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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571S-adenosyl-L-methionine; via amide nitrogenUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
Alternative name(s):
M1G-methyltransferaseUniRule annotation
tRNA [GM37] methyltransferaseUniRule annotation
Gene namesi
Name:trmDUniRule annotation
Ordered Locus Names:RBE_1217
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282tRNA (guanine-N(1)-)-methyltransferasePRO_0000257463Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RH66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 1826S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0336.
HOGENOMiHOG000016242.
KOiK00554.
OMAiPWTEESI.
OrthoDBiEOG6J48RZ.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 2 hits.
HAMAPiMF_00605. TrmD.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR022437. RPE3.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamiPF01746. tRNA_m1G_MT. 2 hits.
[Graphical view]
SUPFAMiSSF75217. SSF75217. 2 hits.
TIGRFAMsiTIGR03775. RPE3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RH66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLHATILT VFPEMFPGTL GHSLAGQALQ KNIWSYDVIN IRDFGLTKHK
60 70 80 90 100
NVDDEAYGGG DGLIMRPDVL GNAIDHALSL NPRAKIYYPS PRGKVFTQGF
110 120 130 140 150
AKEILRDIQL NSESFRQDEF KEEPAEHIII REQRRMPQNS LVSSLLNDAV
160 170 180 190 200
NMIFLCGRYE GIDERVIEEY NITEISVGDY ILSGGEIPTL TILDCLIRLL
210 220 230 240 250
PGVLMNQNTL ASESFEKDGE FEGGLECGLY TRPEVWYNRK VPSVLLSGNH
260 270 280
KLINEWKKEQ SLMITKLRRP ELLKDLRDKE RS
Length:282
Mass (Da):32,110
Last modified:May 16, 2006 - v1
Checksum:iBDC34A9D0E207F81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05298.1.
RefSeqiWP_011477874.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05298; ABE05298; RBE_1217.
KEGGirbe:RBE_1217.
PATRICi17884050. VBIRicBel102610_1374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05298.1.
RefSeqiWP_011477874.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RH66.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE05298; ABE05298; RBE_1217.
KEGGirbe:RBE_1217.
PATRICi17884050. VBIRicBel102610_1374.

Phylogenomic databases

eggNOGiCOG0336.
HOGENOMiHOG000016242.
KOiK00554.
OMAiPWTEESI.
OrthoDBiEOG6J48RZ.

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1254-MONOMER.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 2 hits.
HAMAPiMF_00605. TrmD.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR022437. RPE3.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamiPF01746. tRNA_m1G_MT. 2 hits.
[Graphical view]
SUPFAMiSSF75217. SSF75217. 2 hits.
TIGRFAMsiTIGR03775. RPE3. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiTRMD_RICBR
AccessioniPrimary (citable) accession number: Q1RH66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.