2.10.109.10; Pept_S24_S26_C; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR   PROSITE; PS00760; SPASE_I_2; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Hydrolase;
KW   Membrane; Transmembrane.
FT   CHAIN         1    291       Signal peptidase I.
FT                                /FTId=PRO_0000316273.
FT   TOPO_DOM      1     45       Cytoplasmic (Potential).
FT   TRANSMEM     46     66       Potential.
FT   TOPO_DOM     67    291       Periplasmic (Potential).
FT   ACT_SITE     70     70       By similarity.
FT   ACT_SITE    133    133       By similarity.
SQ   SEQUENCE   291 AA;  34121 MW;  0C743E8E8A94B434 CRC64;
     MTMKKLTSTT TTLWDNKLFI NNLKNFMQTN TESNNNKTTA QEWKSFILVV VIALMIRILI
     IESFVVPTGS MKATILENDR IFGTKYSYGY SNYSLSFFDF IHLFKGRIFA RTPERGDIII
     FRPPHEMNTR YIKRLIGLPG DKVQLIDDVI YINDEKIERV ESGIYVSEEG RKYLKFKETL
     PNGKTYFSYK LAPVLGIMFN DKYGNTDAFY VPEGEYFFLG DNRDQSNDSR IDLGFVPFEN
     FIAKAQFIWF STKITWWDSD IGVINLILKL KPWAESIRFN RIFRNLYSIE D
//