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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRBEL336407:G1G4P-1755-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
Alternative name(s):
M1G-methyltransferaseUniRule annotation
tRNA [GM37] methyltransferaseUniRule annotation
Gene namesi
Name:trmDUniRule annotation
Ordered Locus Names:RBE_1217
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002574631 – 282tRNA (guanine-N(1)-)-methyltransferaseAdd BLAST282

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RH66
SMRiQ1RH66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni177 – 182S-adenosyl-L-methionine bindingUniRule annotation6

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000016242
KOiK00554
OMAiHIIIREQ
OrthoDBiPOG091H01WE

Family and domain databases

Gene3Di1.10.1270.201 hit
3.40.1280.102 hits
HAMAPiMF_00605 TrmD, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR022437 RPE3
IPR002649 tRNA_m1G_MeTrfase_bac
IPR023148 tRNA_m1G_MeTrfase_C
IPR029026 tRNA_m1G_MTases_N
IPR016009 tRNA_MeTrfase_TRMD/TRM10
PANTHERiPTHR32125:SF1 PTHR32125:SF1, 2 hits
PfamiView protein in Pfam
PF01746 tRNA_m1G_MT, 2 hits
PIRSFiPIRSF000386 tRNA_mtase, 1 hit
SUPFAMiSSF75217 SSF75217, 2 hits
TIGRFAMsiTIGR03775 RPE3, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RH66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLHATILT VFPEMFPGTL GHSLAGQALQ KNIWSYDVIN IRDFGLTKHK
60 70 80 90 100
NVDDEAYGGG DGLIMRPDVL GNAIDHALSL NPRAKIYYPS PRGKVFTQGF
110 120 130 140 150
AKEILRDIQL NSESFRQDEF KEEPAEHIII REQRRMPQNS LVSSLLNDAV
160 170 180 190 200
NMIFLCGRYE GIDERVIEEY NITEISVGDY ILSGGEIPTL TILDCLIRLL
210 220 230 240 250
PGVLMNQNTL ASESFEKDGE FEGGLECGLY TRPEVWYNRK VPSVLLSGNH
260 270 280
KLINEWKKEQ SLMITKLRRP ELLKDLRDKE RS
Length:282
Mass (Da):32,110
Last modified:May 16, 2006 - v1
Checksum:iBDC34A9D0E207F81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA Translation: ABE05298.1
RefSeqiWP_011477874.1, NC_007940.1

Genome annotation databases

EnsemblBacteriaiABE05298; ABE05298; RBE_1217
KEGGirbe:RBE_1217

Similar proteinsi

Entry informationi

Entry nameiTRMD_RICBR
AccessioniPrimary (citable) accession number: Q1RH66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome