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Q1RH58

- GPDA_RICBR

UniProt

Q1RH58 - GPDA_RICBR

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene
gpsA, RBE_1225
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081NAD; via amide nitrogen By similarity
Binding sitei108 – 1081Substrate By similarity
Binding sitei140 – 1401NAD; via amide nitrogen By similarity
Active sitei191 – 1911Proton acceptor By similarity
Binding sitei258 – 2581NAD By similarity
Binding sitei284 – 2841NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
  4. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
  3. glycerol-3-phosphate catabolic process Source: InterPro
  4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
  5. phospholipid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1262-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC:1.1.1.94)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene namesi
Name:gpsA
Ordered Locus Names:RBE_1225
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotationPRO_0000255361Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_1225.

Structurei

3D structure databases

ProteinModelPortaliQ1RH58.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni258 – 2592Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246854.
KOiK00057.
OMAiVCHEGAD.
OrthoDBiEOG6JDWF4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RH58-1 [UniParc]FASTAAdd to Basket

« Hide

MKRFKNIAVY GGGSFGTSLA AIAARVCENV TLFLRDEEIA KEITDKKTNT    50
KYLGNIKLPS NLQATTNLDK IKDFELIIIA VPSYAFDEAI KLLKTHISND 100
NILLIATKGF ARNPTELFSD RLKTLLSNNP IAFLSGPNLA KDLAKGLPAS 150
ATIASLDIDL ANKISYNLSS EAFVASTIND VITLQVAGAL KNIFAIKSGI 200
DMAKEQGENA KATLIVSALK EIAILSKALG GMKNNMDILL EAGVVGDLVL 250
TCYSRSSRNT KFGYEFGISK DKQKFLQEYK ELVEGREAIK LVLELIERYD 300
LDMPIVSSLG NVIR 314
Length:314
Mass (Da):34,243
Last modified:May 16, 2006 - v1
Checksum:iB6DCA89E4070CC51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05306.1.
RefSeqiYP_538395.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05306; ABE05306; RBE_1225.
GeneIDi3995493.
KEGGirbe:RBE_1225.
PATRICi17884068. VBIRicBel102610_1383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05306.1 .
RefSeqi YP_538395.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RH58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05306 ; ABE05306 ; RBE_1225 .
GeneIDi 3995493.
KEGGi rbe:RBE_1225.
PATRICi 17884068. VBIRicBel102610_1383.

Phylogenomic databases

eggNOGi COG0240.
HOGENOMi HOG000246854.
KOi K00057.
OMAi VCHEGAD.
OrthoDBi EOG6JDWF4.

Enzyme and pathway databases

UniPathwayi UPA00940 .
BioCyci RBEL336407:GJCY-1262-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiGPDA_RICBR
AccessioniPrimary (citable) accession number: Q1RH58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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