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Q1RH58

- GPDA_RICBR

UniProt

Q1RH58 - GPDA_RICBR

Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei108 – 1081NAD; via amide nitrogenUniRule annotation
    Binding sitei108 – 1081SubstrateUniRule annotation
    Binding sitei140 – 1401NAD; via amide nitrogenUniRule annotation
    Active sitei191 – 1911Proton acceptorUniRule annotation
    Binding sitei258 – 2581NADUniRule annotation
    Binding sitei284 – 2841NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
    2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
    3. glycerol-3-phosphate catabolic process Source: InterPro
    4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    5. phospholipid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1262-MONOMER.
    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
    Alternative name(s):
    NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gpsAUniRule annotation
    Ordered Locus Names:RBE_1225
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000255361Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_1225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RH58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni258 – 2592Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0240.
    HOGENOMiHOG000246854.
    KOiK00057.
    OMAiVCHEGAD.
    OrthoDBiEOG6JDWF4.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RH58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRFKNIAVY GGGSFGTSLA AIAARVCENV TLFLRDEEIA KEITDKKTNT    50
    KYLGNIKLPS NLQATTNLDK IKDFELIIIA VPSYAFDEAI KLLKTHISND 100
    NILLIATKGF ARNPTELFSD RLKTLLSNNP IAFLSGPNLA KDLAKGLPAS 150
    ATIASLDIDL ANKISYNLSS EAFVASTIND VITLQVAGAL KNIFAIKSGI 200
    DMAKEQGENA KATLIVSALK EIAILSKALG GMKNNMDILL EAGVVGDLVL 250
    TCYSRSSRNT KFGYEFGISK DKQKFLQEYK ELVEGREAIK LVLELIERYD 300
    LDMPIVSSLG NVIR 314
    Length:314
    Mass (Da):34,243
    Last modified:May 16, 2006 - v1
    Checksum:iB6DCA89E4070CC51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05306.1.
    RefSeqiYP_538395.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05306; ABE05306; RBE_1225.
    GeneIDi3995493.
    KEGGirbe:RBE_1225.
    PATRICi17884068. VBIRicBel102610_1383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05306.1 .
    RefSeqi YP_538395.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RH58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05306 ; ABE05306 ; RBE_1225 .
    GeneIDi 3995493.
    KEGGi rbe:RBE_1225.
    PATRICi 17884068. VBIRicBel102610_1383.

    Phylogenomic databases

    eggNOGi COG0240.
    HOGENOMi HOG000246854.
    KOi K00057.
    OMAi VCHEGAD.
    OrthoDBi EOG6JDWF4.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .
    BioCyci RBEL336407:GJCY-1262-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiGPDA_RICBR
    AccessioniPrimary (citable) accession number: Q1RH58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3