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Q1RH66

- TRMD_RICBR

UniProt

Q1RH66 - TRMD_RICBR

Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571S-adenosyl-L-methionine; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
    Alternative name(s):
    M1G-methyltransferaseUniRule annotation
    tRNA [GM37] methyltransferaseUniRule annotation
    Gene namesi
    Name:trmDUniRule annotation
    Ordered Locus Names:RBE_1217
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282tRNA (guanine-N(1)-)-methyltransferasePRO_0000257463Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_1217.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RH66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni177 – 1826S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RNA methyltransferase TrmD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0336.
    HOGENOMiHOG000016242.
    KOiK00554.
    OMAiGESQKTP.
    OrthoDBiEOG6J48RZ.

    Family and domain databases

    Gene3Di1.10.1270.20. 1 hit.
    3.40.1280.10. 2 hits.
    HAMAPiMF_00605. TrmD.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR022437. RPE3.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PfamiPF01746. tRNA_m1G_MT. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMiSSF75217. SSF75217. 2 hits.
    TIGRFAMsiTIGR03775. RPE3. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RH66-1 [UniParc]FASTAAdd to Basket

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    MSRLHATILT VFPEMFPGTL GHSLAGQALQ KNIWSYDVIN IRDFGLTKHK    50
    NVDDEAYGGG DGLIMRPDVL GNAIDHALSL NPRAKIYYPS PRGKVFTQGF 100
    AKEILRDIQL NSESFRQDEF KEEPAEHIII REQRRMPQNS LVSSLLNDAV 150
    NMIFLCGRYE GIDERVIEEY NITEISVGDY ILSGGEIPTL TILDCLIRLL 200
    PGVLMNQNTL ASESFEKDGE FEGGLECGLY TRPEVWYNRK VPSVLLSGNH 250
    KLINEWKKEQ SLMITKLRRP ELLKDLRDKE RS 282
    Length:282
    Mass (Da):32,110
    Last modified:May 16, 2006 - v1
    Checksum:iBDC34A9D0E207F81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05298.1.
    RefSeqiWP_011477874.1. NC_007940.1.
    YP_538387.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05298; ABE05298; RBE_1217.
    GeneIDi3995685.
    KEGGirbe:RBE_1217.
    PATRICi17884050. VBIRicBel102610_1374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05298.1 .
    RefSeqi WP_011477874.1. NC_007940.1.
    YP_538387.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RH66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05298 ; ABE05298 ; RBE_1217 .
    GeneIDi 3995685.
    KEGGi rbe:RBE_1217.
    PATRICi 17884050. VBIRicBel102610_1374.

    Phylogenomic databases

    eggNOGi COG0336.
    HOGENOMi HOG000016242.
    KOi K00554.
    OMAi GESQKTP.
    OrthoDBi EOG6J48RZ.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-1254-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1270.20. 1 hit.
    3.40.1280.10. 2 hits.
    HAMAPi MF_00605. TrmD.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR022437. RPE3.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    Pfami PF01746. tRNA_m1G_MT. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMi SSF75217. SSF75217. 2 hits.
    TIGRFAMsi TIGR03775. RPE3. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiTRMD_RICBR
    AccessioniPrimary (citable) accession number: Q1RH66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3